Protein Alignment Ndg and Muc4

DIOPT Version :10

• Sequence 1: NP_610575.1
• Gene: Ndg / 36089
• FlyBaseID: FBgn0026403
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_063126583.1
• Gene: Muc4 / 303887
• RGDID: 621331
• Length: 3363
• Species: Rattus norvegicus
• Alignment Length: 1212
• Identity: 229/1212 - (18%)
• Similarity: 381/1212 - (31%)
• Gaps: 408/1212 - (33%)

  Fly    47 IHLLPKGDSETI---------------VLQLEQPIHFYGEQYEQLYINTNGILTFNSEFPEYLNQ 96
            |.|.|.|.|..:               :.:::..........:..|...||.:.|.....:..:.
  Rat  2266 ISLFPYGSSSEVRDKQLFARTVDFTSPIFKIQIGFPLGSSLRDSFYFTDNGQIIFPESDYDVFSY 2330

  Fly    97 PFPLE--------YASIAAFYSNVDTSFSDEGT-----SISLFESKEQSILDRASSLVRYAFSSQ 148
            |.|.:        .|.:|.|:.:.|.| |..||     .|:.::.:.| ::.:..||:. .|:|.
  Rat  2331 PNPPQRGFTGRERVAIVAPFWGDADFS-SSRGTIFYQDYITFYDEQHQ-LIRKVESLIN-EFTSD 2392

  Fly   149 SEFEARQVIVATWRNV------GYFDSKTDRLNTFQVALIANEQSTFVQFIYPDGGLNWLQGETA 207
            ..|:|:..:..||.||      |.|.:     ||:|..|..:...::..|:|..||:.|  ..|.
  Rat  2393 WSFKAKWTLKVTWVNVPAYPAQGSFGT-----NTYQAILSTDGSRSYALFLYQSGGMRW--DVTQ 2450

  Fly   208 GLGLPDIRAQAGFVAEDGRFYTLNGSGSENA--------------RFLSESTNLGVPGVWLF--- 255
            ||   ..|...||.:.||.|        ||:              |||  ::.||:.|:.::
  Rat  2451 GL---YNRVLMGFSSGDGYF--------ENSPLIFRPAVEKYRPDRFL--NSKLGIRGLQVYRLH 2502

  Fly   256 -EVAPIENEQNVRSPDNAESLTESPALA---LSCQAHAHQ-------------------CHEKAE 297
             ||.|   ...::.....||..:.|:..   :||.....|                   |
  Rat  2503 REVWP---NYRLKCLQWLESQPQQPSWGWNKISCPCSWQQGRWDFRFWLINTGLWGRQLC----- 2559

  Fly   298 CHDKAEGYCCVCGSGFYGNGKSCLANDQPIRVTGTLTGELNKQPVSEEAKLQSYVVTSEGRTYTT 362
            ......|..| |..|.:|..:.......|.:             ..||.:.|::......:
  Rat  2560 SFSSGRGGVC-CSYGTWGEFREGWRMHSPWQ-------------FDEEQEAQNWCCRWNDK---- 2606

  Fly   363 INPLTPELGAQLRLVLPLLTTVPWLFAKSVGGVANGYQLTGGVYT----HVSRLQFDSGENLHVN 423
                 |....|.:|..|.::..             ||:.....:|    |::.|.       :..
  Rat  2607 -----PSFCVQYQLRRPRVSCA-------------GYRPPRPAWTFGDPHITTLD-------NAK 2646

  Fly   424 QTFEGLNYWDQLSVKIE-------IYGEVPAV-AADAVLILPDYVEEYTFERPGELKSVQVLNIN 480
            .||.||.  |.|.|:.:       :.|..... :|:|...:. :..:|   ....|||...:...
  Rat  2647 YTFNGLG--DFLLVQAQDRNSSFLLEGRTAQTDSANATNFIA-FAAQY---NTSSLKSPITVQWF 2705

  Fly   481 ITEEQRVLGLQVEQRILYRSCLRDDEADPSATKVL--QKISKVALDYVERDQALRIGAMSKVGVT 543
            :.....:..:...|.:.:.:...:|....:||.||  |..|:|:.::   |..:.|..::...:.
  Rat  2706 LEPNDTIRVVHNNQTVAFNTSDTEDLPVFNATGVLLIQNGSQVSANF---DGTVTISVIALSNIL 2767

  Fly   544 PESNAC---------------NDGTAD--CVENSVCVPYEDTYRCDCYHGFAAQLDERGVEVCLD 591
            ..|::.               ||...|  .:.|...:|...:.....::|...|::..|:   |.
  Rat  2768 HASSSLSEEYRNHTKGLLGVWNDNPEDDFRMPNGSTIPSNSSEETLFHYGMTWQINGTGL---LG 2829

