Protein Alignment AQP4 and Eglp2

DIOPT Version :10

• Sequence 1: NP_001304313.1
• Gene: AQP4 / 361
• HGNCID: 637
• Length: 352
• Species: Homo sapiens
• Sequence 2: NP_788433.2
• Gene: Eglp2 / 37737
• FlyBaseID: FBgn0034883
• Length: 290
• Species: Drosophila melanogaster
• Alignment Length: 264
• Identity: 90/264 - (34%)
• Similarity: 130/264 - (49%)
• Gaps: 25/264 - (9%)

Human     2 SDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFL--AMLIFVLLSLGSTINWGGTEK 64
            |.:.|.|....|..|..|:...:.           .|.||.:  |||:| |..:||..|...|..
  Fly    24 SGKQTCRSQSNCWLLQRRQLDSIT-----------TVLAEMIATAMLMF-LGCMGSVENSVFTNS 76

Human    65 PLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIG 129
            ...     .:|.||..:...:||||.:.|.|:|||||:|......||:..::.|..||.:||.||
  Fly    77 DFQ-----SALNFGFVVLICIQCFGCVCGAHLNPAVTLATYVYNMISLPMALAYFVAQMVGAFIG 136

Human   130 AGILYLVTPPSVV------GGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGS 188
            .|:|..|.|.|.:      .|:.:|.::..||...||.||.:||..|:.......|.:......|
  Fly   137 YGLLKAVLPESAIYSAENPNGVCLTSLNSTLTPWQGLAVEFLITCVLISVCCGVWDPRNATKQDS 201

Human   189 IALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFC 253
            :.:..|.::|...|.|...|||||||.|||.||:..|.|::||||||||:..|::...:|::.|.
  Fly   202 LPVRFGLAIACLSLTAGQLTGASMNPVRSFAPAIWNGFWDDHWIYWVGPMAAALITSVIYKHAFR 266

Human   254 PDVE 257
            .::|
  Fly   267 RELE 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AQP4	NP_001304313.1	MIP	31..248	CDD:395174	81/224 (36%)
Eglp2	NP_788433.2	MIP	41..261	CDD:444743	82/236 (35%)