DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphao and Galphas

DIOPT Version :9

Sequence 1:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster

Alignment Length:	382	Identity:	162/382 - (42%)
Similarity:	219/382 - (57%)	Gaps:	35/382 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGC----------AQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKI 55
            |||          ..|.:.::...||..|.|.|::|........:||||||||||||||||||:|
  Fly     1 MGCFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRI 65

  Fly    56 IHESGFTAEDFKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPF 120
            :|..||:..:.||....:..|...:::.|..||.||:...:..::|::.::  :..|....:..|
  Fly    66 LHVDGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRV--EYIQDYASSPDF 128

  Fly   121 S--EELLAAMKRLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTT 183
            :  .|.....:.||:|.||.:.:.|||||||.|.||||||.:..:...:|.|.||||||.||.|:
  Fly   129 NYPPEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTS 193

  Fly   184 GIVEVHFSFKNLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESL 248
            ||.|..|....:||.:|||||||.||:|||.||.|||||||..|.|.|:.||.||.|.||::|||
  Fly   194 GIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESL 258

  Fly   249 KLFDSICNNKWFTDTSIILFLNKKDLFEEKIR--KSPLTICFPEY--------TGG--QEYGEAA 301
            .||.||.||:|....||||||||:||..|||:  ||.|:..|.|:        ||.  .|..:..
  Fly   259 DLFKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDP 323

  Fly   302 AYIQAQFEAKNK----STSK---EIYC--HMTCATDTNNIQFVFDAVTDVIIANNLR 349
            ..|:|::..:::    ||:.   :.||  |.|||.||.||:.||:...|:|...:||
  Fly   324 EVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLR 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	150/336 (45%)
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	150/336 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455791
Domainoid	1	1.000	229	1.000	Domainoid score	I660
eggNOG	1	0.900	-	-		E1_KOG0082
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	233	1.000	Inparanoid score	I1124
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3584
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10218
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900