Protein Alignment Galphao and Gnai1

DIOPT Version :10

• Sequence 1: NP_523684.2
• Gene: Galphao / 36104
• FlyBaseID: FBgn0001122
• Length: 354
• Species: Drosophila melanogaster
• Sequence 2: NP_034435.1
• Gene: Gnai1 / 14677
• MGIID: 95771
• Length: 354
• Species: Mus musculus
• Alignment Length: 356
• Identity: 247/356 - (69%)
• Similarity: 295/356 - (82%)
• Gaps: 4/356 - (1%)

  Fly     1 MGCAQSAEERAAAARSRLIERNLKEDGIQAAKDIKLLLLGAGESGKSTIVKQMKIIHESGFTAED 65
            |||..|||::||..||::|:|||:|||.:||:::||||||||||||||||||||||||:|::.|:
Mouse     1 MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEE 65

  Fly    66 FKQYRPVVYSNTIQSLVAILRAMPTLSIQYSNNERESDAKMVFDVCQRMHDTEPF-SEELLAAMK 129
            .|||:.|||||||||::||:|||..|.|.:.::.|..||:.:|.:.....  |.| :.||...:|
Mouse    66 CKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAE--EGFMTAELAGVIK 128

  Fly   130 RLWQDAGVQECFSRSNEYQLNDSAKYFLDDLDRLGAKDYQPTEQDILRTRVKTTGIVEVHFSFKN 194
            |||:|:|||.||:||.||||||||.|:|:||||:...:|.||:||:||||||||||||.||:||:
Mouse   129 RLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKD 193

  Fly   195 LNFKLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSEYDQVLHEDETTNRMQESLKLFDSICNNKW 259
            |:||:||||||||||||||||||.|||||||||:|:||.||.|||..|||.||:|||||||||||
Mouse   194 LHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKW 258

  Fly   260 FTDTSIILFLNKKDLFEEKIRKSPLTICFPEYTGGQEYGEAAAYIQAQFEAKNK-STSKEIYCHM 323
            ||||||||||||||||||||:|||||||:|||.|...|.|||||||.|||..|| ..:||||.|.
Mouse   259 FTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHF 323

  Fly   324 TCATDTNNIQFVFDAVTDVIIANNLRGCGLY 354
            ||||||.|:||||||||||||.|||:.|||:
Mouse   324 TCATDTKNVQFVFDAVTDVIIKNNLKDCGLF 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphao	NP_523684.2	G-alpha	34..348	CDD:206639	223/315 (71%)
Gnai1	NP_034435.1	G-alpha	34..348	CDD:206639	223/315 (71%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		12/12 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	173..181		6/7 (86%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	196..205		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	265..272		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		4/4 (100%)