Protein Alignment CAP and sorbs2a

DIOPT Version :10

• Sequence 1: NP_001369075.1
• Gene: CAP / 36084
• FlyBaseID: FBgn0033504
• Length: 2568
• Species: Drosophila melanogaster
• Sequence 2: XP_073805841.1
• Gene: sorbs2a / 571008
• ZFINID: ZDB-GENE-070308-2
• Length: 2130
• Species: Danio rerio
• Alignment Length: 2680
• Identity: 484/2680 - (18%)
• Similarity: 740/2680 - (27%)
• Gaps: 1279/2680 - (47%)

  Fly   611 ESTDLESCTRLQSALS------PQSEDAELVYLSSSASSSVSDLMELELEQAAALAERALVDLDT 669
            ::.|...|...:::||      .:.:....:|.::.:.|..|                     |:
Zfish     4 DTPDSGGCAHKRASLSLTLWPVKRVQSTPNLYTAAGSDSQSS---------------------DS 47

  Fly   670 DA--SRLIA---RPDDEMSSTSTTTADRS------ETEAETETETEREGEQSRESTP-------- 715
            ||  ||.::   |..|..||:.|:...||      :.::.|.........:|...||
Zfish    48 DAWRSRSVSEGLRNGDAGSSSLTSKGFRSVKPNLQDKKSPTPVPLPPPRRESYHMTPNPPSYSSL 112

  Fly   716 -VNANPTLASSQS---------SLLSAAT-------PTPTPTPTP-ADREQLAKDTNVSGGSTVS 762
             :.:|.|.:.|||         |:.|:||       .|.|.|.|. |..|:.......:..|.:|
Zfish   113 AMLSNATFSPSQSHDAISTGSYSIQSSATSSYSYSKTTRTSTNTSGAPLEESPSSQQANANSFIS 177

  Fly   763 FGAASPLAATREEFVRNMDKVRELIEMTRREQEQGELPRSPSPP-----PVPPPPASVPPYSPES 822
            ....|.|::::  |..:......:..|...:      |::.:.|     |.|..|||       :
Zfish   178 RVLGSKLSSSK--FATDQLNAAPVTNMITTD------PKTKTKPKGAFTPSPLDPAS-------T 227

  Fly   823 SSFHLASLQLKRQESNDSHCSDSTTHSQCTAINLASPPPPPTAQPPTP---------PLRQKPAP 878
            |..|:|||.::....:....::|.:..:..|:::.....||.. ||.|         |:|..|.|
Zfish   228 SDSHIASLSIQLAPRSPEPRAESRSEPRTNAVDITDSTRPPVI-PPRPAGSLVREFSPVRGGPGP 291

  Fly   879 ----PPVPQPVSPPAP---------------------PTPQSEPELSVADSVANANADVDADADT 918
                |..|.|.:..:|                     |||.:..|.|...|.:.|.:.|...|
Zfish   292 ISSGPSSPDPAARRSPYSRASQDSPDFLSGLLPKALSPTPYAPLERSGLMSASPAVSPVTVSA-- 354

  Fly   919 DTEAIKKLRLLCTEQLASMPYGEQVLEELASVAQNISDQSQNKMPYPMPQLPHIKELQLNANESK 983
                        ..|.:|...|   ||||....   .|.|....|.|.|.|.|....   |:|.:
Zfish   355 ------------LSQYSSSTAG---LEELQICG---LDSSPLATPTPSPTLSHTSNA---ADELQ 398

  Fly   984 S-SSAWLGLPTQSDPKLLVCLSPGQRDLVNNQTQPDDLLDAHQKFVERRGYHELSKAQVLEQDHQ 1047
            | .||..|             :.||. .||..:|.
Zfish   399 SIPSAATG-------------TNGQM-TVNGSSQS------------------------------ 419

  Fly  1048 QQQSEMLKTAAMMRELRKSLSPPAPPVPPPPVPVKSAETAAKATAHENAKRDDASEQKQKIAACE 1112
                            ::..||||.| ||||.|:.|.........|       :||..|.:.  .
Zfish   420 ----------------QRPFSPPAHP-PPPPPPILSPGLVQIQHGH-------SSEGSQTLR--R 458

