DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphao and Gna12

DIOPT Version :9

Sequence 1:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_112296.1	Gene:	Gna12 / 81663	RGDID:	71018	Length:	379	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	154/352 - (43%)
Similarity:	221/352 - (62%)	Gaps:	6/352 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAEDF 66
            |.|:.| ||.|..|||.|:..|..:.....:.:|:||||||||||||.:|||:|||...|..:..
  Rat    25 GAARDA-EREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKAL 88

  Fly    67 KQYRPVVYSNTIQSLVAILRAMPTLSI--QYSNNERESDAKMVFDVCQRMHDTEPFSEEL-LAAM 128
            .::|..::.|.::....::.|...|.|  |:|.||:.....|.|:....: ..||.:.:| :.|:
  Rat    89 LEFRDTIFDNILKGSRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGL-PVEPATFQLYVPAL 152

  Fly   129 KRLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFK 193
            ..||:|:|::|.|||.:|:||.:|.|||||:|||:|..:|.|::||||..|..|.||||..|..|
  Rat   153 SALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIK 217

  Fly   194 NLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNK 258
            .:.||:.|||||||:|:||..||:.:|:|:|.|:.|||||||.||..|||:.||:.:|::|.|||
  Rat   218 KIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNK 282

  Fly   259 WFTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGG-QEYGEAAAYIQAQFEAKNKSTSKEIYCH 322
            .|.:.||||||||.||..||::...:...||::.|. ....:...|:...|:.|.::..|.::.|
  Rat   283 LFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRGKPLFHH 347

  Fly   323 MTCATDTNNIQFVFDAVTDVIIANNLR 349
            .|.|.||.||:|||.||.|.|:..||:
  Rat   348 FTTAIDTENIRFVFHAVKDTILQENLK 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	141/317 (44%)
Gna12	NP_112296.1	G_alpha	40..377	CDD:214595	145/336 (43%)
		G-alpha	56..373	CDD:206639	141/317 (44%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	57..70		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	198..206		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	221..230		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	290..297		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	349..354		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830