DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ndg and mgl

DIOPT Version :10

Sequence 1:NP_610575.1 Gene:Ndg / 36089 FlyBaseID:FBgn0026403 Length:1350 Species:Drosophila melanogaster
Sequence 2:NP_572563.3 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster


Alignment Length:1506 Identity:330/1506 - (21%)
Similarity:535/1506 - (35%) Gaps:437/1506 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 YASIAAFYSNVDTSFSDEGTSISLFESKEQSI-LDRASSLVRYAFSSQSEFEARQVIVATWRNVG 165
            ||....::|::.|             .|.||: ||..:..|       |.|:  |.:..||..|.
  Fly   533 YARNTLYWSDIKT-------------RKVQSLPLDAQNKAV-------SPFD--QTLPGTWAPVA 575

  Fly   166 -----------YFDSKTDRLNTFQV----------------ALIANEQSTFVQFIYPDGGLNWLQ 203
                       ..|....:::.|::                |.:|.:.:..:.|: .||| ..|:
  Fly   576 LAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADLALDPTAGLMFV-ADGG-QVLR 638

  Fly   204 GETAGLGLPDIRAQAGFVAE--------------------------DG--RFYTLNG----SGS- 235
            ....|.....|.::|.:.|.                          :|  |...|.|    |.| 
  Fly   639 AHMDGTHARSIVSEAAYKASGVTVDIISKRVFWCDSLLDYIESVDYEGAHRVMVLRGQQVPSPSR 703

  Fly   236 ----ENARFLSESTNLGVPGVWLFE----VAPIENEQNVRSPDN--AESLTESPALALSCQAHAH 290
                ||..:.:::|..|:..|..||    :......:::|.|..  |......|.::..|..:..
  Fly   704 LALFENRIYWTDATKQGIMSVDKFEGPTSIQVTYKAKDIREPKGIIAVHALSQPRVSNPCGNNNG 768

  Fly   291 QCHEKAECHDKAE-------GYCCVCGSGFYGNGKSCLANDQPIRVTGTLTGELNKQPVSEEAKL 348
            .|:..  |...|.       |:.|.|.:|:.      |..|..:           .:||||    
  Fly   769 GCNHM--CIVTAVKGAPTGLGFRCACSTGYQ------LETDLKL-----------CKPVSE---- 810

  Fly   349 QSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANGYQLTGGVYTHVSRLQ 413
              :::.|:.| :.....|.|.:......::|:::.    .|:.||                  |.
  Fly   811 --FLMYSQQR-FIKGKVLEPVIEGFSDAIMPVVSR----RARFVG------------------LD 850

  Fly   414 FDS-GENLHVNQTFEGLNY---WDQLSVKIEIYGEVPAVAADAVLILPDYVEE---YTFERPGEL 471
            ||: .|.::.:...:.:.|   .:....:|.:..:...|...||    |:..:   |...|.|.|
  Fly   851 FDARDEFIYYSDVLQDVIYRVHRNGTGREIVLASQNEGVEGLAV----DWASKNLYYIDSRKGTL 911

  Fly   472 KSVQVLNI--------NITEEQRVLGLQVEQRILYRS------CLRDDEADPSATKVLQKI---- 518
            ..:...|:        |: :..|.:.:...:..::.|      .:.....|.|...|.:.:    
  Fly   912 NVLSTRNVTHRRTLLKNL-KRPRAIVVHPNRGFIFFSEWDRPANITRANTDGSGLLVFKNVTLGW 975

  Fly   519 -SKVALDYVERDQALRIGAMSKVGVTPESNACNDGTADCVENSVCV------------PYEDTYR 570
             :.:::|:.| |:.....|:    :....:|..|||.....||..|            .|...:|
  Fly   976 PNGLSIDFKE-DRVYWCDAL----LDHVQHANLDGTDIKTVNSRLVRHPFSIVIHNDWMYITDWR 1035

  Fly   571 CDC---YHGFAAQLDER-----------GVEV-------CLDIDECATGSHVCDENAVC------ 608
            .|.   .|....:.:|.           ||:|       ..|...|...:..|.:  :|      
  Fly  1036 LDAIIRLHKLTGEQEEMMVREPQTNRLYGVKVYSHEVQRIADTQPCHRNNGGCQK--ICFAVPIG 1098

