DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ndg and NID1

DIOPT Version :10

Sequence 1:NP_610575.1 Gene:Ndg / 36089 FlyBaseID:FBgn0026403 Length:1350 Species:Drosophila melanogaster
Sequence 2:NP_002499.2 Gene:NID1 / 4811 HGNCID:7821 Length:1247 Species:Homo sapiens


Alignment Length:1507 Identity:386/1507 - (25%)
Similarity:566/1507 - (37%) Gaps:455/1507 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LLACLLLSSVILVSGQFEHYLDSLRASELYEFEDGSLGSIHLLPKGDSETIVLQLEQPIHFYG-E 71
            ||..||...|..:|.|           ||:.|..|. |.:.|....|..:..|:|...:.||. .
Human    17 LLPLLLAGPVGCLSRQ-----------ELFPFGPGQ-GDLELEDGDDFVSPALELSGALRFYDRS 69

  Fly    72 QYEQLYINTNGILTFNSEFPEYLNQP--FPLEYASIAAFYSNVDTSFSDEGTSISLFESKEQSIL 134
            ..:.:|:.||||:. .||.|...:.|  ||..:.::|.|.:::||  :|....:...|....||.
Human    70 DIDAVYVTTNGIIA-TSEPPAKESHPGLFPPTFGAVAPFLADLDT--TDGLGKVYYREDLSPSIT 131

  Fly   135 DRASSLVRYAFSSQSEFEARQVIVATWRNVGYF-------DSKTDRLNTFQVALIANEQSTFVQF 192
            .||:..|...|...| |:....:|.||.:|..:       |.|..| ||||..|.:::.|::..|
Human   132 QRAAECVHRGFPEIS-FQPSSAVVVTWESVAPYQGPSRDPDQKGKR-NTFQAVLASSDSSSYAIF 194

  Fly   193 IYPDGGLNW--LQGETAGLGLPDI----RAQAGFVAEDGRFYTLNGSGSENARFLSESTNLGVPG 251
            :||:.||.:  ...:.....:|.:    :...||:.:....|.:..:..|:...|::|:|.|..|
Human   195 LYPEDGLQFHTTFSKKENNQVPAVVAFSQGSVGFLWKSNGAYNIFANDRESVENLAKSSNSGQQG 259

  Fly   252 VWLFEV---------------------APIENEQ------------------------------- 264
            ||:||:                     |..::|.                               
Human   260 VWVFEIGSPATTNGVVPADVILGTEDGAEYDDEDEDYDLATTRLGLEDVGTTPFSYKALRRGGAD 324

  Fly   265 -----NVRSPDNAESLTESP-----------ALAL------------------------------ 283
                 :|.||..|  .||.|           .||:                              
Human   325 TYSVPSVLSPRRA--ATERPLGPPTERTRSFQLAVETFHQQHPQVIDVDEVEETGVVFSYNTDSR 387

  Fly   284 -SCQAHAHQCHEKAECHDKAEGYCCVCGSGFYGNGKSCLANDQPIRVTGTLTGEL----NKQP-V 342
             :|..:.|||...|||.|.|.|:||.|.:|:.|||:.|:|...|.||.|.:.|.:    ::.| |
Human   388 QTCANNRHQCSVHAECRDYATGFCCSCVAGYTGNGRQCVAEGSPQRVNGKVKGRIFVGSSQVPIV 452

  Fly   343 SEEAKLQSYVVTSEGRTYTTINPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANGYQLTGGVYT 407
            .|...|.||||.:.||:||.|:.:...:|..|..:.|:...:.|:||....|..||:.:|||.:|
Human   453 FENTDLHSYVVMNHGRSYTAISTIPETVGYSLLPLAPVGGIIGWMFAVEQDGFKNGFSITGGEFT 517

  Fly   408 HVSRLQF-DSGENLHVNQTFEGLNYWDQLSVKIEIYGEVPAVAADAVLILPDYVEEYTFERPGEL 471
            ..:.:.| ....||.:.|.|.|::....|::..|:.|.||.:...:.:.:..|.|.|.:      
Human   518 RQAEVTFVGHPGNLVIKQRFSGIDEHGHLTIDTELEGRVPQIPFGSSVHIEPYTELYHY------ 576

