Protein Alignment CAP and SORBS2

DIOPT Version :10

• Sequence 1: NP_001369075.1
• Gene: CAP / 36084
• FlyBaseID: FBgn0033504
• Length: 2568
• Species: Drosophila melanogaster
• Sequence 2: NP_001382136.1
• Gene: SORBS2 / 8470
• HGNCID: 24098
• Length: 1300
• Species: Homo sapiens
• Alignment Length: 1288
• Identity: 312/1288 - (24%)
• Similarity: 454/1288 - (35%)
• Gaps: 432/1288 - (33%)

  Fly  1506 YDTFNAYGGRRTHAPMLNQAQ-----QQQRPHYGSCYSMIERDPNPRYISTTSRRGVSPAPPPVA 1565
            |:|...|.....:.|...|:.     |..||     .|....|.:|......|    ||.|||
Human   218 YNTPYTYNAGLYNPPYSAQSHPAAKTQTYRP-----LSKSHSDNSPNAFKDAS----SPVPPP-- 271

  Fly  1566 TPQQQQVPPPAYD-RQQRRSSLPRELHEQQLKYILSKEEELKFEVERLQQERRRLME-------- 1621
                 .||||... |.:.|||  .|.|:..       ..:.|.:..:.:.|.|.:.|
Human   272 -----HVPPPVPPLRPRDRSS--TEKHDWD-------PPDRKVDTRKFRSEPRSIFEYEPGKSSI 322

  Fly  1622 -EMQRAPVLPA----------------------------PQRRESYRPAAKLPTLS--------E 1649
             :.:|.|.||.                            |.|..:..|:::.|.||        .
Human   323 LQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRTDRINP 387

  Fly  1650 DEVFRQQMAEEWMNKVAEREERRQHKIIRISKIEDEHDHSAVDKATISDEFLDRVKERRHKLSMP 1714
            |::..:.  |.|....:|.|..|......:..::| |.....::|::....:||..||....:..
Human   388 DDIDLEN--EPWYKFFSELEFGRPPPKKPLDYVQD-HSSGVFNEASLYQSSIDRSLERPMSSASM 449

  Fly  1715 ADSDWESGAESQPQ--PAAQSQPESDVEAPPVRILEGQAEANLRQLPRHLREFAKFSTSEQLPDG 1777
            | ||:....:|:|.  |......:|.....|.|:          .||.......|..||..
Human   450 A-SDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV----------DLPGSSTTLTKSFTSSS---- 499

  Fly  1778 AQMERHEEQERREEATDNA------------HSSATKKTSIVKTYKVSRLPPSVQGEFPGQFSGG 1830
                  .....|.:..|::            :.:.:.:.....||   |....|..:.|...|..
Human   500 ------PSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTY---RQHLDVPRDSPRAISFK 555

  Fly  1831 NRGRLYRER----SQTARLVSHNIPLELTSNHSSSPDSDFNPGCGSSPAPGSSTQSSIPSLVQSP 1891
            |..::.|:.    |.|...||..|       .|.|.|...|..|.|.|.|...::|....|.:..
Human   556 NGWQMARQNAEIWSSTEETVSPKI-------KSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEED 613

  Fly  1892 TPAPPP-----PIEP----------LNPSSSTAGGILGTALLLGLSLLTAWNKFIYKVKH----- 1936
            :....|     |..|          .:.|:..|.|.|.                :||..|
Human   614 SKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLK----------------MYKKMHRINRK 662

  Fly  1937 ----------------EYMSEPETGSDRPRKMAQLGRRQYDGIGPVTNDGMPIILRSEVKEPHQH 1985
                            :|.|| :...|..|..:|....:      |..|.:|    :.:.|
Human   663 DLMNSEVICSVKSRILQYESE-QQHKDLLRAWSQCSTEE------VPRDMVP----TRISE---- 712

