DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ndg and Fbn2

DIOPT Version :10

Sequence 1:NP_610575.1 Gene:Ndg / 36089 FlyBaseID:FBgn0026403 Length:1350 Species:Drosophila melanogaster
Sequence 2:NP_034311.2 Gene:Fbn2 / 14119 MGIID:95490 Length:2907 Species:Mus musculus


Alignment Length:1074 Identity:213/1074 - (19%)
Similarity:308/1074 - (28%) Gaps:461/1074 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   259 PIENEQNVRSPDNAESLTESPALALSCQAHA--------HQCHEKAECHDKA----EGYC----- 306
            |..|...|.:|.           :..|:.||        ..|.:..||....    .|.|     
Mouse   536 PCSNGDCVNTPG-----------SYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDG 589

  Fly   307 ---CVCGSGF--YGNGKSCLANDQPIRVTGTLTGELNKQPVSEEAKLQ-----SYVVTSEGRTYT 361
               |:|.:||  ..:||:|:.:|:    ..|....||...::|:...:     .:::...||..|
Mouse   590 SFQCICNAGFELTTDGKNCVDHDE----CTTTNMCLNGMCINEDGSFKCVCKPGFILAPNGRYCT 650

  Fly   362 TINPL-TPELGAQLRLVLPLLTTVPWLFAKSVGGVANGYQLTG----------GVYTHV-SRLQF 414
            .::.. ||                        |...||:.:..          |:...| .|:..
Mouse   651 DVDECQTP------------------------GICMNGHCINNEGSFRCDCPPGLAVGVDGRVCV 691

  Fly   415 DSGENLHVNQTFEGLNYWDQLSVKIEIYGEV-----------PAVAADAVLILPDYVEEYTFERP 468
            |:    |:..|               .|||:           ....::.....||    |.|..|
Mouse   692 DT----HMRST---------------CYGEIKKGVCVRPFPGAVTKSECCCANPD----YGFGEP 733

  Fly   469 ---------GELKSVQVLNINITEEQRVLGLQVEQRILYRSCLRDDEADPSATKVLQKISKVALD 524
                     .|...:....|.||.:.|                              .|::.|||
Mouse   734 CQPCPAKNSAEFHGLCSSGIGITVDGR------------------------------DINECALD 768

  Fly   525 YVERDQALRIGAMSKVGVTPESNACNDGTADCVENSVCVPYEDTYRCDCYHGFAAQLDERGVEVC 589
                                         .|...|.:|.....:|||:|..|:......|.   |
Mouse   769 -----------------------------PDICANGICENLRGSYRCNCNSGYEPDASGRN---C 801

  Fly   590 LDIDECATGSHVCDENAVCDNTEGGFNCYCTEGFEGNGYRCLSNSTAD--NIEYPPAVEGQAEPT 652
            :|||||.....:|| |.:|.||.|.::|.|..|:.   :|..:.:..|  ..|..|.|.|.....
Mouse   802 IDIDECLVNRLLCD-NGLCRNTPGSYSCTCPPGYV---FRTETETCEDVNECESNPCVNGACRNN 862

  Fly   653 -----SEPSPNPSPYPDQG---------------QDQEREREDD--------------QYPQPNP 683
                 .|.||. |.....|               ||...|...:              .:..|  
Mouse   863 LGSFHCECSPG-SKLSSTGLICIDSLKGTCWLNIQDNRCEVNINGATLKSECCATLGAAWGSP-- 924

  Fly   684 YPYPEEQIPQHPDECYRCSKDADCYQG----------------------------------RCTC 714
                          |.||..||.|.:|                                  .|.|
Mouse   925 --------------CERCELDAACPRGFARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCEC 975

  Fly   715 HEG--FDGDGYTCTNI----------------------------CGHGEVWENGRCE-------- 741
            .||  .||.|..|.:|                            |..|..| ...||        
Mouse   976 PEGLTLDGTGRVCLDIRMEHCFLKWDEDECIHPVPGKFRMDACCCAVGAAW-GTECEECPKPGTK 1039

  Fly   742 ---------PLLLERHDV----------------DPLC------DALG--ECRCPYGYELSEDSQ 773
                     |....|.|:                ..:|      :.:|  :|||..|:.|..:.:
Mouse  1040 EYETLCPRGPGFANRGDILTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNNGFALDMEER 1104

  Fly   774 RCTYVQE------------------------FDG-----------------ERN----------- 786
            .||.:.|                        |:|                 |||           
Mouse  1105 NCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVN 1169

  Fly   787 ----------------------ADLIPCDVDENCHINATC-NWYGQELRHICTCQPGFRG--DGY 826
                                  .|:..|.:.:|...|..| |..|   .:.|:|.||::.  |..
Mouse  1170 TEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVNMIG---TYQCSCNPGYQATPDRQ 1231