  Fly   592 I------------------DECATGSHV---CDENAVCDNTEGGFNCYCTEGFEGNGYRCLSNST 635
            :                  ::...|..:   |:|:|.|.     |:...|      |.|.:..||
  Rat  2830 VRTDPLPSEFTPIFLSQLWNKSGAGEDLISGCNEDAQCK-----FDILAT------GNRDIGQST 2883

  Fly   636 ADNIEYPPAVEGQAEPTSEPSPNPSPYPDQGQDQEREREDDQYPQPNPYPYPEEQIPQHPDECYR 700
            ...:.....|.|..                          :|||.|..|
  Rat  2884 NSILRTFRHVNGTL--------------------------NQYPPPIHY---------------- 2906

  Fly   701 CSKDADCYQGRCTCHEGFDGDG---YTCTNICGHGEVWENG----------RCEPLLLERHDVDP 752
             |.....|:||....|......   ::.:|.|...|::|||          .|...:|.|.....
  Rat  2907 -SSKIQAYKGRTVAIEITSNSKDVVFSLSNKCSGFELFENGSLQWTPTSPEACTLEILARDVKTN 2970

  Fly   753 LCDALG----ECRCPYGYELSEDSQRCTYVQ-EFDGERNADLIPCDVDENCHINATCNWYGQELR 812
            |...|.    .|.|      |::.| |.|.: ..:|..:.::..|..|.|.        :|:...
  Rat  2971 LSSVLQPETVACFC------SKEEQ-CLYNETSKEGNSSTEVTSCKCDGNS--------FGRLCE 3020

  Fly   813 H---ICT-----------------CQPGFRGDGYNCDPI------SDDSCAIRPDICDVHADCVY 851
            |   :||                 |.|...|||.:|..:      .:.||.:  :.|..|..|
  Rat  3021 HSKDLCTEPCFPNVDCIPGKGCQACPPNMTGDGRHCVAVEISEFCQNHSCPV--NYCYNHGHC-- 3081

  Fly   852 EEHLGKSECQ----CQAGYTGNGFNCQLAA---------------------ECQSAEHCGENAFC 891
             :..|..:||    |...:|||  .|.||.                     |.::|.:...||
  Rat  3082 -DISGPPDCQPTCTCAPAFTGN--RCFLAGNNFTPIIYKELPLRTITLSLREDENASNADVNA-- 3141

  Fly   892 DDGVCRC--QADFERDVSDRCVPAGRCGSVFCGSNAICK----WDSAEGVQYCDCLDGYQGDALT 950
              .|...  ..|....:|:..|...|...   |:.::.|    |......:|
  Rat  3142 --SVANVLENLDMRAFLSNSLVELIRTSP---GAQSLGKPIHHWKVVSHFKY------------- 3188

  Fly   951 GCTSKPLS--CHVLNNCGIHATCEPTEDPANYECQCIAG-------FKGDGYVCIEEQNCLNNPT 1006
                :|..  .|.|||..|.|..|.....|..|.:..:|       |.......:::...| |.:
  Rat  3189 ----RPRGPLIHYLNNQLISAVMEAFLLQARQERRKRSGEARKNVRFFPISRADVQDGMAL-NLS 3248

  Fly  1007 LCDMNAQC---------RSTNSGLVCV--CNQGFFGNGSLCQ 1037
            :.|....|         .|...|:.||  |::|:..||..|:
  Rat  3249 MLDEYFTCDGYKGYHLVYSPQDGVTCVSPCSEGYCHNGGQCK 3290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndg	NP_610575.1	NIDO	108..262	CDD:214712	49/182 (27%)
		EGF_3	285..320	CDD:463759	8/53 (15%)
		G2F	322..549	CDD:214774	39/240 (16%)
		EGF_CA	591..622	CDD:429571	7/51 (14%)
		EGF_3	797..828	CDD:463759	10/50 (20%)
		EGF_3	836..873	CDD:463759	11/40 (28%)
		EGF_3	963..995	CDD:463759	9/38 (24%)
		EGF_3	1001..1036	CDD:463759	12/45 (27%)
		NHL	1074..>1254	CDD:302697
		NHL repeat	1074..1112	CDD:271320
		LY	1107..1145	CDD:214531
		NHL repeat	1117..1156	CDD:271320
		LY	1152..1195	CDD:214531
		NHL repeat	1161..1202	CDD:271320
		NHL repeat	1210..1244	CDD:271320
Muc4	XP_063126583.1	None