Protein Alignment Cyp49a1 and Cyp11b1

DIOPT Version :9

• Sequence 1: NP_001246256.1
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Sequence 2: NP_001028401.2
• Gene: Cyp11b1 / 110115
• MGIID: 88583
• Length: 501
• Species: Mus musculus
• Alignment Length: 526
• Identity: 141/526 - (26%)
• Similarity: 241/526 - (45%)
• Gaps: 73/526 - (13%)

  Fly    80 TTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKM 144
            |||:..|  .|..|..|:..||.           |.|  ..:|...:....:.:..|:|..:.::
Mouse    28 TTATLAP--KTLQPFEAIPQYSR-----------NKW--LKMIQILREQGQENLHLEMHQVFREL 77

  Fly   145 AKV-GGLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPS-LRHYKGDLRRDFFGDVAGLIGVHG 207
            ..: ...:|...::||...:::..:::.|...|.|..:.| :.|      |:..|...|:..::|
Mouse    78 GPIFRHSVGKTQIVFVTLPEDVEKLYQVESTHPCRMPLESWIVH------RELRGLGRGVFLLNG 136

  Fly   208 PKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRI--ELMRDEKDELPANFLHELYKWALES 270
            |:|...|.::...:|.|:..:|::|.::.||.:|:..:  :::.........:|...::.:.:|:
Mouse   137 PEWYFNRLQLNPNVLSPKAVQKFVPLVDGIARDFVDNLKKKMLESVHGSFSMDFQSSVFNYTIEA 201

  Fly   271 VGRVSLDTRLGCLSPEGSEEAQQIIEAINTFFWAVPELELRMP--LWRIYPTKAYRSFVKALD-- 331
            ...|....|||.:..:.|.::.:.:..:::.|....:| |.:|  |.|...|:.::..:::.|
Mouse   202 SHFVLFGERLGLIGRDLSPDSLKFLHTLHSMFKTTTQL-LYLPRSLTRWTSTRVWKENLESWDFI 265

  Fly   332 -QFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTGNRKLAAILA--LDLFLVGVDT 393
             ::...|:||:.:     :..|.|..|.|.....:.||.:      .:.||.|  ::|.....||
Mouse   266 SEYVTKCIKNVYR-----ELAEGRPQSWSVTAELVAERTL------SMDAIQANSMELIAGSTDT 319

  Fly   394 TSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADI---NQNVLEQMPYLRACVKETLRMRPVV 455
            ||.....|.::||:|||.|:.|..|....    ||.|   .|..:..:|.|||.:|||||:.||.
Mouse   320 TSTPLVMTFFELARNPDVQQALRQESLAA----EASIAANPQKAMSDLPLLRAALKETLRLYPVG 380

  Fly   456 IANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPHANQK 520
            ....|.|.||.|:..||||.||.:......:..:||.||.|:|::|:|||::.
Mouse   381 TFLERILSSDLVLQNYHVPAGTVLNVNLYSMGRNPAVFPRPERYMPQRWLERK------------ 433

  Fly   521 IHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFV---YRVNSTYIP-QSPLN 581
             ..|..|.||||.|.|:|||.||.|:..||..:.:.:.|.....|.|   ||.  ..:| .|||
Mouse   434 -RSFKHLAFGFGVRQCLGRRLAEAEMMLLLHHVLKSFHVETQEKEDVRMAYRF--VLMPSSSPL- 494

  Fly   582 FKLTLR 587
              ||.|
Mouse   495 --LTFR 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	121/474 (26%)
Cyp11b1	NP_001028401.2	p450	44..497	CDD:278495	132/505 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820