DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CAP and MDC1

DIOPT Version :9

Sequence 1:NP_001369075.1 Gene:CAP / 36084 FlyBaseID:FBgn0033504 Length:2568 Species:Drosophila melanogaster
Sequence 2:XP_005249549.1 Gene:MDC1 / 9656 HGNCID:21163 Length:2110 Species:Homo sapiens


Alignment Length:2242 Identity:415/2242 - (18%)
Similarity:672/2242 - (29%) Gaps:795/2242 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 QNENHQQQAEGAEDREEQQDFQTQIAVAQ-----SSSFV----DDNGNS---------------- 69
            |.|...|:...|||.||:.||.::..:.:     |||.:    |:.|:|                
Human   175 QGETQPQRLLLAEDSEEEVDFLSERRMVKKSRTTSSSVIVPESDEEGHSPVLGGLGPPFAFNLNS 239

  Fly    70 -GSVSNGPTENSEEVTN------TLEKTEKKEEIF-------EQPATVIQKEADSDAEMGAKNSK 120
             ..|..|....:||.::      |:|..:.:.|:.       :||   :.||.|:|.        
Human   240 DTDVEEGQQPATEEASSAARRGATVEAKQSEAEVVTEIQLEKDQP---LVKERDNDT-------- 293

  Fly   121 HRKEKSDKQASNGKSEEQVRPPPTIIRR--PPGSPRQAKVIVHRIVREEDTANGKAQSPEPPKAV 183
                |..:.|.||     |.|...|:.|  |||               ||:.........||.  
Human   294 ----KVKRGAGNG-----VVPAGVILERSQPPG---------------EDSDTDVDDDSRPPG-- 332

  Fly   184 ESKEQHMEVEDSKKEKPEAQQEIETKEERENEP-SPKELPES------------------SHLSE 229
            ...|.|:|     :.:|....:.:|..|.|..| :|..:|..                  :||.|
Human   333 RPAEVHLE-----RAQPFGFIDSDTDAEEERIPATPVVIPMKKRKIFHGVGTRGPGAPGLAHLQE 392

  Fly   230 DAQQKHVEVEE------------------NQQVYDEVDYSKDET----TDNNPQQEQHDSKE--P 270
            .......:|||                  |....||.:.|...|    .::.|.....|::|  |
Human   393 SQAGSDTDVEEGKAPQAVPLEKSQASMVINSDTDDEEEVSAALTLAHLKESQPAIWNRDAEEDMP 457

  Fly   271 EQYVLQLEKAMEFVENAHQQHVAAVQSYQKQRDTEQNAQQQE---QNEAQHLQESTKAHQQNIAV 332
            ::.|| |:::....|                ||::.:.:::|   :|....|::.||..      
Human   458 QRVVL-LQRSQTTTE----------------RDSDTDVEEEELPVENREAVLKDHTKIR------ 499

  Fly   333 PQILVDPKKREEGLAQQLHHDVKEEPILNNAQQ--QNDDTAP-----KSPKEVTIKVQFQTEDPY 390
                          |....|..|::|...::..  :.|.::|     :|....|:.:..|.|   
Human   500 --------------ALVRAHSEKDQPPFGDSDDSVEADKSSPGIHLERSQASTTVDINTQVE--- 547

  Fly   391 SQQPPPQKPTSKVIIHQIHVETTDEEQNAKPTFEEVSSTTGSLAGTLSPPPRYLVES-------- 447
             ::.||......:..||:.||.|::        .:|.:..|        |.:.||.|        
Human   548 -KEVPPGSAIIHIKKHQVSVEGTNQ--------TDVKAVGG--------PAKLLVVSLEEAWPLH 595

  Fly   448 ---PKNVSSGQFSNFSRNVQIQEMELNSDFSSG--------------EFNSLQSPLVCEVDSESE 495
               ..:...|.....|....:::.:|.::..:|              |..:...|.|.:|:.:..
Human   596 GDCETDAEEGTSLTASVVADVRKSQLPAEGDAGAEWAAAVLKQERAHEVGAQGGPPVAQVEQDLP 660

  Fly   496 GS-------VV----LGPERSPSDQ--QVPSSSRVEQH-EQVRQKRAQYRNALESHFMPQLLNPR 546
            .|       ||    ||....|..:  |||:....||| ...:.....|.::.:       |:.:
Human   661 ISRENLTDLVVDTDTLGESTQPQREGAQVPTGREREQHVGGTKDSEDNYGDSED-------LDLQ 718