  Fly  1113 SSSLENKPRRAADLGAQQSAEQRQSSSTTTSSHKATTETMSSDTAKFP-----TLDSMESELARM 1172
            .|.:..:...::.:...:.:|:.:..|...:.|......:  |.:..|     |:|..:.....|
Zfish   459 ESVVSGQTVVSSSVPIARFSEEEKKVSVIKAPHYEGIGPV--DESGIPIAIRTTVDRPKDWYKTM 521

  Fly  1173 FPQ----HK-----GDIFEEQRKRFSNIEFP---SHQPVSQTKRYSNIETSSYESKKRMENGQVV 1225
            |.|    ||     .|.:.......:|..:|   :|.|.         .|.:|....|..:
Zfish   522 FKQIHMVHKPDDDYADTYNATYAVINNDNYPPVHAHPPP---------RTHTYRPLSRNTS---- 573

  Fly  1226 YDVSTSSHEKKEQGDPPKDQPVPPVPPPPIMSATKLNGNTFIDGDVAPKNSQPSRESGSGSGNGT 1290
             |:..|:.:::     ....|||| ||||:.|..:|...   |.|...:.|....|.|.......
Zfish   574 -DIPDSAAQRE-----LSPSPVPP-PPPPMPSLLQLRSR---DMDREKEFSHDPNEWGPPERKVD 628

  Fly  1291 YEEFRQRAKAAADAFGEQREQQNGLDQDR-VF----KDFDRLSQ---QMHAELQSTREKREK--- 1344
            ..::|...::   .|..:..:.:.|:|:| .|    .|.|..::   :..:||:..|...:|
Zfish   629 TRKYRAEPRS---IFEYEPGKSSILEQERPTFDLNPDDIDLENEPWFKFFSELEFGRPPPKKRLD 690

  Fly  1345 -----------SASMYDLSGFTRPASGHPRLDELQQRRHAHMQELEREIERSAKSRQERMSSV-P 1397
                       .:|:| :|...||........:.::||.:     |..:.::....::..|.| .
Zfish   691 YNPDYSTHTVAQSSLY-ISPSERPDGPSSSASDYRKRRKS-----EPSVTQANTGSEQNASQVFS 749

  Fly  1398 RQMEATPPRTHEIP-IELEPRS-RRA------ESLCNLNEPP--PRPHTTVGHYNHPVVQDDWSR 1452
            |.::::..:|.:.| |...|.| .||      |||.:....|  .||.:.:...:..:....|
Zfish   750 RTLDSSKAQTLKKPTIRSSPSSPSRAKAGDFSESLSSCMSSPGMERPSSRISTDSLTISTPTW-- 812

  Fly  1453 YANDLGYSENIARPFAREVEICYQRQNQRTPHCIRAPRLSASTNDLSSSSQYSYDTFNAYGGRRT 1517
                         |.::. .||::...|...|        .:|.:.||:...|..|        .
Zfish   813 -------------PSSKR-SICFKNGWQTGRH--------ENTENWSSADDDSAMT--------P 847

  Fly  1518 HAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSRRGVSPAPPPVATPQQQQVPPPAYDRQQR 1582
            .:|.|...         ||..::    :..:.:||:..|             ::..|.:..|.:.
Zfish   848 TSPRLKSR---------SCDDLL----SDGHGATTNNNG-------------REANPVSNTRSES 886

  Fly  1583 RSSL-PRELHEQQLKYILSKEEELKFEVERLQQERRRLMEEMQRAPVLPAPQRRESYRPAAKLPT 1646
            ..|| ..|..:.|:|.:.|                              :|:.|..:|  .|||
Zfish   887 AGSLIDEEAQKPQVKSLTS------------------------------SPRGRRHHR--RKLP- 918

  Fly  1647 LSEDEVFRQQMAEEWMNKVAEREERRQHKIIRISKIEDEHDHSAVDKATISDEFLDRVKERRHKL 1711
                                                   ||         :..||...|:..|
Zfish   919 ---------------------------------------HD---------APGFLQLYKKMHH-- 933

