Protein Alignment Galphao and GNAL

DIOPT Version :10

• Sequence 1: NP_523684.2
• Gene: Galphao / 36104
• FlyBaseID: FBgn0001122
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_892023.1
• Gene: GNAL / 2774
• HGNCID: 4388
• Length: 458
• Species: Homo sapiens
• Alignment Length: 374
• Identity: 166/374 - (44%)
• Similarity: 225/374 - (60%)
• Gaps: 32/374 - (8%)

  Fly     6 SAEERAAA--------AR--SRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESG 60
            |||||.||        ||  ||.|:|.|::......:..:||||||||||||||||||:|:|.:|
Human    82 SAEEREAAKEREAVKEARKVSRGIDRMLRDQKRDLQQTHRLLLLGAGESGKSTIVKQMRILHVNG 146

  Fly    61 FTAEDFKQYRPVVYSNTIQSLVAILRAMPTL--SIQYSNNERESDAKMVFDVCQRMHDTEPFSEE 123
            |..|:.||....:..|...::|.|:.||.|:  .:..:|.|.:..:..:..:.. :.|.| :|:|
Human   147 FNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKSIAP-ITDFE-YSQE 209

  Fly   124 LLAAMKRLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEV 188
            ....:|:||.|.||:.||.|||||||.|.|:|||:.:|.:...||.||:||:||.||.|:||.|.
Human   210 FFDHVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFET 274

  Fly   189 HFSFKNLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDS 253
            .|....:||.:|||||||.||:|||.||.||||||:..|.|.|:.|:.||..|||::|||.||:|
Human   275 RFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFES 339

  Fly   254 ICNNKWFTDTSIILFLNKKDLFEEKI--RKSPLTICFPEYT-------GGQEYGEAAAYIQAQFE 309
            |.||:|....||||||||:|:..||:  .||.:...||||.       ...:.||.....:|:|.
Human   340 IWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPKVTRAKFF 404

  Fly   310 AKNK----STSK---EIYC--HMTCATDTNNIQFVFDAVTDVIIANNLR 349
            .::.    ||:.   :.||  |.|||.||.||:.||:...|:|...:|:
Human   405 IRDLFLRISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLK 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	151/333 (45%)
GNAL	NP_892023.1	G-alpha	120..452	CDD:206639	151/333 (45%)