Protein Alignment Cyp49a1 and Cyp27b1

DIOPT Version :9

• Sequence 1: NP_001246256.1
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_446215.1
• Gene: Cyp27b1 / 114700
• RGDID: 69192
• Length: 501
• Species: Rattus norvegicus
• Alignment Length: 525
• Identity: 156/525 - (29%)
• Similarity: 235/525 - (44%)
• Gaps: 62/525 - (11%)

  Fly    85 LPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKMAKVGG 149
            ||::..|.  :.:|..|::|||.....:      |.|.....:|.|.::.......||.:  ..|
  Rat    17 LPSQLGSD--SVLRSLSDIPGPSTPSFL------AELFCKGGLSRLHELQVHGAARYGPI--WSG 71

  Fly   150 LIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFR 214
            ..|....::|.|...:..:.::|...|.|.|..|...::...:|     ..||:...|.:|:..|
  Rat    72 SFGTLRTVYVADPALVEQLLRQESHCPERCSFSSWSEHRRRHQR-----ACGLLTADGEEWQRLR 131

  Fly   215 QEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDEKDELPANFLH---ELYKWALESVGRVSL 276
            ..:..:||:||.|..|...|:.:.|:.:.|:...|.....||...|.   |.||:.||.:|.|.|
  Rat   132 SLLAPLLLRPQAAAGYAGTLDSVVSDLVRRLRRQRGRGSGLPDLVLDVAGEFYKFGLEGIGAVLL 196

  Fly   277 DTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMPLW--RIYPTKAYRSFVKALDQFTAICMK 339
            .:|||||..|...:.:..|||:.:.|.:. .|.:.||.|  |:.| ..:....:..||..|...|
  Rat   197 GSRLGCLEAEVPPDTETFIEAVGSVFVST-LLTMAMPSWLHRLIP-GPWARLCRDWDQMFAFAQK 259

  Fly   340 NIGKTMDKADADEARGLSKSEADISI--------------VERIVRKTGNRKLAAILALDLFLVG 390
            ::.:...:|   ..|...|.|.|:..              |:.||   ||       ..:|.|.|
  Rat   260 HVEQREGEA---AVRNQGKPEEDLPTGHHLTHFLFREKVSVQSIV---GN-------VTELLLAG 311

  Fly   391 VDTTSVAASSTIYQLAKNPDKQKKLFDELQ-KVFPHREADINQNVLEQMPYLRACVKETLRMRPV 454
            |||.|...|..:|:|:::|:.|..|..|:. .|.|...|.:....|.|:|.|:|.:||.||:.||
  Rat   312 VDTVSNTLSWALYELSRHPEVQSALHSEITGAVNPGSYAHLQATALSQLPLLKAVIKEVLRLYPV 376

  Fly   455 VIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQ 519
            |..|.|....|..:..|.:|:.|.|...|...|.|||.|.||..|.|.|||.:..    .|
  Rat   377 VPGNSRVPDRDICVGNYVIPQDTLVSLCHYATSRDPAQFREPNSFNPARWLGEGP----AP---- 433

  Fly   520 KIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYR--VNSTYIPQSPLNF 582
              |||.|||||||:|.|:|||.||:||...||:|...::|....|....:  ..:..:|:..::.
  Rat   434 --HPFASLPFGFGKRSCIGRRLAELELQMALAQILTHFEVLPEPGALPVKPMTRTVLVPERSIHL 496

  Fly   583 KLTLR 587
            :...|
  Rat   497 QFVDR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	148/480 (31%)
Cyp27b1	NP_446215.1	CYP27B1	61..496	CDD:410741	143/466 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.870