  Fly   827 NCDPISDDSCAIRPDICDVHADCVYEEHLGKSECQCQAGYT--GNGFNCQLAAECQSAEHCGENA 889
            .|..|  |.|.|....||  ..|...|  |..||.|..||.  .:|.:|....||::     ...
Mouse  1232 GCTDI--DECMIMNGGCD--TQCTNSE--GSYECSCSEGYALMPDGRSCADIDECEN-----NPD 1285

  Fly   890 FCDDGVCR---------CQADFERDVSDR-CVPAGRCGSVFCGSNAICKW---DSAEGVQYCDCL 941
            .||.|.|.         |...|...:..: |:....|..    :..||.:   ::.:|...|.|.
Mouse  1286 ICDGGQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDL----NPNICMFGECENTKGSFICHCQ 1346

  Fly   942 DGYQ-GDALTGCTSKPLSCHV-LNNCGIHATCEPTEDPANYECQCIAGFKGDGYVCIEEQNCLNN 1004
            .||. ....||||... .|.: .:||.:||:|  ...|.:::|.|..|:.|:|..||:...|.|.
Mouse  1347 LGYSVKKGTTGCTDVD-ECEIGAHNCDMHASC--LNVPGSFKCSCREGWVGNGIKCIDLDECANG 1408

  Fly  1005 PTLCDMNAQCRSTNSGLVCVCNQGFFGNGSLCQE 1038
            ...|.:||||.:|.....|.|::||.|:|..|.:
Mouse  1409 THQCSINAQCVNTPGSYRCACSEGFTGDGFTCSD 1442

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NdgNP_610575.1 NIDO 108..262 CDD:214712 1/2 (50%)
EGF_3 285..320 CDD:463759 14/56 (25%)
G2F 322..549 CDD:214774 36/263 (14%)
EGF_CA 591..622 CDD:429571 14/30 (47%)
EGF_3 797..828 CDD:463759 10/33 (30%)
EGF_3 836..873 CDD:463759 13/38 (34%)
EGF_3 963..995 CDD:463759 11/31 (35%)
EGF_3 1001..1036 CDD:463759 14/34 (41%)
NHL 1074..>1254 CDD:302697
NHL repeat 1074..1112 CDD:271320
LY 1107..1145 CDD:214531
NHL repeat 1117..1156 CDD:271320
LY 1152..1195 CDD:214531
NHL repeat 1161..1202 CDD:271320
NHL repeat 1210..1244 CDD:271320
Fbn2NP_034311.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..58
Fibrillin_U_N 76..112 CDD:436338
Interaction with MFAP4. /evidence=ECO:0000250|UniProtKB:P35556 149..359
TB 224..>257 CDD:459903
EGF_CA 276..>306 CDD:214542
TB 373..417 CDD:459903
EGF_CA 528..558 CDD:214542 7/32 (22%)
EGF_CA 568..609 CDD:214542 10/40 (25%)
EGF_CA 610..650 CDD:214542 7/43 (16%)
EGF_CA 651..691 CDD:214542 8/63 (13%)
TB 706..749 CDD:459903 6/46 (13%)
EGF_CA 761..802 CDD:214542 13/72 (18%)
EGF_CA 803..838 CDD:238011 15/38 (39%)
TB 898..>928 CDD:459903 3/45 (7%)
EGF_CA 948..978 CDD:429571 2/29 (7%)
TB 1003..1045 CDD:459903 5/42 (12%)
EGF_CA 1108..1142 CDD:214542 3/33 (9%)
EGF_CA 1151..1183 CDD:214542 3/31 (10%)
EGF_CA 1193..1225 CDD:214542 11/34 (32%)
FXa_inhibition 1239..1274 CDD:464251 13/38 (34%)
EGF_3 1364..1399 CDD:463759 12/36 (33%)
EGF_3 1405..1440 CDD:463759 14/34 (41%)
EGF_CA 1484..1519 CDD:214542
EGF_CA 1525..1556 CDD:214542
TB 1586..1626 CDD:459903
EGF_CA 1643..1675 CDD:214542
Interaction with MFAP4. /evidence=ECO:0000250|UniProtKB:P35556 1728..2164
TB 1741..1784 CDD:459903
EGF_CA 1801..1833 CDD:214542
EGF_CA 1843..>1875 CDD:214542
vWFA <1880..1922 CDD:469594
EGF_CA 1927..1961 CDD:214542
EGF_CA 1966..2008 CDD:214542
EGF_CA 2009..2041 CDD:214542
EGF_CA 2049..2089 CDD:214542
TB 2104..2148 CDD:459903
EGF_CA 2164..2205 CDD:214542
EGF_CA 2206..2245 CDD:214542
EGF_CA 2287..2319 CDD:429571
TB 2387..2430 CDD:459903
EGF_CA 2442..2475 CDD:214542
FXa_inhibition 2488..2523 CDD:464251
EGF_CA 2525..2554 CDD:429571
EGF_CA 2564..2606 CDD:214542
EGF_CA 2607..>2636 CDD:214542
Cadherin_repeat <2821..>2868 CDD:206637
Blue background indicates that the domain is not in the aligned region.

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