DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphao and Gnas

DIOPT Version :9

Sequence 1:	NP_523684.2	Gene:	Galphao / 36104	FlyBaseID:	FBgn0001122	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_034439.2	Gene:	Gnas / 14683	MGIID:	95777	Length:	1133	Species:	Mus musculus

Alignment Length:	380	Identity:	163/380 - (42%)
Similarity:	218/380 - (57%)	Gaps:	43/380 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAE-------- 64
            ::||...||:||::.|:|:.:......:||||||||||||||||||:|:|.:||..|
Mouse   754 QKRADKKRSKLIDKQLEEEKMDYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQA 818

  Fly    65 -----DFKQYRPV--VYSNTIQSLVAILRAMPTL--SIQYSNNERESDAKMVFDVCQRMHDTEP- 119
                 |.::...|  :.:|..:::..|:.||..|  .::.:|.|.:.....:..|.     ..|
Mouse   819 ARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVM-----NVPN 878

  Fly   120 --FSEELLAAMKRLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKT 182
              |..|.....|.||:|.||:.|:.|||||||.|.|:||||.:|.:...||.|::||:||.||.|
Mouse   879 FDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLT 943

  Fly   183 TGIVEVHFSFKNLNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQES 247
            :||.|..|....:||.:|||||||.||:|||.||.|||||||.||.|.|:.|:.||..|||:||:
Mouse   944 SGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEA 1008

  Fly   248 LKLFDSICNNKWFTDTSIILFLNKKDLFEEKI--RKSPLTICFPE---YTGGQ----EYGE---- 299
            |.||.||.||:|....|:||||||:||..||:  .||.:...|||   ||..:    |.||
Mouse  1009 LNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRV 1073

  Fly   300 --AAAYIQAQF-EAKNKSTSKEIYC--HMTCATDTNNIQFVFDAVTDVIIANNLR 349
              |..:|:.:| .....|.....||  |.|||.||.||:.||:...|:|...:||
Mouse  1074 TRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLR 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	153/351 (44%)
Gnas	NP_034439.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..195
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..552
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..744
		G_alpha	759..1130	CDD:214595	161/375 (43%)
		G-alpha	780..1127	CDD:206639	153/351 (44%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	781..794		11/12 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..828		3/20 (15%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	935..943		5/7 (71%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	958..967		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	1027..1034		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	1103..1108		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920