DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphao and Gnat3

DIOPT Version :9

Sequence 1:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001074612.1	Gene:	Gnat3 / 242851	MGIID:	3588268	Length:	354	Species:	Mus musculus

Alignment Length:	355	Identity:	208/355 - (58%)
Similarity:	268/355 - (75%)	Gaps:	2/355 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65
            ||...|:|.:.:|.||:.:|:.|:||..:.|:.:|||||||||||||||||||||||::|::.::
Mouse     1 MGSGISSESKESARRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNGYSKQE 65

  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPFSEELLAAMKR 130
            ..:::.|:||||:||::||::||.||.|.|.|.....|.:.:..:...:.|.: .:.:|...:||
Mouse    66 CMEFKAVIYSNTLQSILAIVKAMATLGIDYVNPRSREDQEQLHSMANTLEDGD-MTPQLAEIIKR 129

  Fly   131 LWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNL 195
            ||.|.|:|.||.|::||||||||.|:|:|||||.|..|.|.|||:|.:|||||||:|..||||:|
Mouse   130 LWGDPGIQACFERASEYQLNDSAAYYLNDLDRLTAPGYVPNEQDVLHSRVKTTGIIETQFSFKDL 194

  Fly   196 NFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWF 260
            ||::||||||||||||||||||.||.||||.|:|.||.||.|||..|||.|||.||:||||:|:|
Mouse   195 NFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYF 259

  Fly   261 TDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKN-KSTSKEIYCHMT 324
            ..|||:|||||||||:||:.|..|:||||||||...:.:|..||:.||...| |...||||.|||
Mouse   260 ATTSIVLFLNKKDLFQEKVAKVHLSICFPEYTGPNTFEDAGNYIKNQFLDLNLKKEDKEIYSHMT 324

  Fly   325 CATDTNNIQFVFDAVTDVIIANNLRGCGLY 354
            |||||.|::||||||||:||..||:.|||:
Mouse   325 CATDTQNVKFVFDAVTDIIIKENLKDCGLF 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	191/314 (61%)
Gnat3	NP_001074612.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		9/24 (38%)
		G_alpha	13..352	CDD:214595	201/339 (59%)
		G-alpha	34..348	CDD:206639	191/314 (61%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	173..181		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	196..205		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	265..272		5/6 (83%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54330
OrthoDB	1	1.010	-	-		D406662at33208
OrthoFinder	1	1.000	-	-		FOG0000052
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100285
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X53
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730