  Fly   547 YLDSILEENEWRNSTASSGGSDQTGIRTPKLNETFPRSQLDFSRRHKRREEAPSPLKLETK---- 607
            .....||........:......|..:.||.                  :|..||....:|.    
Human   719 ATQCFLENQGLEAVQSMEDEPTQAFMLTPP------------------QELGPSHCSFQTTGTLD 765

  Fly   608 -----------LLEESTDLES---CTRLQS---ALSP-------QSEDA----ELVYLSSSASSS 644
                       .|.||.|.|:   .|.|::   .|||       |..::    |.:.:......:
Human   766 EPWEVLATQPFCLRESEDSETQPFDTHLEAYGPCLSPPRAIPGDQHPESPVHTEPMGIQGRGRQT 830

  Fly   645 VSDLMELELEQAAAL----------AERALVDLDTDAS---------------RLIAR-----PD 679
            |..:|.:..|.|..:          .|:.|.:..||.:               :|:||     ..
Human   831 VDKVMGIPKETAERVGPERGPLERETEKLLPERQTDVTGEEELTKGKQDREQKQLLARDTQRQES 895

  Fly   680 DEMSSTSTTTADRSETEAETETETEREGEQSRESTPVNANPTLASSQSSLLSAATPTPTPTPTPA 744
            |:...:::...||...:.|.||..|.:.:|.::.|        ..|::.......|.......||
Human   896 DKNGESASPERDRESLKVEIETSEEIQEKQVQKQT--------LPSKAFEREVERPVANRECDPA 952

  Fly   745 DREQ------LAKDT---NVSGGSTVSFGAASPLAATREEFVRNMDKVRELIEMTRREQEQGELP 800
            :.|:      |.:||   ...|||....|.||  :.|.|..|                 ..|:||
Human   953 ELEEKVPKVILERDTQRGEPEGGSQDQKGQAS--SPTPEPGV-----------------GAGDLP 998

  Fly   801 RSPSPPPVPPPPASVPPYSPESSSFHLASL----QLKRQESNDSHCSDSTTHSQCTAINLASPPP 861
             .|:..|||....|....||.|...|...|    ....::::....::..:.....:.:...||.
Human   999 -GPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPPT 1062

  Fly   862 PPTAQPPTPPLRQKP---------APPPVPQPVSPPAPPT--------PQSEPELSVADSVANAN 909
            .|.|  |.||  |||         ||||:..|:.|...||        .|..||           
Human  1063 VPEA--PAPP--QKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPE----------- 1112

  Fly   910 ADVDADADTDTEAI---KKLRLLCTEQLASMPYGEQVLE--ELASVAQNI----------SDQSQ 959
                |...::.|..   .|:|...:.::...|......|  ...|.||.:          |..::
Human  1113 ----APLSSELEPFHPKPKIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNR 1173

  Fly   960 NKMPYPMPQLPHIKELQLNANESKSSSAWLGLPTQSDPKLLVCLSPGQRDLVNN---------QT 1015
            :.:..|.|.:|...|||.:.:..:        |..|:|...|......|..|..         :.
Human  1174 SSVKTPEPVVPTAPELQPSTSTDQ--------PVTSEPTSQVTRGRKSRSSVKTPETVVPTALEL 1230

  Fly  1016 QPDDLLDAHQKFVERRGYHELSKAQVLEQDHQQQQSEMLKTAAMMRELRKSLSPPAPPVPPPPVP 1080
            ||....|                        :...||....|...|:.|.|:..|.|.||..|..
Human  1231 QPSTSTD------------------------RPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPEL 1271

  Fly  1081 VKSAETAAKATAHENAKRDDASEQKQKIAACE---SSSLENKPRRAADLGAQQSAEQRQSSSTTT 1142
            ..|..|....|:....:.....:.:..:...|   .::.|.:|..:.|.........|.:.|.|.
Human  1272 QPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTN 1336

  Fly  1143 SSHKATTETMSSDTAKFPTLDSMESELARMFPQHKGDIFEEQRKRFSNIEFPSHQPVSQTKRYSN 1207
            .|...|.||:      .||...::                        |...:.|||  |.:.::
Human  1337 MSSVKTPETV------VPTAPELQ------------------------ISTSTDQPV--TPKPTS 1369

  Fly  1208 IETSSYESKKRMENGQVVYDVSTSSHEKKEQGDPPKDQPVPPVPPPPIMSAT------------- 1259
            ..|.|..:...::|.:....::...        ||......||.|.|...||             
Human  1370 RTTRSRTNMSSVKNPESTVPIAPEL--------PPSTSTEQPVTPEPTSRATRGRKNRSSGKTPE 1426