  Fly   609 --DNTEG------GF-----NCYCTEGFEGNGYRCLSNSTADNIEYPPAVEGQAEPTSEPSPN-- 658
              :.|:|      .|     .|.|..|         .....|.:...|  :..|||..:|.||  
  Fly  1099 ASNGTDGVTTSSPSFGRLQSRCSCPYG---------ERLADDQVSCIP--DPSAEPPVQPCPNSW 1152

  Fly   659 ----------PSPYPDQGQDQEREREDDQYPQPNPYPYPEE-------QIPQHPDECYRCSKDAD 706
                      |..:...|.|...:..|::.....|.....|       .|||:    :||.::.|
  Fly  1153 DFTCNNQRCIPKSWLCDGDDDCLDNSDEEQNCTKPTCGSNEFQCRSGRCIPQN----FRCDQEND 1213

  Fly   707 CYQGRCTCHEGFDGDGYTCTNI-CGHGE-VWENGRCEPLLLERHDVDPLCDALGECRCPYGYELS 769
            |         |.:.|...|.|: ||..: ...||||.|.:.:       ||:..:|    |....
  Fly  1214 C---------GDNSDEQECGNVTCGTSQFACANGRCIPNMWK-------CDSENDC----GDSSD 1258

  Fly   770 ED----SQRCTYVQEFDGERNADLIP----CDVDENCH----------INATCNWYG-QELRH-- 813
            |.    .:.|.|.| |...|....||    ||.|::|.          |:...|.:. .:||.  
  Fly  1259 EGDFCAEKTCAYFQ-FTCPRTGHCIPQSWVCDGDDDCFDKQDEKDCPPISCLANQFKCADLRQCV 1322

  Fly   814 --------ICTCQPGFRGDGYNCDPISDDSCAIRPDI--------------CDVHADCVYEEHLG 856
                    |..|..|  .|...|..:..:.|.:....              ||...||  .:|..
  Fly  1323 EESYKCDGIPDCNDG--SDEVGCPSMGPNQCNLEKHFRCKSTGFCIPIAWHCDGSNDC--SDHSD 1383

  Fly   857 KSEC---QC-QAGYTGNGFNCQLAAE-CQSAEHCGENA-------------FCDDGVCRCQADFE 903
            :.:|   .| |..:..|..||...|. |...:.||:|:             .|..|..:|..   
  Fly  1384 EQDCGQITCAQNFFKCNNTNCVFKAYICDGKDDCGDNSDEGAEHACVPPPFKCPHGQWQCPG--- 1445

  Fly   904 RDVSDRCVPAGRCGSVFCGSNAICKWDSAEGVQYCDCLDGYQGDALTGCTSKPLSCHVLNNCGIH 968
              ||:|||   ...|| |.....|...|.|| :.||         |..|.      |....|.  
  Fly  1446 --VSERCV---NITSV-CDDTPDCPNGSDEG-EGCD---------LAECE------HQAGQCS-- 1486

  Fly   969 ATCEPTEDPANYECQCIAGFK--GDGYVCIEEQNCLNNPTLCDMNAQCRSTNSGLVCVCNQGFF- 1030
            :.|:.|  |....|.|..|.:  .|||.||:...| :.|.||  :.||.:|.....|.|..|:. 
  Fly  1487 SFCQKT--PNGALCVCPPGSEIGEDGYTCIDSNEC-DPPGLC--SQQCTNTKGSYFCSCTDGYVL 1546

  Fly  1031 -GNGSLCQERQHQDSDFLIVS--QGVMIARVPLNGRNVRPISVAQMAIGLDKDCVEGRVYWGDIS 1092
             .|...|:...| .:.|||:|  ..:::|.:...|....|| :.:..:....:...|.::|.|:.
  Fly  1547 EPNKHTCKAVNH-TAAFLIISNRHSILVADLKEQGLERVPI-IVENVVATASNMHTGTIFWSDMK 1609

  Fly  1093 TKKIVSTKYD-GTDLRPFITTDIESPEGIAIDVISRRLYWADSAKDTIEVASLDDPSLRAVIINK 1156
            .|||  ::.| |.:.:..|.|.::..||:|.|.|::.|||.||..:|||| |.::.|.|.|::.:
  Fly  1610 LKKI--SRLDRGMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEV-SAENGSNRLVLVRE 1671

