DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphao and GNA12

DIOPT Version :9

Sequence 1:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_031379.2	Gene:	GNA12 / 2768	HGNCID:	4380	Length:	381	Species:	Homo sapiens

Alignment Length:	345	Identity:	152/345 - (44%)
Similarity:	218/345 - (63%)	Gaps:	5/345 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAEDFKQYRPVV 73
            ||.|..|||.|:..|..:.....:.:|:||||||||||||.:|||:|||...|..:...::|..:
Human    33 EREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTI 97

  Fly    74 YSNTIQSLVAILRAMPTLSI--QYSNNERESDAKMVFDVCQRMHDTEPFSEEL-LAAMKRLWQDA 135
            :.|.::....::.|...|.|  |||.||:.....|.|:....: ..||.:.:| :.|:..||:|:
Human    98 FDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGL-PVEPATFQLYVPALSALWRDS 161

  Fly   136 GVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNLNFKLF 200
            |::|.|||.:|:||.:|.|||||:|||:|..:|.|::||||..|..|.||||..|..|.:.||:.
Human   162 GIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMV 226

  Fly   201 DVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWFTDTSI 265
            |||||||:|:||..||:.:|:|:|.|:.|||||||.||..|||:.||:.:|::|.|||.|.:.||
Human   227 DVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSI 291

  Fly   266 ILFLNKKDLFEEKIRKSPLTICFPEYTGG-QEYGEAAAYIQAQFEAKNKSTSKEIYCHMTCATDT 329
            ||||||.||..||::...:...||::.|. ....:...|:...|:.|.::.||.::.|.|.|.||
Human   292 ILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDT 356

  Fly   330 NNIQFVFDAVTDVIIANNLR 349
            .|::|||.||.|.|:..||:
Human   357 ENVRFVFHAVKDTILQENLK 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	142/317 (45%)
GNA12	NP_031379.2	G_alpha	42..379	CDD:214595	146/336 (43%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	59..72		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	200..208		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	223..232		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	292..299		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	351..356		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830