DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ndg and Ldlr

DIOPT Version :10

Sequence 1:NP_610575.1 Gene:Ndg / 36089 FlyBaseID:FBgn0026403 Length:1350 Species:Drosophila melanogaster
Sequence 2:NP_034830.2 Gene:Ldlr / 16835 MGIID:96765 Length:862 Species:Mus musculus


Alignment Length:786 Identity:184/786 - (23%)
Similarity:276/786 - (35%) Gaps:256/786 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   696 DECYRCSKDADCYQGRC-----------TCHEGFDGDGYTCTNI--------CGHGEVWENGRCE 741
            |.|.|  .:..|..|:|           .|.:|.|....||.::        || |.|   .||.
Mouse    25 DSCSR--NEFQCRDGKCIASKWVCDGSPECPDGSDESPETCMSVTCQSNQFSCG-GRV---SRCI 83

  Fly   742 PLLLERHDVDP-LCDALGECR-------CPYGYELSEDSQRCTYVQEFDGERNADLIPCDVDENC 798
            |        |. .||...:|.       || ....|:|..||.     ||:..:....||.|.:|
Mouse    84 P--------DSWRCDGQVDCENDSDEQGCP-PKTCSQDDFRCQ-----DGKCISPQFVCDGDRDC 134

  Fly   799 -------HINATCNWYGQELRHICTCQPGFRGDGYNCDPISDDSCAIRPDI--CDVHADCV---- 850
                   |..||            ||.|..    :.|     :|....|.:  ||...|||    
Mouse   135 LDGSDEAHCQAT------------TCGPAH----FRC-----NSSICIPSLWACDGDVDCVDGSD 178

  Fly   851 ----------------------YEEHLGKSECQCQAGYTGNGFNCQLAAECQ---SAEHCG---- 886
                                  .|.|.|.|||      ....:.|...|:|:   ..|||.    
Mouse   179 EWPQNCQGRDTASKGVSSPCSSLEFHCGSSEC------IHRSWVCDGEADCKDKSDEEHCAVATC 237

  Fly   887 --ENAFCDDGVC-----RCQADFE-RDVSDR--CV-------------PAGRCGSV--FCGSNAI 926
              :...|.||.|     :|..:.: :|:||.  ||             .:|.|.|:  .|.|...
Mouse   238 RPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCVNVTQCDGPNKFKCHSGECISLDKVCDSARD 302

  Fly   927 CKWDSAEGVQYC---DCLDGYQGDALTGCTSKPLSCHVLNNCGIHATCEPTEDPANYECQCIAGF 988
            |:..|.|.::.|   :|||                    ||.|....|:..:  ...||.|.:||
Mouse   303 CQDWSDEPIKECKTNECLD--------------------NNGGCSHICKDLK--IGSECLCPSGF 345

  Fly   989 K-GDGYVCIEEQNCLNNPTLCDMNAQCRSTNSGLVCVCNQGFFGNGSLCQERQHQDSDFLIV--- 1049
            : .|.:.|.:...| ..|..|  :..|.:......|.|..||           |.|....:.   
Mouse   346 RLVDLHRCEDIDEC-QEPDTC--SQLCVNLEGSYKCECQAGF-----------HMDPHTRVCKAV 396

  Fly  1050 -SQGVMIARVPLNGRNVRPISV-----------AQMAIGLDKDCVEGRVYWGDISTKKIVSTKYD 1102
             |.|.::.   .|...||.:::           .:..:.||.:....|:||.|:|.|||.|...|
Mouse   397 GSIGYLLF---TNRHEVRKMTLDRSEYTSLLPNLKNVVALDTEVTNNRIYWSDLSQKKIYSALMD 458

  Fly  1103 ---GTDLRPFITTDIESPEGIAIDVISRRLYWADSAKDTIEVASLDDPSLRAVIINKQLVNPRGI 1164
               .......|:.|:.:|:|:|:|.|.|.:||.||...::.||...... |..:..:....||.|
Mouse   459 QAPNLSYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVK-RRTLFQEAGSRPRAI 522