  Fly  1157 QLVNPRGIAVDPY--REKLFWSDWDRESPKIEMSNLDGTGRELLLGKDDVTLPNSLVVLENSGEV 1219
            .:..|||:.:||.  ...:||:||. |:|::|...:|||.|:.:: ...:..||.|.:...:..|
  Fly  1672 NITQPRGMCIDPSPGARWIFWTDWG-ENPRVERIGMDGTMRKTII-NTKIYWPNGLTLDIATKRV 1734

  Fly  1220 CYADAGTKKVECIE------PQNRQIRTISNELSYPFGITFTHDQFYWTDWTTKKVEIVDSL-GA 1277
            .:||:   |::.|:      ...:|:...|:.|.:|..::...|..||||....:|...:.. |.
  Fly  1735 YFADS---KLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKFRGK 1796

  Fly  1278 RQTPIQPPFFGSHKMYGMTVVEQH----CPQYQSPCQISNGGCTDSRLCLVNRQAPSGKSCKCTS 1338
            .||.:      ||.:.....:..|    .|...:||    .|.....|||::..||.|.||||  
  Fly  1797 NQTVV------SHLISQPLSIHVHHASLQPMTPNPC----AGSRCQHLCLLSPSAPEGYSCKC-- 1849

  Fly  1339 ASTGCTVLAPG 1349
             ..|..:|:.|
  Fly  1850 -RPGFKLLSEG 1859

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NdgNP_610575.1 NIDO 108..262 CDD:214712 40/222 (18%)
EGF_3 285..320 CDD:463759 8/41 (20%)
G2F 322..549 CDD:214774 38/252 (15%)
EGF_CA 591..622 CDD:429571 9/49 (18%)
EGF_3 797..828 CDD:463759 9/51 (18%)
EGF_3 836..873 CDD:463759 10/54 (19%)
EGF_3 963..995 CDD:463759 10/33 (30%)
EGF_3 1001..1036 CDD:463759 11/36 (31%)
NHL 1074..>1254 CDD:302697 56/188 (30%)
NHL repeat 1074..1112 CDD:271320 9/38 (24%)
LY 1107..1145 CDD:214531 17/37 (46%)
NHL repeat 1117..1156 CDD:271320 18/38 (47%)
LY 1152..1195 CDD:214531 16/44 (36%)
NHL repeat 1161..1202 CDD:271320 16/42 (38%)
NHL repeat 1210..1244 CDD:271320 7/39 (18%)
mglNP_572563.3 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:469594
YncE <492..634 CDD:442618 22/123 (18%)
NHL 573..>716 CDD:302697 22/144 (15%)
NHL repeat 573..610 CDD:271320 3/36 (8%)
NHL repeat 616..654 CDD:271320 9/39 (23%)
NHL repeat 657..693 CDD:271320 3/35 (9%)
FXa_inhibition 763..805 CDD:464251 10/60 (17%)
YvrE 854..>992 CDD:442613 21/143 (15%)
LY 922..964 CDD:214531 4/42 (10%)
LY 973..1007 CDD:214531 7/38 (18%)
Ldl_recept_a 1188..1223 CDD:395011 10/47 (21%)
LDLa 1227..1259 CDD:197566 11/42 (26%)
LDLa 1268..1303 CDD:238060 11/35 (31%)
LDLa 1308..1343 CDD:238060 7/36 (19%)
LDLa 1356..1387 CDD:238060 5/32 (16%)
LDLa 1391..1423 CDD:197566 10/31 (32%)
LDLa 1435..1469 CDD:197566 13/42 (31%)
FXa_inhibition 1522..1553 CDD:464251 10/32 (31%)
LY 1625..1665 CDD:214531 18/40 (45%)
LY 1667..1711 CDD:214531 16/44 (36%)
Ldl_recept_b 1690..1729 CDD:459654 14/40 (35%)
LY 1712..1754 CDD:214531 8/45 (18%)
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:464251
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:459654
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
FXa_inhibition 3259..3287 CDD:464251
FXa_inhibition 3293..3329 CDD:464251
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
Ldl_recept_b 3468..3511 CDD:459654
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:464251
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4391 CDD:459654
LY 4374..4417 CDD:214531
NHL repeat 4376..4422 CDD:271320
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.