DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RanBPM and Y54E5A.7

DIOPT Version :9

Sequence 1:	NP_001303342.1	Gene:	RanBPM / 36102	FlyBaseID:	FBgn0262114	Length:	1127	Species:	Drosophila melanogaster
Sequence 2:	NP_001252408.1	Gene:	Y54E5A.7 / 173332	WormBaseID:	WBGene00013202	Length:	622	Species:	Caenorhabditis elegans

Alignment Length:	538	Identity:	163/538 - (30%)
Similarity:	250/538 - (46%)	Gaps:	86/538 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 NSPQHQGVDPLRLLYPNV--NESETPLPRCWSPHDKCLSIGLSQNNLRVTYK---GVGKQHSDAA 453
            |...|:....||.|||.:  .|:|..:||.|........:.:||:...||:|   .|.:....|.
Worm    17 NQDPHETNLALRRLYPQIRERENERHIPRRWDLRQASSYLDISQSGYGVTFKKNVTVAEDKDPAG 81

  Fly   454 SVRTAYPIPSSCGLYYFEVRIISKGRNGYMGIGLTAQQFRMNRLPGWDKQSYGYHGDDGNSFSSS 518
            .||....|....|:|||||||: :|.:|.|||||:.:...:||:||||...:||||||||.|.:|
Worm    82 VVRADAFIQQCIGVYYFEVRIL-EGHSGCMGIGLSKKDCDLNRMPGWDPGCFGYHGDDGNFFLAS 145

  Fly   519 GNGQTYGPTFTTGDVIGCCVNFVNNTCFYTKNGVDLGIAFRDLPT---KLYPTVGLQTPGEEVDA 580
            |.||.|||.|..||||||.::...:..|:||||..||||... ||   :||||||.:|.||::.|
Worm   146 GVGQAYGPKFGPGDVIGCGIDTFYHYVFFTKNGKHLGIAHTS-PTALKELYPTVGFKTRGEKLVA 209

  Fly   581 NFGQEPFKFDKIVDMMKEMRSNVL-RKIDRYPHLLET---PENL---MNRLVSTYLVHNAFSKTA 638
            |||.:||:||     .:..|.::: :||    ||||.   |||.   |||:||::|.......|.
Worm   210 NFGVKPFEFD-----FEAYRQHLMNKKI----HLLENIKMPENFGKQMNRIVSSFLGTTGALATL 265

  Fly   639 EAFNGYTNQTFNEDLASIKTRQKIIKLILTGKMSQAIEHTL-RSFPGLLENNKNLWFALKCRQFI 702
            :.|...|......|......|::|..:||.......|...: :.||||:|::.|:...:.|.::|
Worm   266 QKFEETTKPEVPIDHEYYAQRKEITDMILKAARGAEIHEKIEKYFPGLVEDDANVHLLILCLRYI 330

  Fly   703 EMINGADIENVNNKVTATTQTMPTN-----------QTSVIQSTKTFKHSKSGSGNGNVNINQTQ 756
            ::.|... |..|....:||...|:.           :.|..::||..:.::..|.|..|:.....
Worm   331 DLANTLH-EPPNCFTNSTTGRSPSPTEIRARPPKLLKGSQCKTTKRTREAQRRSANSQVHTPPPV 394

  Fly   757 QQNNTAIPAVIKPQGGDRPDIKNMLVDDNSNKCVEH-DSNSMD----VEMEPCQSHSNGGDSSSN 816
            :..|......:..:..   .|:...:|.::.:.:.| |..||.    ||:|....:
Worm   395 RLTNAKATEELYLKDA---KIERFYIDQDTEEEMLHIDGVSMPTKMFVELEKSGQY--------- 447

  Fly   817 GNASAVRNSLDAIDEEMDVSPSSRNCGRVIEKILEFGKELSSMGQQLEKENLMTEEERQMLEDAF 881
                                       |.:..||:.|:|:..:..::...  :..|.|:::|.|.
Worm   448 ---------------------------RKLNYILKMGREIMKVAGEMRGN--IAPEARKVVEIAT 483

  Fly   882 SLIAY-SNPWSSPLGWLL 898
            |:::. ..|...||.:.|
Worm   484 SMVSSPERPAKHPLSFAL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RanBPM	NP_001303342.1	Extensin_2	55..103	CDD:252669
		Involucrin2	137..188	CDD:284425
		SPRY_RanBP9_10	442..584	CDD:293966	73/147 (50%)
		CLTH	655..938	CDD:287564	49/262 (19%)
		CTLH	655..711	CDD:128914	14/56 (25%)
		CRA	846..944	CDD:214806	13/54 (24%)
Y54E5A.7	NP_001252408.1	SPRY	75..212	CDD:295394	70/138 (51%)
Y54E5A.7	NP_001252408.1	CTLH	282..340	CDD:128914	15/58 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I3230
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001704
OrthoInspector	1	1.000	-	-		oto19030
orthoMCL	1	0.900	-	-		OOG6_102407
Panther	1	1.100	-	-	LDO	PTHR12864
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4441
SonicParanoid	1	1.000	-	-		X1611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.940