  Fly  1260 -------KLNGNTFIDGDVAPKNSQPSRESGSGSGNGTYEEFRQRAKAAADAFGEQREQQNGLDQ 1317
                   ||..:|..|..|.|   :|:.::..|..|      |...|..........|.|.....
Human  1427 TLVPTAPKLEPSTSTDQPVTP---EPTSQATRGRTN------RSSVKTPETVVPTAPELQPSTST 1482

  Fly  1318 DRVFKDFDRLSQQMHAE--LQSTREKREKSASMYDLSGFTRPASGHPRLDELQQRRHAHMQELER 1380
            |          |.:..|  .|:||.:.::|:       ...|.:..|...|||............
Human  1483 D----------QPVTPEPTSQATRGRTDRSS-------VKTPETVVPTAPELQASASTDQPVTSE 1530

  Fly  1381 EIERSAKSRQERMS------SVPRQMEATPPRTHEIPIELEPRSRRA------------ESL--- 1424
            ...|:.:.|:.|.|      .||...|..|..:.:.|:..||.||..            ||:   
Human  1531 PTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPI 1595

  Fly  1425 ------------------------CNLN-------EP----PPRPHTTVGHYNHPVVQDDWSR-- 1452
                                    |..|       ||    .|.||.|.. .:.||.....||  
Human  1596 APELQPSTSRNQLVTPEPTSRATRCRTNRSSVKTPEPVVPTAPEPHPTTS-TDQPVTPKLTSRAT 1659

  Fly  1453 -----------------YANDL------------------GYSENIARPFAREVEICYQRQNQ-- 1480
                             .|:||                  |.|:.:.....|.:.:....:.|  
Human  1660 RRKTNRSSVKTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEFQSP 1724

  Fly  1481 ------------RTPHCIRAPRLSASTNDLSSSSQYSYDTFNAYGGRRTHAPMLNQAQQQQRPHY 1533
                        ..|.||:..|.:.:...|::...:          :...||:..::|..:...:
Human  1725 VTTDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDH----------KPCSAPLEPKSQASRNQRW 1779

  Fly  1534 GS-----CYSMIERDPNPRYISTTSRRGVSPAPPPVATPQQQQVPPPAYDRQQRRSSLPRELHEQ 1593
            |:     ..:.|....:|:.:.|           |:...|.|:|.|..      ||....||.  
Human  1780 GAVRAAESLTAIPEPASPQLLET-----------PIHASQIQKVEPAG------RSRFTPELQ-- 1825

  Fly  1594 QLKYILSKEEELKFEVERLQQERRRLMEEMQRAPVLPAPQR----------RESYRPAAKLPTLS 1648
                            .:..|.|:|.:..|...|....|||          :|.....|:.|...
Human  1826 ----------------PKASQSRKRSLATMDSPPHQKQPQRGEVSQKTVIIKEEEEDTAEKPGKE 1874

  Fly  1649 EDEVF------RQQMAEEWMNKVAEREERRQH--------KIIRISKIE---------------- 1683
            ||.|.      ::..|||..|::..|..||..        |::....::                
Human  1875 EDVVTPKPGKRKRDQAEEEPNRIPSRSLRRTKLNQESTAPKVLFTGVVDARGERAVLALGGSLAG 1939

  Fly  1684 --DEHDHSAVDKATISDEFLDRVKERRHKLSMPADSDW-----ESGAESQPQPAAQSQPESD--- 1738
              .|..|...|:...:.:||..:......||:    ||     ::|....|.....:.||.:   
Human  1940 SAAEASHLVTDRIRRTVKFLCALGRGIPILSL----DWLHQSRKAGFFLPPDEYVVTDPEQEKNF 2000

  Fly  1739 --------VEAPPVRILEG---QAEANLRQLPRHLREFAKFSTSEQLPDGAQMERHEEQERREEA 1792
                    ..|...|:|||   .....::..|..:.|.........||                 
Human  2001 GFSLQDALSRARERRLLEGYEIYVTPGVQPPPPQMGEIISCCGGTYLP----------------- 2048

  Fly  1793 TDNAHSSATKKTSIVKTYKVSRLPPSVQGEFP 1824
                        |:.::||..|:..:...:||
Human  2049 ------------SMPRSYKPQRVVITCPQDFP 2068

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CAPNP_001369075.1 MDN1 <43..328 CDD:227596 75/371 (20%)
Sorb 1959..2003 CDD:413404
SH3_Sorbs_1 2315..2367 CDD:212715
SH3_Sorbs_2 2384..2436 CDD:212716
SH3_Sorbs_3 2514..2567 CDD:212714
MDC1XP_005249549.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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