DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp49a1 and Cyp11b2

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_034121.4	Gene:	Cyp11b2 / 13072	MGIID:	88584	Length:	500	Species:	Mus musculus

Alignment Length:	491	Identity:	136/491 - (27%)
Similarity:	232/491 - (47%)	Gaps:	57/491 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 TTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKM 144
            |||:..|  .|..|..|:..||.           |.|  ..:|...:....:.:..|:|..:.::
Mouse    26 TTATLAP--KTLQPFEAIPQYSR-----------NKW--LKMIQILREQGQENLHLEMHQVFREL 75

  Fly   145 AKV-GGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSM-PSLRHYKGDLRRDFFGDVAGLIGVHG 207
            ..: ...:|...::.|...::...:.:.|..:|.|..: |.:.|      |:..|...|:..::|
Mouse    76 GPIFRHSVGKTQIVSVMLPEDAEKLHQVESMLPRRMHLEPWVAH------RELRGLRRGVFLLNG 134

  Fly   208 PKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRI--ELMRDEKDELPANFLHELYKWALES 270
            |:|...|..:...:|.|:..:|::|.::.:|.:|:..:  :::::.:..|..:....|:.:.:|:
Mouse   135 PEWRLNRLRLNRNVLSPKAVQKFVPMVDMVARDFLETLKEKVLQNARGSLTMDVQQSLFNYTIEA 199

  Fly   271 VGRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMP--LWRIYPTKAYRSFVKALDQF 333
            ........|||.|..:.|..:.:.|.|:::.|.:..:| |.:|  |.|...|:.::....|.|..
Mouse   200 SNFALFGERLGLLGHDLSPGSLKFIHALHSMFKSTSQL-LFLPKSLTRWTSTRVWKEHFDAWDVI 263

  Fly   334 TAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILA--LDLFLVGVDTTSV 396
            :....:.|.|.     ..|.| |..|:....||..::.: |:..|.||.|  ::|....||||::
Mouse   264 SEYANRCIWKV-----HQELR-LGSSQTYSGIVAELISQ-GSLPLDAIKANSMELTAGSVDTTAI 321

  Fly   397 AASSTIYQLAKNPDKQKKLFDELQKVFPHREADI---NQNVLEQMPYLRACVKETLRMRPVVIAN 458
            ....|:::||:|||.||.|..|....    ||.|   .|..:..:|.|||.:|||||:.||....
Mouse   322 PLVMTLFELARNPDVQKALRQESLAA----EASIAANPQKAMSDLPLLRAALKETLRLYPVGGFL 382

  Fly   459 GRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQKIHP 523
            .|.|.||.|:..||||.||.|:.....:..:||.||.|:|::|:|||::.             ..
Mouse   383 ERILSSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERK-------------RS 434

  Fly   524 FVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKV 559
            |..|.||||.|.|:|||.||:|:..||..|.:.::|
Mouse   435 FQHLAFGFGVRQCLGRRLAEVEMMLLLHHILKTFQV 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	127/467 (27%)
Cyp11b2	NP_034121.4	p450	42..496	CDD:365848	129/473 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920