Protein Alignment RNaseZ and trz2

DIOPT Version :10

• Sequence 1: NP_724916.1
• Gene: RNaseZ / 36086
• FlyBaseID: FBgn0028426
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: NP_595514.1
• Gene: trz2 / 2540985
• PomBaseID: SPBC3D6.03C
• Length: 678
• Species: Schizosaccharomyces pombe
• Alignment Length: 756
• Identity: 180/756 - (23%)
• Similarity: 291/756 - (38%)
• Gaps: 183/756 - (24%)

  Fly     2 YLVKSARSPI-YRTLRTLTTSNLMAATIASAK-DPLTGPRYEREPNVLRKKLASVVPGTVNLQVL 64
            |.||..:|.: :|......|:.:|.:.::|.. |.|..|
pombe    25 YSVKRWQSQLTFRNKSKRNTNRIMLSVVSSLNPDSLIAP-------------------------- 63

  Fly    65 GSGANGAPAAVYLFTDQARYLF-NCGEGTQ-RLAHEHKTRLSRLEQIFL------TQNTWASCGG 121
                     .:.:..|..:||. :.||.|| :...:......:...:||      :.|.|....|
pombe    64 ---------LLCVSLDNRKYLIGSMGELTQMKFRSQASNYGGKSVSVFLMPPSLQSLNAWGITAG 119

  Fly   122 LPGLTLTIQDAGVRDI-GLHGPPHLGSMLQSMRRFVVLKNLQVRPNDCSEGACFEDSILKVDSLP 185
            |.|.   :|.:|:::. |||.|..:.|:::.....                  |..|.|::| |.
pombe   120 LFGY---LQSSGIQNTWGLHAPKPVISIIKKSHHL------------------FSGSPLRLD-LN 162

  Fly   186 LINSEDPTKSVINY------ICQL---------------KPRAGALNLVKCVEQGVPPGPLLGQL 229
            ..:|||...:..::      .|.:               |..||..|..|.:..|||.||..|:|
pombe   163 SFSSEDNADATNSFYLDEPEFCTIKGNIYSNWSFLSFNSKEAAGVFNADKALALGVPFGPSNGKL 227

  Fly   230 KNGNDITLPDGKV-VRSVDVTEASETALSFVFLDVPSENYLPALLTHGKRLKKLGEEKLTEVALV 293
            ..|..:...||.. :....|.........|..|...|   |.||....|.:....:...|   .:
pombe   228 CAGEAVLSKDGTTWIYPHQVVGPPRKRQYFYVLGCSS---LSALNQMSKHVDSFSDVYPT---CI 286

  Fly   294 VHFTPYHISSRQVYKDFVVESFSSEAQHIYLSSPLNQFSGYAAAHRIQHQLHQLAPQVFPLLGEQ 358
            :|.....|...:..|              :||.|  :||      |.||.:..:          :
pombe   287 IHILEKGIWGPEYIK--------------FLSHP--KFS------RAQHFISCI----------E 319

  Fly   359 LSCQSQTLSLNLKKTKLDEADSEDKANAKANETEEQGVVAMTNYHLRPRKGLDRTLESKLTPEEY 423
            |:..:.....|..:..|.........:.|.:..:.|..:....|.|:..       .|.:..:|.
pombe   320 LASNNPVFQRNKGRNVLPACRDFAAFDIKPSTLDTQTQLPENTYVLKEE-------TSMVLYDEQ 377

  Fly   424 VKETHAVPGF--LELLAKFKEEYSFPDNSADSYPKIIFLGTGSCIPNKTRNVSSILIRTAID-AY 485
            .|.:.: |.:  ::|..||......|..: :.| .:..|||.:..|...|::||..:  ||| ..
pombe   378 CKISES-PSYSPVKLAKKFSSFNPLPFEN-EGY-TLDVLGTSATCPTWRRSLSSYSV--AIDGTV 437

  Fly   486 VLLDCGEGTYGQIVRLYGHEKGQLILRQLQAIYVSHLHADHHIGLIGLLRERRQLKPRADPLI-L 549
            ::||||||...|..|.|| ...:.:||:|:||:::|||:||::||:.:|:...:........| :
pombe   438 IMLDCGEGAISQFFRQYG-TNTEPMLRKLKAIFITHLHSDHYLGLLNVLQAWNKANTNNSMHINI 501

  Fly   550 LAPRQIEPWLE----------FYNRQI-----ETVEDAYTLVGNGELLASPLSGEQVERLGITSI 599
            :.|:.:..||:          ..||.|     |||.....       |.|.||...|..:.|...
pombe   502 IGPKFLWQWLQRLKSPANLQALLNRIIFIIAKETVTTPLQ-------LTSDLSISSVPSIHINDS 559

  Fly   600 STCLVRHCPNSFGISLTLAAKHNSEPVKITYSGDTMPCQDLIDLGRDSTVLIHEATMEDDLEEEA 664
            .:|::.|  ..:|              |:.|||||.|.:.|:..|..:::|:||:|.||||:.||
pombe   560 YSCIISH--TKYG--------------KLVYSGDTRPNEKLVKAGIGASLLLHESTFEDDLKHEA 608

  Fly   665 RLKTHSTVSQAIQQGRNMNARHTILSHFSQRYAKCPRLPSD 705
            ..:.|||.|:|:...::|.|:..||:|||||......||.|
pombe   609 IQRQHSTASEALSVAQSMKAKALILTHFSQRSYDADFLPPD 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNaseZ	NP_724916.1	metallo-hydrolase-like_MBL-fold	61..262	CDD:451500	47/231 (20%)
		RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold	457..655	CDD:293804	64/214 (30%)
		metallo-hydrolase-like_MBL-fold	<623..706	CDD:451500	36/83 (43%)
trz2	NP_595514.1	Lactamase_B_4	50..119	CDD:404562	15/103 (15%)
		metallo-hydrolase-like_MBL-fold	<198..>259	CDD:451500	17/60 (28%)
		RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold	413..599	CDD:293804	64/211 (30%)