  Fly  1986 EWYKRLYQTIHKQKN-GDD-------------------FVIRYKC---------PRARPSYKSNG 2021
              :::|.|......| |||                   |.|.|..         .|.|...:||.
Human   713 --FEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNA 775

  Fly  2022 YV-------SEPEPN-----YDSDYSTVRYRTQNPHRVQSVSSAVNVR-------------NLNQ 2061
            .|       |:.:|.     .|||...|         |...|..:::.             :...
Human   776 LVPIHIEVTSDEQPRAHVEFSDSDQDGV---------VSDHSDYIHLEGSSFCSESDFDHFSFTS 831

  Fly  2062 DEKLYGTMPNP-----------IKSAQN----SYKNQPGRIENYTTGHSSVSEKEKKEWWDEVMD 2111
            .|..||:..:.           |.|.:.    ||......:::....|.:..|..::|     ||
Human   832 SESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQE-----MD 891

  Fly  2112 IFNGNL---------------------EQSKLSPLYTEGNLSRAL---------AKESGYTSDSN 2146
            .....|                     |::|......|. |..||         .|:.|...|::
Human   892 PGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEA-LDSALKDICDQIKAEKKRGSLPDNS 955

  Fly  2147 LVFRKKEVPVSSPLSPVEQKQAYKSLQAGGEPPLLGFRKPAPEKPRDLDPNAPPIPPQPPVKGLS 2211
            ::.|.    :|..|..|.::.:  ||:|....||                 ..|:.|.||...:
Human   956 ILHRL----ISELLPDVPERNS--SLRALRRSPL-----------------HQPLHPLPPDGAI- 996

  Fly  2212 SYDFPYSTD-----------TVDGSDVNIHFKTPIRHEQRQNLSEEELAIRQAEHMQKLYHEERR 2265
             :..||..|           .||.::.:.|      |:.|..               .|...|..
Human   997 -HCPPYQNDCGRMPRSASFQDVDTANSSCH------HQDRGG---------------ALQDRESP 1039

  Fly  2266 RKYLQELQDM-NSRRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKE 2329
            |.|...|.|| .|.......||.::                       |..|:|:::|:.|||||
Human  1040 RSYSSTLTDMGRSAPRERRGTPEKE-----------------------KLPAKAVYDFKAQTSKE 1081

  Fly  2330 LSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSK-----RPSE-GQARAK 2388
            |||:||||:||.|:||.|||||||:..:|:.|.||||.::......|::     :|.| |:|.||
Human  1082 LSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK 1146

  Fly  2389 YNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKI--ANRKGIFPCSYVEVL--TDIGAEDIAART 2449
            |||.|.:.:||||.||:.|.|.:|||.||:||||  .||:||||.|||||:  ...||||.
Human  1147 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDY---- 1207

  Fly  2450 TTVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQPPNGILKETRTLHKTDALHVDTSSEPLAY 2514
                         |:..:..:..::..::|:.|..|.|       ...|:    ::....||  :
Human  1208 -------------PDPPIPHSYSSDRIHSLSSNKPQRP-------VFTHE----NIQGGGEP--F 1246

  Fly  2515 RALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYVER 2567
            :|||.|.|:|.|||||.|.||:.|:||||||||||||:||..|||||||||:|
Human  1247 QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKR 1299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	Sorb	1959..2003	CDD:470634	8/44 (18%)
		SH3_Sorbs_1	2315..2367	CDD:212715	32/51 (63%)
		SH3_Sorbs_2	2384..2436	CDD:212716	33/53 (62%)
		SH3_Sorbs_3	2514..2567	CDD:212714	38/52 (73%)
SORBS2	NP_001382136.1	Sorb	170..214	CDD:460492
		SH3_Sorbs2_1	1066..1120	CDD:212853	33/53 (62%)
		SH3_Sorbs2_2	1141..1197	CDD:212856	35/55 (64%)
		SH3_Sorbs2_3	1240..1300	CDD:212850	41/62 (66%)