Protein Alignment Ndg and nid1a

DIOPT Version :10

• Sequence 1: NP_610575.1
• Gene: Ndg / 36089
• FlyBaseID: FBgn0026403
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_691156.6
• Gene: nid1a / 562690
• ZFINID: ZDB-GENE-050302-58
• Length: 1175
• Species: Danio rerio
• Alignment Length: 1459
• Identity: 395/1459 - (27%)
• Similarity: 570/1459 - (39%)
• Gaps: 427/1459 - (29%)

  Fly    12 LLLSSVILVSGQFEHYLDSLRASELYEFEDGSLGSIHLLPKGDSETIVLQLEQPIHFYGEQYEQL 76
            :|....:.|||...|        ||:.|  |.......|.:|:.||..:.|::||.|:.||:.::
Zfish    13 ILFGLTLSVSGITRH--------ELFPF--GRNAGDQSLREGNDETQEVNLDKPITFHDEQFSKI 67

  Fly    77 YINTNGILTFNSEFP----EYLNQPFPLEYASIAAFYSNVDTSFSDEGTSISLF-ESKEQSILDR 136
            ||||||.:..  |.|    ||| :..|..:..|||...::|||   :|.....| :....::|.:
Zfish    68 YINTNGFVAL--EKPTGESEYL-ENMPASFKMIAALQGDLDTS---DGVGKVFFRQDLSAALLQQ 126

  Fly   137 ASSLVRYAFSSQSEFEARQVIVATWRNVGYF--DSKTD------RLNTFQVALIANEQSTFVQFI 193
            |:..:..||...........:|.||.:|...  :|:.|      |.||||:.:.:.|.|::...:
Zfish   127 AADHINRAFPEDDLVNPIHALVVTWLDVASHKAESRGDGLEHSIRRNTFQLVIASVETSSYAILL 191

  Fly   194 YPDGGLNWLQGETAGLGLPDIRAQAGFVAEDGRFYTLNGSGSENARFLSESTNLGVPGVWLFE-- 256
            ||...   :|.::.|.|   ....|||......:|........:.:.|.|.||.|..|||::|
Zfish   192 YPRDS---IQFQSTGSG---YTVHAGFSKTQELYYRNTEDTEASVKDLPEQTNSGKRGVWVYEIG 250

  Fly   257 -------VAP---------------IENEQNVRSPD----------------------------- 270
                   :||               .:|:|....||
Zfish   251 TFPHFTNIAPGEVPDLPLDSLRRSETQNQQQQVYPDVQQENLDGVYHHAEHPPPIQVHTVQFTPQ 315

  Fly   271 --------NAESLTESPALALSCQAHAHQCHEKAECHDKAEGYCCVCGSGFYGNGKSCLANDQPI 327
                    |.:::........|.|....:|.:.|||    .|.||||..|:||:|..|:....|.
Zfish   316 DPQVVEIENDDNIQVDVFTYNSGQCGGQKCSKFAEC----SGRCCVCKPGYYGSGVHCVPEGVPQ 376

  Fly   328 RVTGTLTGE--LNKQPVSEE---AKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWL 387
            |:.|.::|.  :...||..:   ..|.||||.::||.|..|:.:.|.:|..|:.:..:...:.|.
Zfish   377 RMNGKVSGRVFVGNSPVPVDFASNDLHSYVVANDGRAYVAISAIPPVIGFSLQPLSSVGGVIGWA 441

  Fly   388 FAKSVGGVANGYQLTGGVYTHVSRLQFD-SGENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAAD 451
            ||....|..||:.:.||.:...:.:.|. .|:.|.::|.|.|::..|.|.|...:.|::|.|...
Zfish   442 FALQQPGFKNGFSIIGGEFKRQADVSFQPGGDKLTISQEFRGIDEHDHLMVDTRLEGKIPEVPQG 506

  Fly   452 AVLILPDYVEEYTFERPGELKSVQVLNINITEEQRVLGL----------QVEQRILYRSCLRDDE 506
            |.:.:..|.|.|.:       |:.::..:.|.|. |:.|          ...:.|.::.|..|:.
Zfish   507 ATVQIDSYSEIYQY-------SINLITSSSTREY-VISLPDGSTQSRSYNFRETITFQGCQFDEV 563

  Fly   507 ADPSATKVLQKISKVALDYVERDQALRIGAMSKVGVT----PESNACNDGTADCVENSVCVPYE- 566
              || |::| .:.:|.:.|....|.||....:|:|..    .|.|||..|...|..|:||.|.:
Zfish   564 --PS-TQML-SVEQVFVMYDMGAQLLRYAMSNKIGDVNGGQSEENACFTGRHGCDTNAVCKPGQG 624

  Fly   567 DTYRCDCYHGFAAQLDERGVEVCLDIDECATGSHVCDENAVCDNTEGGFNCYCTEGFEGNGYRCL 631
            :.:.|:|..||..  |.|   .|.|||||.....:|.:|::|:|..|.|.|.|.:||:
Zfish   625 NQFTCECAAGFTG--DGR---ACYDIDECRETPQICGQNSICNNQPGTFRCECLDGFQ------- 677

  Fly   632 SNSTADNIEYPPAVEGQAEPTSEPSPNPSPYPDQGQDQEREREDDQYPQPNPYPYPEEQIPQHPD 696
                                                                             
Zfish   678 ----------------------------------------------------------------- 677

