DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp49a1 and Cyp27b1

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_034139.2	Gene:	Cyp27b1 / 13115	MGIID:	1098274	Length:	507	Species:	Mus musculus

Alignment Length:	536	Identity:	154/536 - (28%)
Similarity:	235/536 - (43%)	Gaps:	78/536 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 LPAETTSS-----PAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKM 144
            ||.:..:|     ..:.:|..|::|||..|..:      |.|.....:|.|.::.......||.:
Mouse    17 LPLQLDASLGSRGSESVLRSLSDIPGPSTLSFL------AELFCKGGLSRLHELQVHGAARYGPI 75

  Fly   145 AKVGGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPK 209
              ..|..|....::|.|...:..:.::|...|.|.|..|...::...:|     ..||:...|.:
Mouse    76 --WSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRHQR-----ACGLLTADGEE 133

  Fly   210 WEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDEKDELPANFLH---ELYKWALESV 271
            |:..|..:..:||:||.|..|...|:::..:.:.|:...|.....||...|.   |.||:.|||:
Mouse   134 WQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESI 198

  Fly   272 GRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMPLW--RIYPTKAYRSFVKALDQFT 334
            |.|.|.:|||||..|...:.:..|.|:.:.|.:. .|.:.||.|  .:.| ..:....:..||..
Mouse   199 GAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVST-LLTMAMPNWLHHLIP-GPWARLCRDWDQMF 261

  Fly   335 AICMKNIGKTMDKADADEA-RGLSKSEADIS--------------IVERIVRKTGNRKLAAILAL 384
            |...:::    :..:.:.| |...|.|.|:.              .|:.||   ||       ..
Mouse   262 AFAQRHV----ELREGEAAMRNQGKPEEDMPSGHHLTHFLFREKVSVQSIV---GN-------VT 312

  Fly   385 DLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQK------VFPHREADINQNVLEQMPYLRA 443
            :|.|.||||.|...|.|:|:|:::||.|..|..|:..      ..||..|      |.|:|.|:|
Mouse   313 ELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHGTA------LSQLPLLKA 371

  Fly   444 CVKETLRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQS 508
            .:||.||:.|||..|.|....|..:..|.:|:.|.|...|...|.||..||:|..|.|.|||.:.
Mouse   372 VIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNSFNPARWLGEG 436

  Fly   509 TDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYR--VN 571
            ...          |||.|||||||:|.|:|||.||:||...|::|...::|....|....:  ..
Mouse   437 PTP----------HPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPEPGALPIKPMTR 491

  Fly   572 STYIPQSPLNFKLTLR 587
            :..:|:..:|.:...|
Mouse   492 TVLVPERSINLQFVDR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	145/486 (30%)
Cyp27b1	NP_034139.2	p450	41..504	CDD:278495	148/507 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3255
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2442
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.900