Protein Alignment Prx6c and PRDX6

DIOPT Version :10

• Sequence 1: NP_523683.1
• Gene: Prx6c / 36098
• FlyBaseID: FBgn0033518
• Length: 220
• Species: Drosophila melanogaster
• Sequence 2: NP_004896.1
• Gene: PRDX6 / 9588
• HGNCID: 16753
• Length: 224
• Species: Homo sapiens
• Alignment Length: 216
• Identity: 116/216 - (53%)
• Similarity: 149/216 - (68%)
• Gaps: 2/216 - (0%)

  Fly     3 LGQTVPNFEADTTKGPIKFHEWQGNSWVVLFSHPADFTPVCTTELGRIAVHQPEFAKRNTKCLAH 67
            ||...|||||:||.|.|:||::.|:||.:|||||.||||||||||||.|...|||||||.|.:|.
Human     7 LGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKRNVKLIAL 71

  Fly    68 SVDALNSHVDWVNDIKSYCLDIPGD-FPYPIIADPTRDLAVSLGMLDEEQKKDPEVGKTIRALFI 131
            |:|::..|:.|..||.:|..:.|.: .|:|||.|..|:||:.|||||..:|.:..:..|.|.:|:
Human    72 SIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPAEKDEKGMPVTARVVFV 136

  Fly   132 ISPDHKVRLSMFYPMSTGRNVDEILRTIDSLQLTDRLKVVATPANWTPGTKVMILPTVTDEEAHK 196
            ..||.|::||:.||.:||||.|||||.:.|||||.. |.||||.:|..|..||:|||:.:|||.|
Human   137 FGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAE-KRVATPVDWKDGDSVMVLPTIPEEEAKK 200

  Fly   197 LFPKGFDKVSMPSGVNYVRTT 217
            |||||.....:|||..|:|.|
Human   201 LFPKGVFTKELPSGKKYLRYT 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prx6c	NP_523683.1	PRX_1cys	3..218	CDD:239314	116/216 (54%)
PRDX6	NP_004896.1	PRX_1cys	7..222	CDD:239314	116/216 (54%)
		Required and sufficient for targeting to lysosomes and lamellar bodies. /evidence=ECO:0000250|UniProtKB:O35244	31..40		5/8 (63%)