Protein Alignment AQP4 and Drip

DIOPT Version :10

• Sequence 1: NP_001304313.1
• Gene: AQP4 / 361
• HGNCID: 637
• Length: 352
• Species: Homo sapiens
• Sequence 2: NP_001260893.1
• Gene: Drip / 36236
• FlyBaseID: FBgn0015872
• Length: 278
• Species: Drosophila melanogaster
• Alignment Length: 234
• Identity: 101/234 - (43%)
• Similarity: 138/234 - (58%)
• Gaps: 13/234 - (5%)

Human    23 MVAFKGV----WTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIAT 83
            |..|.||    ..:..|:.:..|.:.....:.:.:|||     |...:|    .|:..|||::||
  Fly     7 MSKFVGVADITENKKIWRMLLGELVGTFFLIFVGVGST-----TSGSVP----QIAFTFGLTVAT 62

Human    84 MVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVT 148
            :.|..||:||.|||||||:..:...:|||.|:.|||..||:|||.||.::.:.......|.|||:
  Fly    63 IAQGLGHLSGCHINPAVTLGFLIVGEISILKAAFYIIVQCVGAIAGAAVIKVALDGVAGGDLGVS 127

Human   149 MVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMN 213
            ....:|.....:|:|.:|||.|||.:.|..|..|.|:.||..||:|.::|.|||.||..:|||||
  Fly   128 SFDPSLNCAQAVLIEALITFILVFVVKAVSDPGRQDIKGSAPLAVGLAIAAGHLCAIKLSGASMN 192

Human   214 PARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVF 252
            |||||||||:.|.|..||:||||||.|.:|||.:|..:|
  Fly   193 PARSFGPAVVQGVWTYHWVYWVGPIAGGLLAGIIYRLIF 231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AQP4	NP_001304313.1	MIP	31..248	CDD:395174	95/216 (44%)
Drip	NP_001260893.1	MIP	23..227	CDD:444743	95/212 (45%)