Protein Alignment Galphao and GNAQ

DIOPT Version :10

• Sequence 1: NP_523684.2
• Gene: Galphao / 36104
• FlyBaseID: FBgn0001122
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_002063.2
• Gene: GNAQ / 2776
• HGNCID: 4390
• Length: 359
• Species: Homo sapiens
• Alignment Length: 353
• Identity: 178/353 - (50%)
• Similarity: 233/353 - (66%)
• Gaps: 9/353 - (2%)

  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65
            |.|..|.|.:.|...:..|||.|:.|...|.:::||||||.|||||||.:|||:|||.||::.||
Human     7 MACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDED 71

  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTE---PFSEELLAA 127
            .:.:..:||.|...::.|::|||.||.|.|.....::.|::|.:|     |.|   .|....:.|
Human    72 KRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREV-----DVEKVSAFENPYVDA 131

  Fly   128 MKRLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSF 192
            :|.||.|.|:|||:.|..||||:||.||:|:||||:....|.||:||:||.||.||||:|..|..
Human   132 IKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVLRVRVPTTGIIEYPFDL 196

  Fly   193 KNLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNN 257
            :::.|::.|||||||||:|||||||:||:|:|.||:|||||||.|.:..|||:||..||.:|...
Human   197 QSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITY 261

  Fly   258 KWFTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAA-AYIQAQFEAKNKSTSKEIYC 321
            .||.::|:|||||||||.||||..|.|...||||.|.|...:|| .:|...|...|..:.|.||.
Human   262 PWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYS 326

  Fly   322 HMTCATDTNNIQFVFDAVTDVIIANNLR 349
            |.||||||.||:|||.||.|.|:..||:
Human   327 HFTCATDTENIRFVFAAVKDTILQLNLK 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	165/317 (52%)
GNAQ	NP_002063.2	G-alpha	40..353	CDD:206639	165/317 (52%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	41..54		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	178..186		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	201..210		5/8 (63%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	329..334		4/4 (100%)