  Fly  1712 SMPADSDWESGAESQPQPAAQSQPESDVEAPPVRILEGQAEANLRQLPRHLREFAKFSTSEQLPD 1776
                 .|.|           |..|...:.:...||||
Zfish   934 -----IDRE-----------QLLPSEVIRSVRARILE---------------------------- 954

  Fly  1777 GAQMERHEEQERREEATDNAHSSATKKTSIVKTYKVSRLPPSVQGEFPGQFSGGNRGRLYRERSQ 1841
               :||.::|:|.                            |:.|..|
Zfish   955 ---LERLQQQQRH----------------------------SIHGWAP----------------- 971

  Fly  1842 TARLVSHNIPLELTSNH-----------SSSPD-SDFNPGCGSSPAPGSSTQSSIP-------SL 1887
                :.|.:|.::..|.           .|.|| .|.|...|:: .||||..||.|       ||
Zfish   972 ----LGHEVPRQMVPNRISAYEQLIQKSKSMPDLGDENAPSGTT-TPGSSRASSCPKRRFSVESL 1031

  Fly  1888 VQSPTPAPPPPIEPLNPSSSTAGGILGTALLLGLSLLTAWNKFIYKVKHEYMSEPETGSDRPRKM 1952
            ::...|       |.|..|...|                              :|..|:|....:
Zfish  1032 LEEEDP-------PENARSPPEG------------------------------QPRLGADSLVPI 1059

  Fly  1953 AQLGRRQYDG------------IGPVTNDGMPIILRSEVKE-------------PHQHEWYKRLY 1992
            ....:||:..            |..:..:|..:...|::..             .|.|..:...|
Zfish  1060 HGKNQRQHQDYSDSEQDACASEISDIHIEGSSLCSESDLDHCSLTSSESFYGSGQHHHHGHHHHY 1124

  Fly  1993 QTIHKQKNGDDFVIRYKCPRARPSYKSNGYVSEPEPNYDSDYSTVRYRTQNPHRVQSVSSAVNVR 2057
            ...|.|..|                :|.||                   |:.|.:.|.....
Zfish  1125 HRHHHQSVG----------------QSQGY-------------------QHRHLISSCKGRC--- 1151

  Fly  2058 NLNQDEKLYGTMPNPIKSAQNSYKNQPGRIENYTT--GHSSVSEKEKKEWWDEVMDIFNGNLEQS 2120
                                      |.....:||  .|....|:.::|....:.
Zfish  1152 --------------------------PASYTRFTTMLKHERQQERARQESHPAIS---------- 1180

  Fly  2121 KLSPLYTEGNLSRALAKESGYTSDSNLV----FRKKEVPVSSPLS---------PVEQKQAYKSL 2172
              ||      |::....|||.:..:.||    ||:|.   .||.:         |..:...|::|
Zfish  1181 --SP------LAQQSPSESGLSKLAFLVSPVPFRRKR---GSPPTQRRHCRSGRPKSKTAIYEAL 1234

  Fly  2173 QA-------------GGEPPLLGFRKPAPEKP---RDLDPNAPPIPPQPPVKGLSSYDFPYSTDT 2221
            .|             |.||..:      |:..   |.|:...|.:|     |..||    .....
Zfish  1235 DAALQDIYDHIRAEKGQEPARM------PDDSILRRLLEELLPDVP-----KRSSS----LRVQR 1284

  Fly  2222 VDGSDVNIHFKTPIRHEQRQNLSEEELAIRQAEHMQKLYHEERRRK------YLQELQDM----- 2275
            ..||..:.|...|. |...|..|     .:|..|:....:..:...      |..:..|.
Zfish  1285 GSGSPSSSHVHQPY-HGAHQCAS-----YQQQHHLADTSNNNQHSTNANVHCYSDQGSDTGRITP 1343

  Fly  2276 NSRRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYI 2340
            .|||.|.....|.|.          .|.:.|.||:..|..|||:::|:.|::||:||:|||.:.|
Zfish  1344 QSRRLTPEREVSSKQ----------MTYLILSSLLHQKQSARAIYDFKAQSAKEISFKKGDAVNI 1398

