DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp49a1 and Cyp27a1

DIOPT Version :9

Sequence 1:NP_001246256.1 Gene:Cyp49a1 / 36105 FlyBaseID:FBgn0033524 Length:589 Species:Drosophila melanogaster
Sequence 2:NP_077226.2 Gene:Cyp27a1 / 104086 MGIID:88594 Length:533 Species:Mus musculus


Alignment Length:522 Identity:153/522 - (29%)
Similarity:244/522 - (46%) Gaps:86/522 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 SSLPA-----ETTSSPAAA-----VRPYSEVPGPYPLPLIGNSWRFAPLIGTY--KISDLDKVMN 135
            :::||     |:|..|...     :|..:|:||...|..:     |...:..|  .:.|| :|:|
Mouse    32 ATIPAALQAQESTEGPGTGQDRPRLRSPAELPGTGTLQFL-----FQLFLQGYVLHLPDL-QVLN 90

  Fly   136 ELHVNYGKMAKVG-GLIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDV 199
            :  ..||.|.... |...:.:|.   ....:..:.::|...|.|..|...:.:     ||..|..
Mouse    91 K--TKYGPMWTTSFGTYTNVNLA---SAPLLEQVMRQEGKYPIRDHMDQWKDH-----RDHKGLT 145

  Fly   200 AGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDEK---DELPANFLH 261
            .|:....|.:|...||.::..||:|..|..|...||::.|:|:.|::.:|.|.   |::| :..|
Mouse   146 YGIFIAQGEQWYHLRQALKQRLLKPDEAALYTDALNEVISDFITRLDQVRAESESGDQVP-DMAH 209

  Fly   262 ELYKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAINTFF-----------WAVPELELRMPLW 315
            .||..|||::..:..:.|:|||.|...|:....|.::...|           |..|.|    |.|
Mouse   210 LLYHLALEAITYILFEKRIGCLKPSIPEDTAAFIRSVAIMFQNSVYITFLPKWTRPLL----PFW 270

  Fly   316 RIYPTKAYRSFVKALDQFTAICMKNIGKTMDKADADEARGLSKSEADISIVERIVRKTG------ 374
            :.|        :...|...:...|.|.:.:.:..|.    |.::..|      .||.:|      
Mouse   271 KRY--------LNGWDNIFSFGKKLIDEKVQELKAQ----LQETGPD------GVRVSGYLHFLL 317

  Fly   375 -NRKLAAILAL----DLFLVGVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNV 434
             |..|:....:    :|.|.||||||...:..:|.|:|:|:.|:.|..|:..|.|..:...::: 
Mouse   318 TNELLSTQETIGTFPELLLAGVDTTSNTLTWALYHLSKSPEIQEALHKEVTGVVPFGKVPQHKD- 381

  Fly   435 LEQMPYLRACVKETLRMRPVVIANGRSL-QSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKR 498
            ...||.|:|.:|||||:.|||..|.|.: :.:..|||:..||.|..:..|.|||.||:.||||..
Mouse   382 FAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPKNTQFVLCHYVVSRDPSVFPEPNS 446

  Fly   499 FLPERWL-KQSTDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYN 562
            |.|.||| |:..|..|.      :|||.|:|||:|.|.|:|||.||:|:..:|:::.:||:::..
Mouse   447 FQPHRWLRKKEADNPGI------LHPFGSVPFGYGVRSCLGRRIAELEMQLMLSRLVQKYEIALA 505

  Fly   563 SG 564
            .|
Mouse   506 PG 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp49a1NP_001246256.1 p450 104..565 CDD:299894 146/491 (30%)
Cyp27a1NP_077226.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 34..60 6/25 (24%)
p450 82..527 CDD:278495 141/467 (30%)
Sterol-binding. /evidence=ECO:0000255 386..400 8/13 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 190 1.000 Domainoid score I3255
eggNOG 1 0.900 - - E2759_KOG0159
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H36040
Inparanoid 1 1.050 196 1.000 Inparanoid score I3800
Isobase 1 0.950 - 0 Normalized mean entropy S4770
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8705
orthoMCL 1 0.900 - - OOG6_100895
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X156
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.710

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