DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RanBPM and Spryd3

DIOPT Version :9

Sequence 1:	NP_001303342.1	Gene:	RanBPM / 36102	FlyBaseID:	FBgn0262114	Length:	1127	Species:	Drosophila melanogaster
Sequence 2:	NP_001028449.2	Gene:	Spryd3 / 223918	MGIID:	2446175	Length:	442	Species:	Mus musculus

Alignment Length:	381	Identity:	80/381 - (20%)
Similarity:	136/381 - (35%)	Gaps:	124/381 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 EVASV-SGAQRLHSVAVLPRYSSASRAPRSSNNNNNNISNHNNNNNNSNSNSLSRR--------- 347
            ||:.| ||.:...:|.::|:|.|....|   ....::::.|.::....|..:..|:
Mouse    82 EVSIVDSGVRGTIAVGLVPQYYSLDHQP---GWLPDSVAYHADDGKLYNGRAKGRQFGSKCNSGD 143

  Fly   348 ---------------TRHFYSNNGSHFSNDMFPSHNPRSSTQTSSPRVGGRRHHSTPAASSNSPQ 397
                           .:.|::.||....:.:.|     .|.....|.||               .
Mouse   144 RIGCGIEPVSFDVQTAQIFFTKNGKRVGSTIMP-----MSPDGLFPAVG---------------M 188

  Fly   398 HQGVDPLRL-LYPNVNESETPLPRCWSPHDKCLSIGLSQNNLRV-----TYKGVGKQHSDAASVR 456
            |...:.:|| |...:...:..:....|..|:...:    :::||     .|.|.||...|....:
Mouse   189 HSLGEEVRLHLNAELGREDDSVMMVDSYEDEWGRL----HDVRVCGTLLEYLGKGKSIVDVGLAQ 249

  Fly   457 TAYPIPSSCGLYYFEVRIISKGRNGYMGIGLTAQQFRMNRLPGWDKQSYGYHGDDGNSFSSSGNG 521
            ..:|:  |...:||||.|:..|...|:.:||..:.:..||.|||.:.|..||.|||..|..||.|
Mouse   250 ARHPL--STRSHYFEVEIVDPGEKCYIALGLARKDYPKNRHPGWSRGSVAYHADDGKIFHGSGVG 312

  Fly   522 QTYGPTFTTGDVIGCCVNF-----------VNNTC------------------------------ 545
            ..:||....||::||.:.|           .:::|
Mouse   313 DPFGPRCYKGDIMGCGIMFPRDYILDSEGDSDDSCDTVILSPTARAVRNVRNVMYLHQEGEEEEE 377

  Fly   546 ----------------------FYTKNGVDLGIAFRDLPT-KLYPTVGLQTPGEEV 578
                                  |:|:||..:|.....:|: ..:||:|:.:.||:|
Mouse   378 EEEEEEDGEEIEQEHEGKKVVVFFTRNGKIIGKKDAVVPSGGFFPTIGMLSCGEKV 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RanBPM	NP_001303342.1	Extensin_2	55..103	CDD:252669
		Involucrin2	137..188	CDD:284425
		SPRY_RanBP9_10	442..584	CDD:293966	51/201 (25%)
		CLTH	655..938	CDD:287564
		CTLH	655..711	CDD:128914
		CRA	846..944	CDD:214806
Spryd3	NP_001028449.2	SPRYD3	43..200	CDD:293965	24/140 (17%)
Spryd3	NP_001028449.2	SPRYD3	220..438	CDD:293965	53/220 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1477
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106989at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820