DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAP and SORBS2

DIOPT Version :9

Sequence 1:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster
Sequence 2:	XP_016864227.1	Gene:	SORBS2 / 8470	HGNCID:	24098	Length:	1408	Species:	Homo sapiens

Alignment Length:	1535	Identity:	301/1535 - (19%)
Similarity:	502/1535 - (32%)	Gaps:	460/1535 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   347 AQQLHHDVKEEPILNNAQQQNDDTAPKSPKEVTIKVQFQTEDPYSQQPPPQKP-----------T 400
            |.:.::|..:|.:  |........|.|..:.|...:| ....|....|||::.           |
Human    44 AWRSYNDGNQETL--NGDATYSSLAAKGFRSVRPNLQ-DKRSPTQAPPPPERKESFHSSLITSHT 105

  Fly   401 SKVIIHQIHVET-----TDEEQNAKP---------------TFEEVSSTTGS----------LAG 435
            ..||:.|:...|     |:...|.||               .:.|.|:||.|          .|.
Human   106 KGVILDQLVTNTQIPSSTEYFANKKPLQGTMYSNEDSRQTIVYSEESNTTMSYTQKITNPLPAAS 170

  Fly   436 TLSPPPRYLVESPKNVSSGQFSNFSRNVQIQEMELNSDFSSGEFNSLQSPLVCEVDSESEGSVVL 500
            :..|.|...:.:|  |....:...|:..:|..::|..:...|..:.:.:|   :.....|....|
Human   171 STDPAPFANINTP--VLQEDYRQDSQTRRISTLKLTHNQDLGSSSPISTP---QFSKSVEVPSFL 230

  Fly   501 GPERSPSDQQVPSSSRVEQHEQVRQKRAQYRNALESHFMPQLLNPRYLDSILEENEWRNSTASSG 565
            ...||.:...||.:.......|:.....|   .||||.....|:|......|::...:::.|::.
Human   231 KRPRSLTPNPVPETHTASLSIQIAPLSGQ---DLESHKQLPELSPETAKIPLQQERQKSAVAAAS 292

  Fly   566 GSDQTGIRTPKLNETFPRSQLDFSRRHKRRE---EAPSPLKLETKLLEESTDLESCTRLQSALSP 627
            .|....:..   |:..|.|.|:.:.....|:   ||..|.......|..:|           .||
Human   293 QSSDCRVLG---NQNLPASVLEVNASQTHRQTTPEASPPCPPSVVPLNRAT-----------FSP 343

  Fly   628 QSEDAELVYLSSSASSSV---SDLMELELEQAAALAERALVDLDTDASRLIARPDDEMSSTSTTT 689
            .|.       :||||.|:   ..:....|....:|:......|......||...|....:|.::.
Human   344 GSG-------TSSASLSLPPPDGVGSSRLHNPQSLSHCLYKHLLPAPESLIHSHDTGSLTTDSSL 401

  Fly   690 AD---RSETEAET----ETETEREGEQSRESTPVNANPTLASSQSSLLSAATPTPTPTPTPADRE 747
            |:   |||:|:.|    |.:........|..||   :||.  .|.|.::..|...||..|   ..
Human   402 AEHSSRSESESSTAMLEELQIGDSDTTGRSETP---SPTW--GQRSAVTDGTTLTTPAAT---HS 458

  Fly   748 QLAKDTNVSGGSTVSFGAASPLAATREEF--------------------------------VRNM 780
            |:..:.|       |.||.||::..:..|                                .:::
Human   459 QITVNGN-------SGGAVSPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSL 516

  Fly   781 D-KVRELIEMTRREQEQGELP--RSPSPPPVPPP-----PASV---------------------- 815
            | .....|.:.|..:|:..:.  ::|..|.:.|.     |.::
Human   517 DGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVH 581

  Fly   816 ---------------------PPYSPESSSFHLASLQLKRQESNDSHCSDSTTHSQCTAINLASP 859
                                 ||||.:|   |.|:.....:..:.|| ||::.::...|   :||
Human   582 KPDDDTDMYNTPYTYNAGLYNPPYSAQS---HPAAKTQTYRPLSKSH-SDNSPNAFKDA---SSP 639

  Fly   860 PPPPTAQPPTPPLRQKPAPPPVPQPVSPPAPPTPQSEPELSVADSVANANADVDADADTDTEAIK 924
            .|||...||.||||.:...........||                          |...||   :
Human   640 VPPPHVPPPVPPLRPRDRSSTEKHDWDPP--------------------------DRKVDT---R 675

  Fly   925 KLRLLCTEQLASMPY--GEQVLEELASVAQNISDQSQNKMPYPMPQLPHIKELQLN----ANESK 983
            |.|   :|..:...|  |:      :|:.|:.........|.|:|:.|..|.|..:    ...|.
Human   676 KFR---SEPRSIFEYEPGK------SSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSP 731