  Fly   472 KSVQVLNINITEE-------------QRVLGLQVEQRILYRSCLRDDE--ADPSATKVLQKISKV 521
             |..|:..:.|.|             .|:...|..|.|.::.|:.||.  |.||..::  .:..|
Human   577 -STSVITSSSTREYTVTEPERDGASPSRIYTYQWRQTITFQECVHDDSRPALPSTQQL--SVDSV 638

  Fly   522 ALDYVERDQALRIGAMSKVGVTPE------SNACNDGTADCVENSVCVPYEDT-YRCDCYHGFAA 579
            .:.|.:.::.||....:.:|...|      .|.|..||..|..|:.|.|...| :.|:|..||..
Human   639 FVLYNQEEKILRYALSNSIGPVREGSPDALQNPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRG 703

  Fly   580 QLDERGVEVCLDIDECATGSHVCDENAVCDNTEGGFNCYCTEGFEGNGYRCLSNSTADNIEYPPA 644
              |.|   .|.|||||:....||..:.:|:|..|.|.|.|.||::                    
Human   704 --DGR---TCYDIDECSEQPSVCGSHTICNNHPGTFRCECVEGYQ-------------------- 743

  Fly   645 VEGQAEPTSEPSPNPSPYPDQGQDQEREREDDQYPQPNPYPYPEEQIPQHPDECYRCSKDADCYQ 709
                             :.|:|                                           
Human   744 -----------------FSDEG------------------------------------------- 748

  Fly   710 GRCTCHEGFDGDGYTCTNICGHGEVWENGRCEPLLLERHDVDPLCDALGECRCPYGYELSEDSQR 774
                          ||..:.                                         |.:.
Human   749 --------------TCVAVV-----------------------------------------DQRP 758

  Fly   775 CTYVQEFDGERNADLIPCDVDENCHINATCNWYGQELRHICTCQPGFRGDGYNCDPISDDSCAIR 839
            ..|.:  .|..|     ||:.:    .|.|.:.|.. .:.|:|.|||.|||..|..:  |.|  :
Human   759 INYCE--TGLHN-----CDIPQ----RAQCIYTGGS-SYTCSCLPGFSGDGQACQDV--DEC--Q 807

  Fly   840 PDICDVHADCVYEEHLGKSECQCQAGYTGNGFNCQLAAECQSAEHCGENAFCDDGVCRCQADFER 904
            |..|  |.|.......|...|||:.||.|:||.| :..|.:..              |||.:.|.
Human   808 PSRC--HPDAFCYNTPGSFTCQCKPGYQGDGFRC-VPGEVEKT--------------RCQHEREH 855

  Fly   905 DVS-------DRCVPAGRCGSVFCGSNAICKWDSAEGVQYCDCLDGYQGDALTGCTSKPLSCHVL 962
            .:.       .|.:|.|    :|              |..||....|          .|..||  
Human   856 ILGAAGATDPQRPIPPG----LF--------------VPECDAHGHY----------APTQCH-- 890

  Fly   963 NNCGIHATCEPTEDPANYECQCIAGFKGDGYVCIEEQNCLNNPTLCDMNAQCRSTNSGLVCVCNQ 1027
                         ....| |.|:   ..||.   |.:.....|   .|...|.||.:..:     
Human   891 -------------GSTGY-CWCV---DRDGR---EVEGTRTRP---GMTPPCLSTVAPPI----- 927

  Fly  1028 GFFGNGSLCQERQHQ------------DSDFLIVSQGVMIARVPLNGRNVRPISV-------AQM 1073
                         ||            ....|:.:|...|.|:||.|..:|....       |::
Human   928 -------------HQGPAVPTAVIPLPPGTHLLFAQTGKIERLPLEGNTMRKTEAKAFLHVPAKV 979

