DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAP and sorbs3

DIOPT Version :9

Sequence 1:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster
Sequence 2:	XP_005162522.1	Gene:	sorbs3 / 541478	ZFINID:	ZDB-GENE-050327-1	Length:	695	Species:	Danio rerio

Alignment Length:	820	Identity:	230/820 - (28%)
Similarity:	315/820 - (38%)	Gaps:	281/820 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1874 PAPGSSTQSSIPSLVQS--------PTPAPPPPIEPLNPS-------------SSTAGGILGTAL 1917
            |..||......|.:.|.        |||...|.:....||             |.|.|...|.|.
Zfish    26 PGSGSRQHFMTPDIPQDVVVISPGLPTPPSSPILNTSAPSQQKVAEVNGGGFPSHTFGSYYGPAE 90

  Fly  1918 LL-GLSLLTAWNKFIYKVKHEYMSEPETGSDRPRKMAQLGRRQ-----YDGIGPVTNDGMPIILR 1976
            .. |||     |..|           ::|||...|.:  |.|:     :.|||||...||||..|
Zfish    91 TFGGLS-----NGGI-----------QSGSDTLPKTS--GTREERLIKFSGIGPVDETGMPIASR 137

  Fly  1977 SEVKEPHQHEWYKRLYQTIHKQKNGDDFVIRYKCPRARPSYKSNGYVSEPEPNYDSDYSTVRYRT 2041
            |.|.:|  .:||:.:::.|||:....:|..|   .|...||.|   :...:..: ||..|:   |
Zfish   138 SSVNKP--KDWYRSMFRQIHKKPEEPEFDWR---ERKLSSYSS---IDSAQDGF-SDTITL---T 190

  Fly  2042 QNPHRVQSVSSAVNVRNLNQDEKLYGTMPNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKEWW 2106
            |:       .:..:..:|...    |..|.|    :|.:..:||| |..|..|:.....:.:
Zfish   191 QH-------GALTDWADLGDS----GKHPEP----KNIFDFEPGR-EAVTGDHNQYLRSKSQ--- 236

  Fly  2107 DEVMDIFNGNLEQSKLSPLYTEGNLSRALAKESGYTSDSNLVFRKKEVPVSSPLSPVEQKQAYKS 2171
               :.:.:.:::....||     ::...|..|          ..:.|..:.|.:..:|:|.:.|.
Zfish   237 ---LPLHHTSVKPQSQSP-----SIEATLVSE----------LNQFEAELDSEIRGLERKLSQKQ 283

  Fly  2172 LQAGGEPPLLGFRKPAPEKPRDLDPNAPPIPPQPPVK-GLSSYDFPYSTDTVDGSDVNIHFKTPI 2235
            .|..|...:.. ..||.........|:.||.|...|| |::|
Zfish   284 YQRPGRGEVKA-NAPATRTGEKRQENSSPIIPCSAVKQGITS----------------------- 324

  Fly  2236 RHEQRQNLSEEELAIRQAEHMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDF 2300
                                                     |..|.|:...|:.         ||
Zfish   325 -----------------------------------------SFMHADDHISSKM---------DF 339

  Fly  2301 PTDVTLKSLVGPK------TVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGL 2359
            |          ||      ..|||.||||.|:.|||:.:|||.:||.||||||||||||:..:|:
Zfish   340 P----------PKKEERKMKAARAKFNFQAQSPKELTIQKGDVVYIHRQIDANWYEGEHHGRVGI 394

  Fly  2360 LPASYVEIVSRDGARTPSKRPS-----EGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFE 2419
            .|.|||||:......||.|.|:     .|:|.|.|.|.|...:|||..|||::::|||||.:|.|
Zfish   395 FPTSYVEIIPPTEKPTPIKSPTIQVLEYGEAAALYTFNADLPVELSFRKGEVISITRRVDDHWLE 459

  Fly  2420 GKIA--NRKGIFPCSYVEV---LTDIGAEDIAARTTTVITSQSTTNLRPN---LDVLRTNINNEF 2476
            |:||  .|.||||.|||:|   .....::|..:..|  :|.:..:..||.   |..|..:...:.
Zfish   460 GRIAGTTRSGIFPISYVQVNKMPRTKSSDDFPSSPT--LTPEPLSPGRPQHSPLSPLSRSPEPQL 522

  Fly  2477 NTLTQNG--------------AQPPNGIL-------------KETRTLH-----KTD-------A 2502
            :...|:.              .||.|..|             |.|..:|     :||       :
Zfish   523 SHHKQSSQSRSPLSHAQATSPKQPTNHFLFSPGPTSSTSPTSKRTGLMHLHNTPETDSRSPVSPS 587

  Fly  2503 LHV-----------------------------------DTSSEPL-------AYRALYKYRPQNS 2525
            .||                                   .||..|.       .|:|:|.|:|||.
Zfish   588 SHVLQSLQGPGLPAKHASPYITQDVARTQSSQPNTVISSTSQSPANMGHLRQPYKAVYNYKPQNR 652

  Fly  2526 DELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYV 2565
            |||||.|||:|.||||||||||||||:||..|||||||||
Zfish   653 DELELREGDIVQVLEKCDDGWFVGTSERTEAFGTFPGNYV 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404	18/48 (38%)
		SH3_Sorbs_1	2315..2367	CDD:212715	33/51 (65%)
		SH3_Sorbs_2	2384..2436	CDD:212716	29/53 (55%)
		SH3_Sorbs_3	2514..2567	CDD:212714	41/52 (79%)
sorbs3	XP_005162522.1	Sorb	117..165	CDD:295396	19/49 (39%)
		SH3_Vinexin_1	349..403	CDD:212854	34/53 (64%)
		SH3_Sorbs_2	424..478	CDD:212716	29/53 (55%)
		NCOA_u2	473..585	CDD:293270	21/113 (19%)
		SH3_Vinexin_3	638..695	CDD:212851	41/55 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7576
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004115
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8484
SonicParanoid	1	1.000	-	-		X3387
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.940