DRSC/TRiP Functional Genomics Resources

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Protein Alignment Galphao and GNA14

DIOPT Version :10

Sequence 1:NP_523684.2 Gene:Galphao / 36104 FlyBaseID:FBgn0001122 Length:354 Species:Drosophila melanogaster
Sequence 2:NP_004288.1 Gene:GNA14 / 9630 HGNCID:4382 Length:355 Species:Homo sapiens


Alignment Length:348 Identity:181/348 - (52%)
Similarity:239/348 - (68%) Gaps:3/348 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 CAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAEDFK 67
            |..||||:.:...|..|||.|:.|...|.:::||||||.|||||||.:|||:|||.||::.||.|
Human     5 CCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDRK 69

  Fly    68 QYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPFSEELLAAMKRLW 132
            .:..:||.|...::.|::|||.||.|||...:.:.:|:::.:|  .:......|.|.:.|:|:||
Human    70 GFTKLVYQNIFTAMQAMIRAMDTLRIQYVCEQNKENAQIIREV--EVDKVSMLSREQVEAIKQLW 132

  Fly   133 QDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNLNF 197
            ||.|:|||:.|..||||:|||||:|.|:||:....:.||:||:||.||.||||:|..|..:|:.|
Human   133 QDPGIQECYDRRREYQLSDSAKYYLTDIDRIATPSFVPTQQDVLRVRVPTTGIIEYPFDLENIIF 197

  Fly   198 KLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWFTD 262
            ::.|||||||||:|||||||.||:|||.||:|||||||.|.:..|||:||..||.:|....||.:
Human   198 RMVDVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFLN 262

  Fly   263 TSIILFLNKKDLFEEKIRKSPLTICFPEYTG-GQEYGEAAAYIQAQFEAKNKSTSKEIYCHMTCA 326
            :|:|||||||||.||||..|.|...|||||| .|:...|..:|...::.:|....|.||.|.|||
Human   263 SSVILFLNKKDLLEEKIMYSHLISYFPEYTGPKQDVRAARDFILKLYQDQNPDKEKVIYSHFTCA 327

  Fly   327 TDTNNIQFVFDAVTDVIIANNLR 349
            |||:||:|||.||.|.|:..|||
Human   328 TDTDNIRFVFAAVKDTILQLNLR 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GalphaoNP_523684.2 G-alpha 34..348 CDD:206639 166/314 (53%)
GNA14NP_004288.1 G-alpha 36..349 CDD:206639 166/314 (53%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 37..50 11/12 (92%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 174..182 5/7 (71%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 197..206 5/8 (63%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 266..273 6/6 (100%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 325..330 4/4 (100%)

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