Protein Alignment RNaseZ and Elac2

DIOPT Version :10

• Sequence 1: NP_724916.1
• Gene: RNaseZ / 36086
• FlyBaseID: FBgn0028426
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: XP_006534128.1
• Gene: Elac2 / 68626
• MGIID: 1890496
• Length: 836
• Species: Mus musculus
• Alignment Length: 852
• Identity: 288/852 - (33%)
• Similarity: 434/852 - (50%)
• Gaps: 141/852 - (16%)

  Fly     1 MYLVKSARSPIYRTLRTLTTSNLMAATIASAKDPL--TGPRYEREPNVLRKKLASVVPG---TVN 60
            |:.::|...|:  .|||::..:  |.....:||||  ...|.:|.|.          ||   ||.
Mouse     1 MWALRSLLRPL--GLRTMSQGS--ARRPRPSKDPLRHLRTREKRGPG----------PGGPNTVY 51

  Fly    61 LQVLGSGANGAPAAVYLFTDQARYLFNCGEGTQRLAHEHKTRLSRLEQIFLTQNTWASCGGLPGL 125
            |||:.:|...|.||:|:|::..|||||||||.|||..|||.:::||:.||||:..|::.|||.|:
Mouse    52 LQVVAAGGRDAGAALYVFSEYNRYLFNCGEGVQRLMQEHKLKVARLDNIFLTRMHWSNVGGLCGM 116

  Fly   126 TLTIQDAGVRDIGLHGPPHLGSMLQSMRRFV-VLKNLQ--VRPNDCSEGACFEDSILKVDSLPLI 187
            .||:::.|:....|.|||.|...|::::.|. .||.::  |||:...|   ::|..:.|..:| |
Mouse   117 ILTLKETGLPKCVLSGPPQLEKYLEAIKIFSGPLKGIELAVRPHSAPE---YKDETMTVYQVP-I 177

  Fly   188 NSE------DPTKS--------------------------------------------VINYICQ 202
            :||      .|::|                                            |:.::|:
Mouse   178 HSERRCGKQQPSQSPRTSPNRLSPKQSSDSGSAENGQCPPEDSSAGANRKAWGRDPSLVVAFVCK 242

  Fly   203 LKPRAGALNLVKCVEQGVPPG-----PLLGQLKNGNDITLPDGKVVRSVDVTEASETALSFVFLD 262
            |..|.|...::|..|.|:|.|     |::..:|:|..||. :|:.:.:.::....:..|.|:.::
Mouse   243 LHLRKGNFLVLKAKELGLPVGTAAIAPIIAAVKDGKSITY-EGREIAAEELCTPPDPGLVFIVVE 306

  Fly   263 VPSENY-LPALLTHGKRLKKLGEEKLTEVALVVHFTPYHISSRQVYKDFVVESFSSEAQHIYLSS 326
            .|.|.: ||  :......|:...|....||||||..|..:.....|:.: :|.|..:.||:.|:.
Mouse   307 CPDEGFILP--ICENDTFKRYQAEADAPVALVVHIAPESVLIDSRYQQW-MERFGPDTQHLILNE 368

  Fly   327 PLNQFSGYAAAHRIQHQLHQLAPQVFPLLGEQLSC-QSQTLSLNLKKTKLDEADSEDKANAKANE 390
            ....... ..:|:||.||..:.|.:||.|....|. :..|||:...:.:
Mouse   369 NCPSVHN-LRSHKIQTQLSLIHPDIFPQLTSFYSKEEGSTLSVPTVRGE---------------- 416

  Fly   391 TEEQGVVAMTNYHLRPRKGLDRTLESKLTPEEYVKETHAVPGFLELLAKFK---EEYSFPDNSAD 452
                   .:..|.|||::...|........:|::.|...:|.|.|.:.:::   :|...|.....
Mouse   417 -------CLLKYQLRPKREWQRDTTLDCNTDEFIAEALELPSFQESVEEYRKNVQENPAPAEKRS 474

  Fly   453 SYPKIIFLGTGSCIPNKTRNVSSILIRTAIDAYVLLDCGEGTYGQIVRLYGHEKGQLILRQLQAI 517
            .||:|:||||||.||.|.|||||.|:..:.|..|||||||||:||:.|.||.:..: :|..|.|:
Mouse   475 QYPEIVFLGTGSAIPMKIRNVSSTLVNLSPDKSVLLDCGEGTFGQLCRHYGQQIDR-VLCSLTAV 538

  Fly   518 YVSHLHADHHIGLIGLLRERRQL----------KPRADPLILLAPRQIEPWLEFYNRQIETVEDA 572
            :|||||||||.||:.:|.:|...          || ..||:::||.|:..||:.|:...:.:...
Mouse   539 FVSHLHADHHTGLLNILLQREHALRSFFQASLGKP-FQPLLVVAPTQLRAWLQQYHNHCQEILHH 602

  Fly   573 YTLVGNGEL-LASPLSGEQVERL--------GITSISTCLVRHCPNSFGISLTLAAKHNSEPVKI 628
            .:::....| ..:.:|...:|||        .:....|||||||.::||.:|.     :|...|:
Mouse   603 VSMIPAKCLQKGAEVSNTTLERLISLLLETCDLEEFQTCLVRHCKHAFGCALV-----HSSGWKV 662

  Fly   629 TYSGDTMPCQDLIDLGRDSTVLIHEATMEDDLEEEARLKTHSTVSQAIQQGRNMNARHTILSHFS 693
            .||||||||:.|:.:|:|:|:||||||:||.|||||..|||||.||||..|..|||...:|:|||
Mouse   663 VYSGDTMPCEALVQMGKDATLLIHEATLEDGLEEEAVEKTHSTTSQAINVGMRMNAEFIMLNHFS 727

  Fly   694 QRYAKCPRLPSDEDMQRVAIAFDNMEVTVEDLQHYHKLYPALFAMYAEYTEELEQRAVKRELKQE 758
            |||||.| |.|.:..::|.||||:|:|...|.....||.|.|.|::|...||:.:|..||||:..
Mouse   728 QRYAKIP-LFSPDFNEKVGIAFDHMKVCFGDFPTVPKLIPPLKALFAGDIEEMVERREKRELRLV 791

  Fly   759 RKRKLAE 765
            |...|.:
Mouse   792 RAALLTQ 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNaseZ	NP_724916.1	metallo-hydrolase-like_MBL-fold	61..262	CDD:451500	77/258 (30%)
		RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold	457..655	CDD:293804	90/216 (42%)
		metallo-hydrolase-like_MBL-fold	<623..706	CDD:451500	52/82 (63%)
Elac2	XP_006534128.1	RNaseZ_ELAC2-N-term-like_MBL-fold	52..307	CDD:293854	77/259 (30%)
		RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold	479..689	CDD:293804	90/216 (42%)