DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphao and Gna15

DIOPT Version :9

Sequence 1:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_445994.2	Gene:	Gna15 / 89788	RGDID:	619751	Length:	374	Species:	Rattus norvegicus

Alignment Length:	363	Identity:	154/363 - (42%)
Similarity:	219/363 - (60%)	Gaps:	18/363 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GCAQ---SAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTA 63
            ||..   :.||:.||...:.|.:.|.|...|...::||||||.|||||||.:|||:|||.:|::.
  Rat     8 GCCPWCLTEEEKTAARIDQEINKILLEQKKQERGELKLLLLGPGESGKSTFIKQMRIIHGAGYSE 72

  Fly    64 EDFKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPFSEELLAAM 128
            ||.:.:|.:||.|...|:.|::.||..|.|.:|..:.:..|.:|  :.|..:....|.:....||
  Rat    73 EDRRAFRLLVYQNIFVSMQAMIEAMDRLQIPFSRPDSKQHASLV--MTQDPYKVSSFEKPYAVAM 135

  Fly   129 KRLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFK 193
            :.||:|||::.|:.|..|:.|.|||.|:|..|:|:...||.||.||:||:|:.||||.|..||.:
  Rat   136 QYLWRDAGIRACYERRREFHLLDSAVYYLSHLERIAEDDYIPTAQDVLRSRMPTTGINEYCFSVQ 200

  Fly   194 NLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNK 258
            ....::.|||||:|||||||||||:|.|:|:..::|||||.|.|:...|||:|||.||.:|....
  Rat   201 KTKLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENSQENRMKESLALFSTILELP 265

  Fly   259 WFTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAA--------AYIQAQFE-----A 310
            ||..||:||||||.|:.|:||..|.|...||.:.|.:...|||        |.:.|...     .
  Rat   266 WFKSTSVILFLNKTDILEDKIHTSHLASYFPSFQGPRRDAEAAKRFILDMYARVYASCAEPHDGG 330

  Fly   311 KNKSTSKEIYCHMTCATDTNNIQFVFDAVTDVIIANNL 348
            :..|.::.::.|.||||||::::.||..|.|.::|..|
  Rat   331 RKGSRARRLFAHFTCATDTHSVRSVFKDVRDSVLARYL 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	143/326 (44%)
Gna15	NP_445994.2	G-alpha	43..368	CDD:206639	143/326 (44%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	44..57		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	181..189		4/7 (57%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	273..280		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	344..349		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830