DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp49a1 and Cyp11a1

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	NP_062753.3	Gene:	Cyp11a1 / 13070	MGIID:	88582	Length:	526	Species:	Mus musculus

Alignment Length:	553	Identity:	141/553 - (25%)
Similarity:	235/553 - (42%)	Gaps:	97/553 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QQPVTSVATTRTTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSW----RFAPLIGTYKISD 129
            |.||.|......|       :||||    |.::|:|.|.     .|.|    .|....||.||
Mouse    25 QGPVLSTGKGAGT-------STSSP----RSFNEIPSPG-----DNGWLNLYHFWRESGTQKI-- 71

  Fly   130 LDKVMNELHVNYGKM---AKVGGL----IGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHY 187
                      :|.:|   .|.|.:    :|..:.:::.|..:...:|..|...|.|..:|....|
Mouse    72 ----------HYHQMQSFQKYGPIYREKLGTLESVYIVDPKDASILFSCEGPNPERFLVPPWVAY 126

  Fly   188 KGDLRRDFFGDVAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDEK 252
                 ..::....|::......|:..|..:...::.|...|.::|.|..:|.:|:.  .|.|..|
Mouse   127 -----HQYYQRPIGVLFKSSDAWKKDRIVLNQEVMAPGAIKNFVPLLEGVAQDFIK--VLHRRIK 184

  Fly   253 DELPANF----LHELYKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAI-NTFFWAVPELELRM 312
            .:...||    ..:|::::.||:..|....|:|.|......|||:.|.|: ..|..:||.|.|..
Mouse   185 QQNSGNFSGVISDDLFRFSFESISSVIFGERMGMLEEIVDPEAQRFINAVYQMFHTSVPMLNLPP 249

  Fly   313 PLWRIYPTKAYRS--------FVKALDQFTAICMKNIGKTMDKADADEARGLSKSEADISIVERI 369
            ..:|:..||.::.        |.|| |::|.....::   ..|.|..:..|:            :
Mouse   250 DFFRLLRTKTWKDHAAAWDVIFNKA-DEYTQNFYWDL---RQKRDFSQYPGV------------L 298

  Fly   370 VRKTGNRKL------AAILALDLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREA 428
            ....|..||      |.|  .::...||||||:.....:|::|.|...|:.|..|:.......:.
Mouse   299 YSLLGGNKLPFKNIQANI--TEMLAGGVDTTSMTLQWNLYEMAHNLKVQEMLRAEVLAARRQAQG 361

  Fly   429 DINQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYF 493
            |: ..:::.:|.|:|.:|||||:.|:.:...|...:|.|:..|.:|..|.|......:..||.:|
Mouse   362 DM-AKMVQLVPLLKASIKETLRLHPISVTLQRYTVNDLVLRNYKIPAKTLVQVASFAMGRDPGFF 425

  Fly   494 PEPKRFLPERWLKQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYK 558
            |.|.:|.|.|||::|          |....|..|.||:|.|.|:|||.||:|:..||..:...::
Mouse   426 PNPNKFDPTRWLEKS----------QNTTHFRYLGFGWGVRQCLGRRIAELEMTILLINLLENFR 480

  Fly   559 VS-YNSGEFVYRVNSTYIPQSPL--NFKLTLRD 588
            :. .|..:...:.:...:|::|:  ||:...:|
Mouse   481 IEVQNLRDVGTKFSLILMPENPILFNFQPLKQD 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	125/491 (25%)
Cyp11a1	NP_062753.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49		8/29 (28%)
Cyp11a1	NP_062753.3	p450	49..507	CDD:278495	127/510 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2442
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.900