DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphao and Gna14

DIOPT Version :9

Sequence 1:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001013169.1	Gene:	Gna14 / 309242	RGDID:	1308122	Length:	355	Species:	Rattus norvegicus

Alignment Length:	348	Identity:	180/348 - (51%)
Similarity:	241/348 - (69%)	Gaps:	3/348 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAEDFK 67
            |..||||:.:...|..|||.|:.|...|.:::||||||.|||||||.:|||:|||.||::.||.|
  Rat     5 CCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDRK 69

  Fly    68 QYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPFSEELLAAMKRLW 132
            .:..:||.|...::.|::|||.||.|||:..:.:.:|:::.:|  .:......|.:.:||:|:||
  Rat    70 GFTKLVYQNIFTAMQAMIRAMDTLRIQYTCEQNKENAQIIREV--EVDKVSAISRDQVAAIKQLW 132

  Fly   133 QDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNLNF 197
            .|.|:|||:.|..||||:|||||:|.|:||:....:.||:||:||.||.||||:|..|..:|:.|
  Rat   133 LDPGIQECYDRRREYQLSDSAKYYLTDIDRIAMPSFVPTQQDVLRVRVPTTGIIEYPFDLENIIF 197

  Fly   198 KLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWFTD 262
            ::.|||||||||:|||||||.||:|||.||:|||||||.|.:..|||:||..||.:|....||.:
  Rat   198 RMVDVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFLN 262

  Fly   263 TSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAA-YIQAQFEAKNKSTSKEIYCHMTCA 326
            :|:|||||||||.||||..|.|...||||||.::..:||. :|...::.:|....|.||.|.|||
  Rat   263 SSVILFLNKKDLLEEKIMYSHLISYFPEYTGPKQDVKAARDFILKLYQDQNPDKEKVIYSHFTCA 327

  Fly   327 TDTNNIQFVFDAVTDVIIANNLR 349
            |||.||:|||.||.|.|:..|||
  Rat   328 TDTENIRFVFAAVKDTILQLNLR 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	165/314 (53%)
Gna14	NP_001013169.1	G_alpha	16..353	CDD:214595	175/337 (52%)
Gna14	NP_001013169.1	G-alpha	36..349	CDD:206639	165/314 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830