Protein Alignment Galphao and GNA15

DIOPT Version :10

• Sequence 1: NP_523684.2
• Gene: Galphao / 36104
• FlyBaseID: FBgn0001122
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_002059.3
• Gene: GNA15 / 2769
• HGNCID: 4383
• Length: 374
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 158/354 - (44%)
• Similarity: 219/354 - (61%)
• Gaps: 15/354 - (4%)

  Fly     8 EERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAEDFKQYRPV 72
            :|:|||...:.|.|.|.|...|...::||||||.|||||||.:|||:|||.:|::.|:.|.:||:
Human    17 DEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEERKGFRPL 81

  Fly    73 VYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPFSEELLAAMKRLWQDAGV 137
            ||.|...|:.|::.||..|.|.:|..|.:..|.:|  :.|..:....|.:...|||:.||:|||:
Human    82 VYQNIFVSMRAMIEAMERLQIPFSRPESKHHASLV--MSQDPYKVTTFEKRYAAAMQWLWRDAGI 144

  Fly   138 QECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNLNFKLFDV 202
            :.|:.|..|:.|.|||.|:|..|:|:..:.|.||.||:||:|:.||||.|..||.:..|.::.||
Human   145 RACYERRREFHLLDSAVYYLSHLERITEEGYVPTAQDVLRSRMPTTGINEYCFSVQKTNLRIVDV 209

  Fly   203 GGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWFTDTSIIL 267
            |||:|||||||||||:|.|:|:..::|||||.|.|:...|||:|||.||.:|....||..||:||
Human   210 GGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLALFGTILELPWFKSTSVIL 274

  Fly   268 FLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAA-------------AYIQAQFEAKNKSTSKEI 319
            ||||.|:.||||..|.|...||.:.|.::..|||             ..:.....:|..:.|:.:
Human   275 FLNKTDILEEKIPTSHLATYFPSFQGPKQDAEAAKRFILDMYTRMYTGCVDGPEGSKKGARSRRL 339

  Fly   320 YCHMTCATDTNNIQFVFDAVTDVIIANNL 348
            :.|.||||||.||:.||..|.|.::|..|
Human   340 FSHYTCATDTQNIRKVFKDVRDSVLARYL 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	148/326 (45%)
GNA15	NP_002059.3	G_alpha	22..372	CDD:214595	155/349 (44%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	44..57		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	181..189		4/7 (57%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	204..213		4/8 (50%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	273..280		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	344..349		4/4 (100%)