DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphao and gnai1

DIOPT Version :9

Sequence 1:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_957265.1	Gene:	gnai1 / 393946	ZFINID:	ZDB-GENE-040426-1310	Length:	354	Species:	Danio rerio

Alignment Length:	356	Identity:	246/356 - (69%)
Similarity:	290/356 - (81%)	Gaps:	4/356 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65
            |||..|.|::||..||::|:|||::||.:||:::||||||||||||||||||||||||:|::.|:
Zfish     1 MGCTLSTEDKAAVERSKMIDRNLRDDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEE 65

  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPF-SEELLAAMK 129
            .|||:.|||||||||::||:|||..|.|.:.:..|..||:.:|.:.....  |.| :.||...:|
Zfish    66 CKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDAARADDARQLFVLAGSAE--EGFMTAELAGVIK 128

  Fly   130 RLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKN 194
            |||:|.|||.|||||.||||||||.|:|:||||:....|.||:||:||||||||||||.||:||:
Zfish   129 RLWKDGGVQACFSRSREYQLNDSAAYYLNDLDRISQATYIPTQQDVLRTRVKTTGIVETHFTFKD 193

  Fly   195 LNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKW 259
            |:||:||||||||||||||||||.|||||||||:|:||.||.|||..|||.||:|||||||||||
Zfish   194 LHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKW 258

  Fly   260 FTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKNK-STSKEIYCHM 323
            |||||||||||||||||||||||.||||:|||.|...|.|||||||.|||..|| ..:||||.|.
Zfish   259 FTDTSIILFLNKKDLFEEKIRKSTLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHF 323

  Fly   324 TCATDTNNIQFVFDAVTDVIIANNLRGCGLY 354
            ||||||.|:||||||||||||.|||:.|||:
Zfish   324 TCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	224/315 (71%)
gnai1	NP_957265.1	G_alpha	14..352	CDD:214595	236/339 (70%)
gnai1	NP_957265.1	G-alpha	34..348	CDD:206639	224/315 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R506
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.760