  Fly  1074 AIGLDKDCVEGRVYWGDISTKKIVSTKYDGTDLRPFITTDIESPEGIAIDVISRRLYWADSAKDT 1138
            .|||..|||:..|||.||:...|......|.:....|..|:.||||||:|.:.|.::|.||..|.
Human   980 IIGLAFDCVDKMVYWTDITEPSIGRASLHGGEPTTIIRQDLGSPEGIAVDHLGRNIFWTDSNLDR 1044

  Fly  1139 IEVASLDDPSLRAVIINKQLVNPRGIAVDPYREKLFWSDWDRESPKIEMSNLDGTGRELLLGKDD 1203
            ||||.||. :.|.|:....|||||||..|..|..|:|:||:|::||||.|.:|||.|.:|: :||
Human  1045 IEVAKLDG-TQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGTNRRILV-QDD 1107

  Fly  1204 VTLPNSLVVLENSGEVCYADAGTKKVECIEPQNRQIRTISNELSYPFGITFTHDQFYWTDWTTKK 1268
            :.|||.|.....|.::|:.||||.:.||:.|.....|.....|.|||.:|......|:|||....
Human  1108 LGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEGLQYPFAVTSYGKNLYFTDWKMNS 1172

  Fly  1269 VEIVDSLGARQTPIQPPFFGSHK---MYGMTVVEQHCPQYQSPCQISNGGCTDSRLCLVNRQAPS 1330
            |..:|...:::|..    |..||   :||:|.....|||..:.|.::|||||  .|||.   .|.
Human  1173 VVALDLAISKETDA----FQPHKQTRLYGITTALSQCPQGHNYCSVNNGGCT--HLCLA---TPG 1228

  Fly  1331 GKSCKCTSASTG 1342
            .::|:|...:.|
Human  1229 SRTCRCPDNTLG 1240

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NdgNP_610575.1 NIDO 108..262 CDD:214712 46/187 (25%)
EGF_3 285..320 CDD:463759 17/34 (50%)
G2F 322..549 CDD:214774 67/253 (26%)
EGF_CA 591..622 CDD:429571 13/30 (43%)
EGF_3 797..828 CDD:463759 11/30 (37%)
EGF_3 836..873 CDD:463759 14/36 (39%)
EGF_3 963..995 CDD:463759 5/31 (16%)
EGF_3 1001..1036 CDD:463759 5/34 (15%)
NHL 1074..>1254 CDD:302697 79/179 (44%)
NHL repeat 1074..1112 CDD:271320 14/37 (38%)
LY 1107..1145 CDD:214531 18/37 (49%)
NHL repeat 1117..1156 CDD:271320 19/38 (50%)
LY 1152..1195 CDD:214531 23/42 (55%)
NHL repeat 1161..1202 CDD:271320 21/40 (53%)
NHL repeat 1210..1244 CDD:271320 11/33 (33%)
NID1NP_002499.2 NIDO 106..269 CDD:214712 45/166 (27%)
EGF_3 390..425 CDD:463759 17/34 (50%)
nidG2 429..660 CDD:238158 64/239 (27%)
EGF_3 672..708 CDD:463759 14/40 (35%)
Cell attachment site 702..704 0/3 (0%)
EGF_CA 710..751 CDD:214542 18/134 (13%)
EGF_3 762..800 CDD:463759 15/49 (31%)
EGF_3 811..839 CDD:463759 12/29 (41%)
Thyroglobulin_1 849..919 CDD:459665 22/122 (18%)
Vgb 934..1177 CDD:443399 94/244 (39%)
LDL-receptor class B 1 990..1032 16/41 (39%)
LY 1014..1055 CDD:214531 20/41 (49%)
LDL-receptor class B 2 1033..1075 21/42 (50%)
LY 1056..1100 CDD:214531 23/43 (53%)
LDL-receptor class B 3 1076..1120 21/44 (48%)
LDL-receptor class B 4 1121..1162 14/40 (35%)
FXa_inhibition 1212..>1236 CDD:464251 12/28 (43%)

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