Protein Alignment Galphao and Gnao1

DIOPT Version :10

• Sequence 1: NP_523684.2
• Gene: Galphao / 36104
• FlyBaseID: FBgn0001122
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_034438.1
• Gene: Gnao1 / 14681
• MGIID: 95775
• Length: 354
• Species: Mus musculus
• Alignment Length: 354
• Identity: 287/354 - (81%)
• Similarity: 316/354 - (89%)
• Gaps: 0/354 - (0%)

  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65
            |||..|||||||..||:.||:|||||||.||||:||||||||||||||||||||||||.||:.||
Mouse     1 MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGED 65

  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPFSEELLAAMKR 130
            .|||:|||||||||||.||:|||.||.::|.:.||::|:|||.||..||.||||||.|||:||.|
Mouse    66 VKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKTDSKMVCDVVSRMEDTEPFSAELLSAMMR 130

  Fly   131 LWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKNL 195
            ||.|:|:||||:||.||||||||||:||.|||:||.|||||||||||||||||||||.||:||||
Mouse   131 LWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAGDYQPTEQDILRTRVKTTGIVETHFTFKNL 195

  Fly   196 NFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKWF 260
            :|:|||||||||||||||||||||||||||||:|.||||||||||||||.|||.|||||||||:|
Mouse   196 HFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFF 260

  Fly   261 TDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKNKSTSKEIYCHMTC 325
            .||||||||||||||.|||:|||||||||||.|...|.:||||||.|||:||:|.:|||||||||
Mouse   261 IDTSIILFLNKKDLFGEKIKKSPLTICFPEYPGSNTYEDAAAYIQTQFESKNRSPNKEIYCHMTC 325

  Fly   326 ATDTNNIQFVFDAVTDVIIANNLRGCGLY 354
            ||||||||.|||||||:||||||||||||
Mouse   326 ATDTNNIQVVFDAVTDIIIANNLRGCGLY 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	254/313 (81%)
Gnao1	NP_034438.1	G-alpha	34..348	CDD:206639	254/313 (81%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		7/7 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)