DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphao and Gnaq

DIOPT Version :9

Sequence 1:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_112298.2	Gene:	Gnaq / 81666	RGDID:	620770	Length:	359	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	178/353 - (50%)
Similarity:	233/353 - (66%)	Gaps:	9/353 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65
            |.|..|.|.:.|...:..|||.|:.|...|.:::||||||.|||||||.:|||:|||.||::.||
  Rat     7 MACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDED 71

  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTE---PFSEELLAA 127
            .:.:..:||.|...::.|::|||.||.|.|.....::.|::|.:|     |.|   .|....:.|
  Rat    72 KRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREV-----DVEKVSAFENPYVDA 131

  Fly   128 MKRLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSF 192
            :|.||.|.|:|||:.|..||||:||.||:|:||||:....|.||:||:||.||.||||:|..|..
  Rat   132 IKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPSYLPTQQDVLRVRVPTTGIIEYPFDL 196

  Fly   193 KNLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNN 257
            :::.|::.|||||||||:|||||||:||:|:|.||:|||||||.|.:..|||:||..||.:|...
  Rat   197 QSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITY 261

  Fly   258 KWFTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAA-AYIQAQFEAKNKSTSKEIYC 321
            .||.::|:|||||||||.||||..|.|...||||.|.|...:|| .:|...|...|..:.|.||.
  Rat   262 PWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYS 326

  Fly   322 HMTCATDTNNIQFVFDAVTDVIIANNLR 349
            |.||||||.||:|||.||.|.|:..||:
  Rat   327 HFTCATDTENIRFVFAAVKDTILQLNLK 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	165/317 (52%)
Gnaq	NP_112298.2	G-alpha	40..353	CDD:206639	165/317 (52%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	41..54		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	178..186		5/7 (71%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	201..210		5/8 (63%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	329..334		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830