Protein Alignment Galphao and Gna12

DIOPT Version :10

• Sequence 1: NP_523684.2
• Gene: Galphao / 36104
• FlyBaseID: FBgn0001122
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_112296.1
• Gene: Gna12 / 81663
• RGDID: 71018
• Length: 379
• Species: Rattus norvegicus
• Alignment Length: 352
• Identity: 154/352 - (43%)
• Similarity: 221/352 - (62%)
• Gaps: 6/352 - (1%)

  Fly     2 GCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAEDF 66
            |.|:.| ||.|..|||.|:..|..:.....:.:|:||||||||||||.:|||:|||...|..:..
  Rat    25 GAARDA-EREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKAL 88

  Fly    67 KQYRPVVYSNTIQSLVAILRAMPTLSI--QYSNNERESDAKMVFDVCQRMHDTEPFSEEL-LAAM 128
            .::|..::.|.::....::.|...|.|  |:|.||:.....|.|:....: ..||.:.:| :.|:
  Rat    89 LEFRDTIFDNILKGSRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGL-PVEPATFQLYVPAL 152

  Fly   129 KRLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFK 193
            ..||:|:|::|.|||.:|:||.:|.|||||:|||:|..:|.|::||||..|..|.||||..|..|
  Rat   153 SALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIK 217

  Fly   194 NLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNK 258
            .:.||:.|||||||:|:||..||:.:|:|:|.|:.|||||||.||..|||:.||:.:|::|.|||
  Rat   218 KIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNK 282

  Fly   259 WFTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGG-QEYGEAAAYIQAQFEAKNKSTSKEIYCH 322
            .|.:.||||||||.||..||::...:...||::.|. ....:...|:...|:.|.::..|.::.|
  Rat   283 LFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRGKPLFHH 347

  Fly   323 MTCATDTNNIQFVFDAVTDVIIANNLR 349
            .|.|.||.||:|||.||.|.|:..||:
  Rat   348 FTTAIDTENIRFVFHAVKDTILQENLK 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	141/317 (44%)
Gna12	NP_112296.1	G_alpha	40..377	CDD:214595	145/336 (43%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	57..70		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	198..206		4/7 (57%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	221..230		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	290..297		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	349..354		2/4 (50%)