  Fly   697 ECYRCSKDADCYQGRCTCHEGFDGDGYTCTNICGHGEVWENGRCEPLLLERHDVDPLCDALGECR 761
                                 |..||.||..:                  ...|||       ||
Zfish   678 ---------------------FASDGQTCVEV------------------HRPVDP-------CR 696

  Fly   762 CPYGYELSEDSQRCTYVQEFDGERNADLIPCDVDENCHINATCNWYGQELRHICTCQPGFRGDGY 826
                                .|..:     |||.|    .|.|::.|.. .:||||.|||.|||.
Zfish   697 --------------------SGTHD-----CDVPE----RARCSYTGGS-SYICTCAPGFMGDGR 731

  Fly   827 NCDPISDDSCAIRPDICDVHADCVYEEHLGKSECQCQAGYTGNGFNCQLAAECQSAEHCGENAFC 891
            .|..|  |.|.:..  |..:|.|....  |...|||..|:.|:||.|....|
Zfish   732 RCQDI--DECQVNQ--CHENAVCFNTP--GSFSCQCNPGFHGDGFYCSTERE------------- 777

  Fly   892 DDGVCRCQADFERDV-----SDRCVPAGRCGSVFCGSNAICKWDSAEGVQYCDCLDGYQGDALTG 951
               ..||:...|..|     |.|..| ||.                  |..||....|:
Zfish   778 ---KTRCELHKESVVGFGPHSARPQP-GRF------------------VPTCDAQGRYE------ 814

  Fly   952 CTSKPLSCHVLNNCGIHATCEPTEDPANYECQCIAGFKGDGYVCIEEQNCLNNPTLCDMNAQCRS 1016
                |:.||.  :.|              :|.|:   ..||    ||             .....
Zfish   815 ----PMQCHA--SIG--------------QCWCV---DRDG----EE-------------ISGTR 839

  Fly  1017 TNSGLVCVCNQGFFGNGSLCQERQHQDS-----------------DFLIVSQGVMIARVPLNGRN 1064
            |..|...||             |.|.:|                 ..::.:|...|..:||:|.|
Zfish   840 TGPGRFPVC-------------RGHDESGPIRPTPNPNISPLPPGSHILFTQSGKIEYIPLDGHN 891

  Fly  1065 VRPISV-------AQMAIGLDKDCVEGRVYWGDISTKKIVSTKYDGTDLRPFITTDIESPEGIAI 1122
            ::....       .::.||:..||||..:||.||||..|......|.:....|.:||.|||||||
Zfish   892 LKKNEAKTALHLPEKVVIGIAYDCVEKMIYWTDISTPAISRANLQGGEPVQLIKSDIGSPEGIAI 956

  Fly  1123 DVISRRLYWADSAKDTIEVASLDDPSLRAVIINKQLVNPRGIAVDPYREKLFWSDWDRESPKIEM 1187
            |.:.|.::|.||.||.|||:|||. :.|.|::|..|||||.|..|.....:||:||:||||||||
Zfish   957 DHLGRNMFWTDSMKDRIEVSSLDG-TQRRVLVNTDLVNPRAILTDSTNGYIFWADWNRESPKIEM 1020

  Fly  1188 SNLDGTGRELLLGKDDVTLPNSLVVLENSGEVCYADAGTKKVECIEPQNRQIRTISNELSYPFGI 1252
            :.:|||.|. :|.|||::|||.|.....:..:|:|||||.||||:.||..:...:..|:.||||:
Zfish  1021 AYMDGTNRR-VLAKDDLSLPNGLTYDPQTSLLCWADAGTHKVECMNPQQGRRTQLMEEIQYPFGL 1084

  Fly  1253 TFTHDQFYWTDWTTKKVEIVDSLGARQT-PIQPPFFGSHKMYGMTVVEQHCPQYQSPCQISNGGC 1316
            |.....||:||||...|.:||....|:. ..||.  ...::||:|.....||..|:.|..:||||
Zfish  1085 TTDGKNFYYTDWTRVSVVVVDRHLRREVDEFQPQ--KRTRLYGITTAHARCPAGQNYCSSNNGGC 1147

  Fly  1317 TDSRLCLVNRQAPSGKSCKC--TSASTGC 1343
            |  .|||.   .|:|:||:|  .:|..||
Zfish  1148 T--HLCLA---TPAGRSCRCPDNAAELGC 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndg	NP_610575.1	NIDO	108..262	CDD:214712	42/186 (23%)
		EGF_3	285..320	CDD:463759	14/34 (41%)
		G2F	322..549	CDD:214774	63/246 (26%)
		EGF_CA	591..622	CDD:429571	13/30 (43%)
		EGF_3	797..828	CDD:463759	13/30 (43%)
		EGF_3	836..873	CDD:463759	12/36 (33%)
		EGF_3	963..995	CDD:463759	5/31 (16%)
		EGF_3	1001..1036	CDD:463759	4/34 (12%)
		NHL	1074..>1254	CDD:302697	88/179 (49%)
		NHL repeat	1074..1112	CDD:271320	15/37 (41%)
		LY	1107..1145	CDD:214531	21/37 (57%)
		NHL repeat	1117..1156	CDD:271320	21/38 (55%)
		LY	1152..1195	CDD:214531	24/42 (57%)
		NHL repeat	1161..1202	CDD:271320	21/40 (53%)
		NHL repeat	1210..1244	CDD:271320	13/33 (39%)
nid1a	XP_691156.6	None