  Fly  2341 RRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSKRPSEGQAR------AKYNFQAQSGIEL 2399
            .||||:|||||||...||:.|.||||.|:....|.|.:.|...|.|      |:|||.|.:.:||
Zfish  1399 IRQIDSNWYEGEHRGRIGIFPISYVEKVASPERRQPVRPPPPAQVREMGEAIARYNFNADTNVEL 1463

  Fly  2400 SLNKGELVTLTRRVDGNWFEGKI--ANRKGIFPCSYVEVLTDIGAE------------------- 2443
            ||.|||.|.|.|:||.||:||||  :|::||||.|||:|:....::
Zfish  1464 SLRKGERVILLRKVDQNWYEGKIPGSNKQGIFPVSYVDVIKGSPSKSPSHQGDTHTYRAQKHDKV 1528

  Fly  2444 ------DIAART-----------------TTVITS---------------------QS------- 2457
                  :.|.||                 ||..:|                     ||
Zfish  1529 SHLLCLESATRTHLQSVTSEWLSLTLGVSTTYASSCGSPLPPTPPPLPSDLHYTGPQSPTPPVRR 1593

  Fly  2458 ---TTNLRPN---------------------------------LDVLRT---------------- 2470
               |.||.|.                                 :||.::
Zfish  1594 FHPTQNLSPKCSPFFLSQGPITSESLNSPCYSDELLYRDKLTAIDVAQSFSLPMKQIRDHEQEMG 1658

  Fly  2471 --------NINNEFNTLTQNG-------------------------------------------- 2483
                    .:|.:..||.||.
Zfish  1659 HDGKQFIEELNVKEQTLKQNSDPSSLISEPDPYGELMSMFLKNQLYNELEFKLAIRSKNIANQEV 1723

  Fly  2484 --AQP----PNG-----------------------ILKETRTLHKTDALH--------------- 2504
              |:|    |:.                       |..|....|....|.
Zfish  1724 LPAEPLPIKPSSKLEQKLEKQHDNYEKKAEELLSVIWNEKTEFHSPATLQWEDLPELYIQEDDEK 1788

  Fly  2505 ----------------------------------------VDTSSEPLA---------------- 2513
                                                    .:|.|.|||
Zfish  1789 ICTSGLKEEADSSSVTPSFPMSSSPTSDSSLPQSSTGFSSTNTESSPLAVQCTPLSAAKHSPCSP 1853

  Fly  2514 ----------------------------------------------------------------- 2513
                                                                             
Zfish  1854 PIHLASSFELVPYFSSNLATSVISSPSESPPPPLSLYTPLPSPPSSPPYSPIPLPPPPSMALNIP 1918

  Fly  2514 ----------------------------------------------------------------- 2513
                                                                             
Zfish  1919 PPSSSSLPSNPHNTSSPYPPPFSPQAIISSVPPQLFCSPSAPINSTCSSPLQILPSSPFPSLHPP 1983

  Fly  2514 ----------------------------------------------------------------- 2513
                                                                             
Zfish  1984 LYSSCKPLLPTIPASPPSSPSPPPSSSDIAPPSAPKSLPLLSSPPPSSVPVVSSTSTPPSSSPVC 2048

  Fly  2514 ---------------------------YRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTS 2551
                                       ::|:|.|.|:|.|||||.|||||.|:|:||||||||||
Zfish  2049 PLSPRSQPQSPKIKKMMQDSQHAGGDPFQAVYNYVPRNEDELELKEGDVVDVVERCDDGWFVGTS 2113

  Fly  2552 QRTGCFGTFPGNYVE 2566
            :||..|||||||||:
Zfish  2114 RRTRLFGTFPGNYVK 2128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	Sorb	1959..2003	CDD:470634	10/68 (15%)
		SH3_Sorbs_1	2315..2367	CDD:212715	30/51 (59%)
		SH3_Sorbs_2	2384..2436	CDD:212716	33/59 (56%)
		SH3_Sorbs_3	2514..2567	CDD:212714	38/53 (72%)
sorbs2a	XP_073805841.1	None