  Fly   984 SSSAWLGLPTQSD--PKLLVCLSPGQRDLVNNQTQPDDL---LDAHQKFVERRGYHELSKAQVLE 1043
            |.....|.||.|.  |    .|||.:.|.:|    |||:   .:...||.....:......:.|:
Human   732 SPPPRSGAPTPSSRAP----ALSPTRTDRIN----PDDIDLENEPWYKFFSELEFGRPPPKKPLD 788

  Fly  1044 --QDHQQQQSEMLKTAAMMR-ELRKSLSPPAPPVPPPPVPVKSAETAAKATAHENAKRDDASEQK 1105
              |||   .|.:...|::.: .:.:||..          |:.||..|:          |....:|
Human   789 YVQDH---SSGVFNEASLYQSSIDRSLER----------PMSSASMAS----------DFRKRRK 830

  Fly  1106 QKIAACESSSLENKPRRAADLGAQQSAEQR----QSSST-----TTSSHKATTETMSSDTAKF-P 1160
            .:.|.       ..||...|..|.:::..|    .||:|     |:||..:.:.....|.:|. |
Human   831 SEPAV-------GPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICP 888

  Fly  1161 TL---------DSMESELARMFPQHKGDIFEEQRKRFSNIEFPSHQPVSQTKRYSNIETSSYESK 1216
            :|         .|.|.:....:.||              ::.|...|          ...|:::.
Human   889 SLCSYSGLNGNPSSELDYCSTYRQH--------------LDVPRDSP----------RAISFKNG 929

  Fly  1217 KRM--ENGQV--VYDVSTSSHEKKEQGDPPKDQPVPPVPPPPIMSATKLNGNTFIDGDVAPKNSQ 1277
            .:|  :|.::  ..:.:.|...|....|...:......|.|.:.|.:.  |:...:.|
Human   930 WQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESM--GSLLCEED------- 985

  Fly  1278 PSRESGSGSGNGTY-EEFRQRAKAAADAFGEQREQQNGLDQDRVFKDFDRLSQQ--MHAE----- 1334
             |:||...:....| .|.|...::..    ..|..:|.....:::|...|::::  |::|
Human   986 -SKESCPMAWGSPYVPEVRSNGRSRI----RHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSV 1045

  Fly  1335 ----LQSTREKREKSASMYDLSGFTRPASGHPRLDELQQRRHAHMQELEREIERSAKSR----QE 1391
                ||...|::.|..    |..:::.::.....|.:..|    :.|.|:.|::| ||.    .:
Human  1046 KSRILQYESEQQHKDL----LRAWSQCSTEEVPRDMVPTR----ISEFEKLIQKS-KSMPNLGDD 1101

  Fly  1392 RMSSV---PRQMEATPPRTHEIPIELE--------PRSRRAESLCNLN-----------EPPPRP 1434
            .:|.|   |.|....|.|...|...||        .|.||.   |..|           :..||.
Human  1102 MLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRRG---CQSNALVPIHIEVTSDEQPRA 1163

  Fly  1435 HTTVGHYNHPVVQDDWSRYANDLGYSENIARPFAREVEICYQRQNQRTPHCIRAPRLSASTNDLS 1499
            |......:...|..|.|.|.:..|.|            .|                   |.:|..
Human  1164 HVEFSDSDQDGVVSDHSDYIHLEGSS------------FC-------------------SESDFD 1197

  Fly  1500 SSSQYSYDTFNAYGGRRTHAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSRRGVSPAPPPV 1564
            ..|..|.::|  ||....|.   :......|....||..   |.|......||..:.........
Human  1198 HFSFTSSESF--YGSSHHHH---HHHHHHHRHLISSCKG---RCPASYTRFTTMLKHERARHENT 1254

  Fly  1565 ATPQQQQVPP----------PAYDRQQRRSSLPRELHEQQLKYIL--SKEEELKFEVERLQQERR 1617
            ..|::|::.|          |...|:::.|:..::..:.:.|..:  :.:..||...::::.|::
Human  1255 EEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKK 1319

  Fly  1618 -----------RLMEEMQRAPVLP-APQRRESYRPAAKLP 1645
                       ||:.|:     || .|:|..|.|...:.|
Human  1320 RGSLPDNSILHRLISEL-----LPDVPERNSSLRALRRSP 1354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404
		SH3_Sorbs_1	2315..2367	CDD:212715
		SH3_Sorbs_2	2384..2436	CDD:212716
		SH3_Sorbs_3	2514..2567	CDD:212714
SORBS2	XP_016864227.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7841
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40780
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8484
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940