DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RanBPM and RANBP9

DIOPT Version :9

Sequence 1:	NP_001303342.1	Gene:	RanBPM / 36102	FlyBaseID:	FBgn0262114	Length:	1127	Species:	Drosophila melanogaster
Sequence 2:	NP_005484.2	Gene:	RANBP9 / 10048	HGNCID:	13727	Length:	729	Species:	Homo sapiens

Alignment Length:	908	Identity:	342/908 - (37%)
Similarity:	441/908 - (48%)	Gaps:	235/908 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 QTAPPPTTSSTAPQRDEREQQQQQEAPPLQQDQQENSPAQDQELHPLLDQQNQEYPAVHQDQQAE 162
            |..|||      ||   ::|||||.:||        .||   .|.|:........|||
Human     4 QPPPPP------PQ---QQQQQQQLSPP--------PPA---ALAPVSGVVLPAPPAV------- 41

  Fly   163 QNQELHHIEGLIRHRESQNPEEHPPQASLENRETLGREDT-----NQEPDEPQVRDPEIEPEAEP 222
                          ....:|...|...:  ..|.||....     ...|..|....|   |...|
Human    42 --------------SAGSSPAGSPGGGA--GGEGLGAAAAALLLHPPPPPPPATAAP---PPPPP 87

  Fly   223 PPPLLLEDLDEQDSGSQDLNEQQPPLIIDANAIAETIDANAVERIDDYEDDDEEVDEEEEVVEDR 287
            |||                    ||    |:|.|......|
Human    88 PPP--------------------PP----ASAAAPASGPPA------------------------ 104

  Fly   288 VDRAGEVASVSGAQRLHSVAVLPRYSSASRAPRSSNNNNNNISNHNNNNNNSNSNSLSRRTRHFY 352
              ..|..|....|....:.|::...|:|:..|            |.::..|.....|.||
Human   105 --PPGLAAGPGPAGGAPTPALVAGSSAAAPFP------------HGDSALNEQEKELQRR----- 150

  Fly   353 SNNGSHFSNDMFPSHNPRSSTQTSSPRVGGRRHHSTPAASSNSPQHQGVDPLRLLYPNVNESETP 417
                                                               |:.|||.|:|.|||
Human   151 ---------------------------------------------------LKRLYPAVDEQETP 164

  Fly   418 LPRCWSPHDKCLSIGLSQNNLRVTYKGVGKQHSDAASVRTAYPIPSSCGLYYFEVRIISKGRNGY 482
            |||.|||.||...||||||||||.|||.||...||||||..:|||::||:|||||:|:||||:||
Human   165 LPRSWSPKDKFSYIGLSQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGY 229

  Fly   483 MGIGLTAQQFRMNRLPGWDKQSYGYHGDDGNSFSSSGNGQTYGPTFTTGDVIGCCVNFVNNTCFY 547
            |||||:||...|||||||||.|||||||||:||.|||.||.||||||||||||||||.:||||||
Human   230 MGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFY 294

  Fly   548 TKNGVDLGIAFRDLPTKLYPTVGLQTPGEEVDANFGQEPFKFDKIVDMMKEMRSNVLRKIDRYPH 612
            ||||..|||||.|||..||||||||||||.|||||||.||.|| |.|.|:|.|:.:..:|||:|.
Human   295 TKNGHSLGIAFTDLPPNLYPTVGLQTPGEVVDANFGQHPFVFD-IEDYMREWRTKIQAQIDRFPI 358

  Fly   613 LLETPE--NLMNRLVSTYLVHNAFSKTAEAFNGYTNQTFNEDLASIKTRQKIIKLILTGKMSQAI 675
            .....|  .::.::||:||||:.:..|||||...|:||..|:|||||.||:|.||:|.|:|.:||
Human   359 GDREGEWQTMIQKMVSSYLVHHGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMGEAI 423

  Fly   676 EHTLRSFPGLLENNKNLWFALKCRQFIEMINGADIENVNNKVTATTQTMPTNQTSVIQSTKTFK- 739
            |.|.:.:|.|||.|.||.|.||.||||||:||.|.|     |.......|.:|.|...|.:.|.
Human   424 ETTQQLYPSLLERNPNLLFTLKVRQFIEMVNGTDSE-----VRCLGGRSPKSQDSYPVSPRPFSS 483

  Fly   740 -----------HS-KSGSG------------NGNVNINQTQ--------QQNNTAIPAVIKPQGG 772
                       |: .||.|            ||.::....|        |.:|..:|.:
Human   484 PSMSPSHGMNIHNLASGKGSTAHFSGFESCSNGVISNKAHQSYCHSNKHQSSNLNVPEL------ 542

  Fly   773 DRPDIKNMLVDDNSNKCVEHDSNSMDVEMEPCQSHSNG-GDSSSNG--NASAVR-NSLDAIDEEM 833
                  |.:....|.:.....||.:|:|.:   .:||| |::||||  |.|:.. :.::..|.||
Human   543 ------NSINMSRSQQVNNFTSNDVDMETD---HYSNGVGETSSNGFLNGSSKHDHEMEDCDTEM 598

  Fly   834 DVSPSS---RNCG---RVIEKILEFGKELSSMGQQLEKENLMTEEERQMLEDAFSLIAYSNPWSS 892
            :|..|.   :.||   ..||:::.||:||.:|.:||.::.......::||:|||||:|||:||:|
Human   599 EVDSSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRDCGKNTANKKMLKDAFSLLAYSDPWNS 663

  Fly   893 PLGWLLCPSRRESVSTTLNSAILESLNFERRPPLEYLVAHASELIKVIGQHSLGEDAFITIDD 955
            |:|..|.|.:||.|.:.|||||||:.|..::|||...:..|::.:.::.:..:|..||.|::|
Human   664 PVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAMGQATQCLGLMARSGIGSCAFATVED 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RanBPM	NP_001303342.1	Extensin_2	55..103	CDD:252669	2/4 (50%)
		Involucrin2	137..188	CDD:284425	7/50 (14%)
		SPRY_RanBP9_10	442..584	CDD:293966	111/141 (79%)
		CLTH	655..938	CDD:287564	115/325 (35%)
		CTLH	655..711	CDD:128914	34/55 (62%)
		CRA	846..944	CDD:214806	41/97 (42%)
RANBP9	NP_005484.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..137		47/240 (20%)
		SPRY_RanBP9_10	189..331	CDD:293966	111/141 (79%)
		LisH	364..397	CDD:128913	14/32 (44%)
		Interaction with CALB1. /evidence=ECO:0000305	401..407		5/5 (100%)
		CTLH	403..459	CDD:128914	34/55 (62%)
		CLTH	403..>457	CDD:287564	33/53 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..489		5/27 (19%)
		Interaction with FMR1. /evidence=ECO:0000269\|PubMed:15381419	615..729		46/112 (41%)
		CRA	616..708	CDD:214806	41/91 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156829
Domainoid	1	1.000	214	1.000	Domainoid score	I2731
eggNOG	1	0.900	-	-		E1_KOG1477
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38057
Inparanoid	1	1.050	514	1.000	Inparanoid score	I1311
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106989at2759
OrthoFinder	1	1.000	-	-		FOG0001704
OrthoInspector	1	1.000	-	-		otm40348
orthoMCL	1	0.900	-	-		OOG6_102407
Panther	1	1.100	-	-	LDO	PTHR12864
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4441
SonicParanoid	1	1.000	-	-		X1611
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790