DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp49a1 and cyp24a1

DIOPT Version :9

Sequence 1:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster
Sequence 2:	XP_012808417.2	Gene:	cyp24a1 / 100497429	XenbaseID:	XB-GENE-479201	Length:	508	Species:	Xenopus tropicalis

Alignment Length:	529	Identity:	152/529 - (28%)
Similarity:	240/529 - (45%)	Gaps:	80/529 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 TRTTASSLPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDK---VMNELHV 139
            |.|....|..|...:|::.....:.:|||..||::|:      |:...:...|.:   .:...|.
Frog    27 TATAVCDLKEEELPAPSSCPHSLAALPGPTKLPILGS------LLDILRKGGLKRQHEALASYHK 85

  Fly   140 NYGKM--AKVGGL----IGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGD 198
            .:||:  .|:|..    ||.|.||        ..::::|...|.|..:...:.|     ||:..:
Frog    86 QFGKIFRMKLGSFDSVHIGAPCLL--------EALYREESNYPKRLEIKPWKAY-----RDYRDE 137

  Fly   199 VAGLIGVHGPKWEAFRQEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDEKDELPANFLHEL 263
            ..||:.:.|..|:..|...|..|::|....|....:|::..:||.||:.:.|| |....:...||
Frog   138 AYGLLILEGKDWQRVRSAFQQKLMKPTEVGKLDTKINEVLVDFMKRIDSVCDE-DGTIEDLYCEL 201

  Fly   264 YKWALESVGRVSLDTRLGCLSPEGSEEAQQIIEAI----NTF-FWAVPELELRMPLWRIYPTKAY 323
            .||:|||:..|..:.|.|.|.|...||||..|.||    :|| ...|..:||...|    .||.:
Frog   202 NKWSLESICLVLYEKRFGFLQPNLGEEAQNFITAIKMMMSTFGLMMVTPVELHKSL----NTKIW 262

  Fly   324 RSFVKALDQF--TAICM--KNIGKTMDKADAD------EARGLSKSEADISIVERIVRKTGNRKL 378
            :....|.|..  ||.|.  :.:.|...|...|      ....|||.|...:|.|
Frog   263 KDHTHAWDSIFKTAKCHIDRRLTKLSSKGSEDFLCTIYNDSKLSKKEMYATITE----------- 316

  Fly   379 AAILALDLFLVG-VDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLR 442
                    .|:| |:||:.:....|:.:::||..||||.:|::.|....:.....:: ..||||:
Frog   317 --------MLIGAVETTANSLLWAIFNISRNPHIQKKLLEEIESVLLPDQVPTADDI-RNMPYLK 372

  Fly   443 ACVKETLRMRPVVIANGRSLQSDAVINGYHVPKGTHVIFPHLVVSNDPAYFPEPKRFLPERWLKQ 507
            ||:||::|:.|.:....|:|..:.|:..|.:||||.:.....|:.::...|....:|.|||||:|
Frog   373 ACLKESMRITPSIPFTTRTLDKETVLGDYVLPKGTVLTINSHVLGSNQECFDNWNQFRPERWLQQ 437

  Fly   508 STDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNSGEFVYRVN- 571
                      ...|:||..:|||.|:|||:|||.||::|...|..:.|||::.....:.|..::
Frog   438 ----------KNTINPFAHVPFGIGKRMCIGRRLAELQLQLTLCWLIRKYEIVATDNDPVETLHL 492

  Fly   572 STYIPQSPL 580
            .|.:|...|
Frog   493 GTLMPSREL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	143/485 (29%)
cyp24a1	XP_012808417.2	CYP24A1	84..502	CDD:410738	139/466 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I3126
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	208	1.000	Inparanoid score	I3591
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm9361
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2442
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.000