Protein Alignment Ndg and MUC4

DIOPT Version :10

• Sequence 1: NP_610575.1
• Gene: Ndg / 36089
• FlyBaseID: FBgn0026403
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_001309397.1
• Gene: MUC4 / 4585
• HGNCID: 7514
• Length: 7418
• Species: Homo sapiens
• Alignment Length: 1204
• Identity: 220/1204 - (18%)
• Similarity: 353/1204 - (29%)
• Gaps: 465/1204 - (38%)

  Fly    74 EQLYINTNGILTFNSEFPEYLNQPFPL--------EYASIAAFYSNVDTSFSDEGTSI----SLF 126
            :.||...||.:.|.....:..:.|.||        ..|.:|.|:.:.|.| :..||:.    ..|
Human  6362 DSLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVALVAPFWDDADFS-TGRGTTFYQEYETF 6425

  Fly   127 ESKEQSILDRASSLVRYAFSSQSEFEARQVIVATWRNVGYFDSK-TDRLNTFQVALIANEQSTFV 190
            ..:...::.:|.|.:| ..::...::||..:..||.|...:.:: |...||:|..|..:...::.
Human  6426 YGEHSLLVQQAESWIR-KMTNNGGYKARWALKVTWVNAHAYPAQWTLGSNTYQAILSTDGSRSYA 6489

  Fly   191 QFIYPDGGLNWLQGETAGLGLPDIRAQAGFVAEDGRFYTLNGSGSENARFLSE------------ 243
            .|:|..||:.|...:.:|..:     ..||.:.||.|        ||:..:|:
Human  6490 LFLYQSGGMQWDVAQRSGNPV-----LMGFSSGDGYF--------ENSPLMSQPVWERYRPDRFL 6541

  Fly   244 STNLGVPGVWLFEVAPIENEQNVRSPDNAESLTESPALALSCQAHAHQCHEKAECHDKAEGYCCV 308
            ::|.|:.|:..:.   :..|             |.|...|.|....     |::....:.|:
Human  6542 NSNSGLQGLQFYR---LHRE-------------ERPNYRLECLQWL-----KSQPRWPSWGW--- 6582

  Fly   309 CGSGFYGNGKSCLANDQPIRVTGTLTGELNKQPVSEEAKLQSYVVTSEGRTYTTINPLTPELGAQ 373
                   |..||..:.|..|      .:|..|||            |.||.         .||::
Human  6583 -------NQVSCPCSWQQGR------RDLRFQPV------------SIGRW---------GLGSR 6613

  Fly   374 LRLVLPLLTTVPWLFAKSVGGVANGYQLTGGVYTHVSRLQFDSGENLHVNQTFEGLNYWDQLSVK 438
                 .|.:...|.     |||...|...|           :..|..||.:.      | ||:.:
Human  6614 -----QLCSFTSWR-----GGVCCSYGPWG-----------EFREGWHVQRP------W-QLAQE 6650

  Fly   439 IE-------------------------------------IYGEVPAVAADAVLILPDYVEEYTFE 466
            :|                                     ::|:......|.|        .|||.
Human  6651 LEPQSWCCRWNDKPYLCALYQQRRPHVGCATYRPPQPAWMFGDPHITTLDGV--------SYTFN 6707

  Fly   467 RPGE--LKSVQVLNINITEEQRVL---GLQVEQRILYRSCLRDDEADPSATKVLQKISKVALDYV 526
            ..|:  |...|..|.:...:.|..   ..|....|.:.:..|.....|...:.|          :
Human  6708 GLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQYRSSSLGPVTVQWL----------L 6762

  Fly   527 ERDQALRIGAMSKVGVTPESNACNDGTADCVENSVCVPYEDTYRCDCYHGFAAQLDERGVEVCLD 591
            |...|:|: .:....||.:.:                 :||....:.::.....|...|.||...
Human  6763 EPHDAIRV-LLDNQTVTFQPD-----------------HEDGGGQETFNATGVLLSRNGSEVSAS 6809

  Fly   592 IDECATGSHVCDENAVCDNTEGGFNCYCTEGFEGNGYRCLSNSTADNIEYPPAVEGQAEP----- 651
            .|..||.|.:                            .|||....:...||..:.:.|.
Human  6810 FDGWATVSVI----------------------------ALSNILHASASLPPEYQNRTEGLLGVW 6846

