Protein Alignment AQP4 and Eglp4

DIOPT Version :10

• Sequence 1: NP_001304313.1
• Gene: AQP4 / 361
• HGNCID: 637
• Length: 352
• Species: Homo sapiens
• Sequence 2: NP_001261154.1
• Gene: Eglp4 / 37739
• FlyBaseID: FBgn0034885
• Length: 297
• Species: Drosophila melanogaster
• Alignment Length: 309
• Identity: 93/309 - (30%)
• Similarity: 143/309 - (46%)
• Gaps: 49/309 - (15%)

Human     8 RRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIF---------VLLSLGSTINWG--- 60
            :||...   |.||.     ..:::.|.:|..:..|....:|         :...||..|..|
  Fly    15 KRWTMA---CDREG-----SSLFSVALFKRFSDHFSCCKVFKMKGSTLDKISAFLGELIGTGILV 71

Human    61 -----GTEKP--LPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFY 118
                 |..|.  .|.:.:.|.|.||.::...:||||.:||.|:|||||||......:::..:..|
  Fly    72 FLGCMGCVKTDLFPNNHLQIVLNFGFAVLIAIQCFGCVSGAHLNPAVTVAAYIYEMVTLRMAFAY 136

Human   119 IAAQCLGAIIGAGILYLVTPP---SVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDS 180
            .|||.|||.||.|:|.::.|.   :|..||.||:.|.::|.|..|.:|.:||..||.......|.
  Fly   137 FAAQMLGAFIGYGLLMVLLPSPTLTVGAGLCVTLPHTSVTTGQALGIEFVITSILVIVCCGVWDP 201

Human   181 KRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAG 245
            :.:....|:.:..|.::|.....|..:||.||||||||.||:...::|::||||:.|:..:.:..
  Fly   202 RNSKFHDSVGIRFGLAIACLACAAGPFTGGSMNPARSFAPALWNKHFESNWIYWLAPLSSSAITA 266

Human   246 GLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLIL 294
            ..|:.|      |:|...||             |:..|....:.:|:.|
  Fly   267 YAYKVV------FRREVVEA-------------EITSNEKLRQLEDVQL 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AQP4	NP_001304313.1	MIP	31..248	CDD:395174	78/238 (33%)
Eglp4	NP_001261154.1	MIP	59..272	CDD:444743	75/212 (35%)