DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphao and GNAI1

DIOPT Version :9

Sequence 1:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_002060.4	Gene:	GNAI1 / 2770	HGNCID:	4384	Length:	354	Species:	Homo sapiens

Alignment Length:	356	Identity:	247/356 - (69%)
Similarity:	295/356 - (82%)	Gaps:	4/356 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65
            |||..|||::||..||::|:|||:|||.:||:::||||||||||||||||||||||||:|::.|:
Human     1 MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEE 65

  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPF-SEELLAAMK 129
            .|||:.|||||||||::||:|||..|.|.:.::.|..||:.:|.:.....  |.| :.||...:|
Human    66 CKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAE--EGFMTAELAGVIK 128

  Fly   130 RLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKN 194
            |||:|:|||.||:||.||||||||.|:|:||||:...:|.||:||:||||||||||||.||:||:
Human   129 RLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKD 193

  Fly   195 LNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKW 259
            |:||:||||||||||||||||||.|||||||||:|:||.||.|||..|||.||:|||||||||||
Human   194 LHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKW 258

  Fly   260 FTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKNK-STSKEIYCHM 323
            ||||||||||||||||||||:|||||||:|||.|...|.|||||||.|||..|| ..:||||.|.
Human   259 FTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHF 323

  Fly   324 TCATDTNNIQFVFDAVTDVIIANNLRGCGLY 354
            ||||||.|:||||||||||||.|||:.|||:
Human   324 TCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	223/315 (71%)
GNAI1	NP_002060.4	G-alpha	34..348	CDD:206639	223/315 (71%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	173..181		6/7 (86%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	196..205		7/8 (88%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	265..272		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R506
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860