  Fly   652 TSEPS-----PNPSPYPDQGQDQER----------------EREDDQYPQPNPYPYPEEQIPQHP 695
            .:.|.     ||.|..| .|..:|.                .:.:||.|. |..|....|:.::.
Human  6847 NNNPEDDFRMPNGSTIP-PGSPEEMLFHFGMTWQINGTGLLGKRNDQLPS-NFTPVFYSQLQKNS 6909

  Fly   696 DEC----YRCSKDADC---------------------------------------------YQGR 711
            ...    ..|..|:.|                                             |:|:
Human  6910 SWAEHLISNCDGDSSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSINGGRVIEAYKGQ 6974

  Fly   712 CTCHE---GFDGDGYTCTNICGHGEVWENG-------RCEPLLLE----------RHDVDP---L 753
            .|..:   ..:...:|..:.|...|::|||       ..||..||          ...:.|   :
Human  6975 TTLIQYTSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILARSAKIGLASALQPRTVV 7039

  Fly   754 CDALGECRCPYGY-------ELSEDSQRC---TYVQEFDGERNADLIPCDVDENCHINATCNWYG 808
            |....|.:|.|..       .|.....:|   |:.:..:|..:|...||....:|.....|.
Human  7040 CHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVPGKGCE--- 7101

  Fly   809 QELRHICTCQPGFRGDGYNCDPI------SDDSCAIRPDICDVHADCVYEEHLG-KSECQCQAGY 866
                   .|.|...|||.:|..:      .:.||.:  :.|.....|...:.|| :..|.|...:
Human  7102 -------ACPPNLTGDGRHCAALGSSFLCQNQSCPV--NYCYNQGHCYISQTLGCQPMCTCPPAF 7157

  Fly   867 T-------GNGFNCQLAAECQ--------SAEHCGENAFCDDGVCRCQADFERDVSDRCVPAGRC 916
            |       ||.|:..:..|..        |.|   |||        ..|:....|      |.|.
Human  7158 TDSRCFLAGNNFSPTVNLELPLRVIQLLLSEE---ENA--------SMAEVNASV------AYRL 7205

  Fly   917 GSV----FCGSNAICKWDSA-----EGVQYCDCLDGYQ----GDALTGCTSKPLSCHVLNNCGIH 968
            |::    |..::.:.:.|||     ..:|:...:..:|    |..:          ..|||..:.
Human  7206 GTLDMRAFLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVI----------DFLNNQLLA 7260

  Fly   969 ATCEP--------TEDPAN--------------------------YECQCIAGFKG--------D 991
            |..|.        :|:|.|                          :.|.   |:||        .
Human  7261 AVVEAFLYHVPRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCD---GYKGYDLVYSPQS 7322

  Fly   992 GYVCIEEQNCLNNPTLCDMNAQCRSTNSGLVCVC 1025
            |:.|:..  |...  .||...||:...||..|.|
Human  7323 GFTCVSP--CSRG--YCDHGGQCQHLPSGPRCSC 7352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndg	NP_610575.1	NIDO	108..262	CDD:214712	36/170 (21%)
		EGF_3	285..320	CDD:463759	4/34 (12%)
		G2F	322..549	CDD:214774	46/268 (17%)
		EGF_CA	591..622	CDD:429571	4/30 (13%)
		EGF_3	797..828	CDD:463759	7/30 (23%)
		EGF_3	836..873	CDD:463759	11/44 (25%)
		EGF_3	963..995	CDD:463759	12/73 (16%)
		EGF_3	1001..1036	CDD:463759	9/25 (36%)
		NHL	1074..>1254	CDD:302697
		NHL repeat	1074..1112	CDD:271320
		LY	1107..1145	CDD:214531
		NHL repeat	1117..1156	CDD:271320
		LY	1152..1195	CDD:214531
		NHL repeat	1161..1202	CDD:271320
		NHL repeat	1210..1244	CDD:271320
MUC4	NP_001309397.1	FhaB	139..1812	CDD:442443
		FhaB	1400..3060	CDD:442443
		FhaB	2936..4579	CDD:442443
		FhaB	4472..6142	CDD:442443
		motB	<6121..6234	CDD:183756
		NIDO	6403..6560	CDD:214712	37/187 (20%)
		AMOP	6559..6674	CDD:128962	34/184 (18%)
		VWD	6679..6859	CDD:214566	39/243 (16%)