  Fly  1165 AVDPYREKLFWSDWDRESPKIEMSNLDGTGRELLLGKDDVTLPNSLVVLENSGEVCYADAGTKKV 1229
            .|||....::|:||...: ||:...|:|.....|: .:::..||.:.:..:||.:.:.|:....:
Mouse   523 VVDPVHGFMYWTDWGTPA-KIKKGGLNGVDIHSLV-TENIQWPNGITLDLSSGRLYWVDSKLHSI 585

  Fly  1230 ECIEPQNRQIRTI---SNELSYPFGITFTHDQFYWTDWTTKKVEIVDSLGARQTPIQPPFFGSHK 1291
            ..|:......:||   .|.|::||.:....|:.||||                 .|....|.:::
Mouse   586 SSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTD-----------------VINEAIFSANR 633

  Fly  1292 MYGMTV------------------VEQHCPQYQSPCQ----ISNGGCTDSRLCL----VNRQAPS 1330
            :.|..|                  |.|  |:..:.|:    :.||||  ..|||    :...:|.
Mouse   634 LTGSDVNLVAENLLSPEDIVLFHKVTQ--PRGVNWCETTALLPNGGC--QYLCLPAPQIGPHSPK 694

  Fly  1331 GKSCKC 1336
             .:|.|
Mouse   695 -FTCAC 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NdgNP_610575.1 NIDO 108..262 CDD:214712
EGF_3 285..320 CDD:463759
G2F 322..549 CDD:214774
EGF_CA 591..622 CDD:429571
EGF_3 797..828 CDD:463759 7/37 (19%)
EGF_3 836..873 CDD:463759 12/64 (19%)
EGF_3 963..995 CDD:463759 10/32 (31%)
EGF_3 1001..1036 CDD:463759 8/34 (24%)
NHL 1074..>1254 CDD:302697 53/185 (29%)
NHL repeat 1074..1112 CDD:271320 13/40 (33%)
LY 1107..1145 CDD:214531 14/37 (38%)
NHL repeat 1117..1156 CDD:271320 13/38 (34%)
LY 1152..1195 CDD:214531 13/42 (31%)
NHL repeat 1161..1202 CDD:271320 14/40 (35%)
NHL repeat 1210..1244 CDD:271320 6/36 (17%)
LdlrNP_034830.2 Ldl_recept_a 25..58 CDD:395011 8/34 (24%)
Ldl_recept_a 66..104 CDD:395011 11/49 (22%)
Ldl_recept_a 107..143 CDD:395011 10/40 (25%)
Ldl_recept_a 146..184 CDD:395011 12/58 (21%)
Ldl_recept_a 196..232 CDD:395011 10/41 (24%)
Ldl_recept_a 236..271 CDD:395011 8/34 (24%)
Ldl_recept_a 279..309 CDD:395011 7/29 (24%)
FXa_inhibition 319..>347 CDD:464251 12/49 (24%)
EGF_CA 355..389 CDD:214542 10/47 (21%)
LDL-receptor class B 1 398..439 7/43 (16%)
LY 420..458 CDD:214531 11/37 (30%)
LDL-receptor class B 2 440..485 16/44 (36%)
Ldl_recept_b 440..483 CDD:459654 15/42 (36%)
LDL-receptor class B 3 486..528 14/42 (33%)
Ldl_recept_b 486..526 CDD:459654 12/40 (30%)
LDL-receptor class B 4 529..572 10/44 (23%)
Ldl_recept_b 529..569 CDD:459654 10/41 (24%)
LY 553..595 CDD:214531 7/42 (17%)
LDL-receptor class B 5 573..615 9/41 (22%)
LDL-receptor class B 6 616..658 9/58 (16%)
Ldl_recept_b 616..656 CDD:459654 9/56 (16%)
FXa_inhibition 675..712 CDD:464251 10/28 (36%)
Clustered O-linked oligosaccharides 722..770
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 730..761
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130 813..862
NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130 825..830
Blue background indicates that the domain is not in the aligned region.

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