DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAP and l(3)05822

DIOPT Version :9

Sequence 1:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster
Sequence 2:	NP_001262702.1	Gene:	l(3)05822 / 47260	FlyBaseID:	FBgn0010877	Length:	600	Species:	Drosophila melanogaster

Alignment Length:	800	Identity:	154/800 - (19%)
Similarity:	237/800 - (29%)	Gaps:	311/800 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1735 PESDVEAPPVRILEGQ-----AEANLRQLPRHLREFAKFSTSEQLPDGAQMERHEEQERREEATD 1794
            |.....|||..  .||     |.|:|.||...|:                 ::|.:|::
  Fly     4 PSRPAPAPPGS--RGQSAAAGANASLEQLRLQLQ-----------------QQHLQQQQ------ 43

  Fly  1795 NAHSSATKKTSIVKTYKVSRLPPSVQGEFPGQ-----FSGGNRGRLYRERSQTARLVSHNIPLEL 1854
             ......:|.:|       :|||..:|....|     .|..|.|.|:.|            |...
  Fly    44 -GAGGGLQKLTI-------KLPPPPKGPLQSQHKRTTVSNNNNGSLFDE------------PTGG 88

  Fly  1855 TSNHSSSPDSDFNPGCGSSPAPGSSTQSSIPSLVQSPTPAPPPPIEPLN------PSSSTAGGIL 1913
            ||.....|.:.:.|.......|.....:......:.|.|.||||...:|      .:||.|..:.
  Fly    89 TSITRKFPQARYTPATNWDDDPFGGGSNGNDRFKKMPPPRPPPPKVLVNGQNMTKSNSSMASAVT 153

  Fly  1914 GTALLLGLSLLTAWNKFIYKVKHEYMSEPETGSDRPRKMAQLGRRQYD------GIGPVTNDGMP 1972
            |           ...:.:..:.|...|.....:...:..|:  .|.|.      |..|..|....
  Fly   154 G-----------GTGRLMSNIFHRKKSTSTASAAASKAAAE--NRVYGLSSGNAGATPSNNSSSS 205

  Fly  1973 IILRSEVKEPHQHEWYKRLYQTI---------H--KQKNGDDFVIRYKCPRARPSY--------- 2017
            ....:.........|......|.         |  .|:..|..:|.:..|.:.|::
  Fly   206 ASSAAFSNVDWNAAWNTATTTTTTTSSSSHSSHYASQQTADAQLISFDSPPSSPTFTQKSNSDCV 270

  Fly  2018 -------------KSNGYVSEPEPNYDSDYSTVRYRTQNP----HRVQSVS-------------S 2052
                         .:||.||:||..::.||...|..||:|    ..|.||.             .
  Fly   271 SVDSFSSDSNFSSPNNGSVSQPESGFEDDYHRSRPSTQSPLDPWEAVDSVGLGGVDSFGSAPVRQ 335

  Fly  2053 AVNVRNLNQDEKLYG-----------TMPNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKEWW 2106
            ...|::...|..|..           |||..||                    ..:|:|.|
  Fly   336 TYQVQSRGSDNPLCNGKSLLPPTQSLTMPTIIK--------------------PKISQKPK---- 376

  Fly  2107 DEVMDIFNGNLEQSKLSPLYTEGNLSRALAKESGYTSDSNLVFRKKEVPVSSPLSPVEQKQAYKS 2171
                         :...|.:..|:|....:..|||
  Fly   377 -------------APKPPPFIGGHLPPGYSIPSGY------------------------------ 398

  Fly  2172 LQAGGEPPLLGFRKPAPEKPRDLDPNAPPIPPQPPVKGLSSYDFPYSTDTVDGSDVNIHFKTPIR 2236
              ||.|.|      |:|..|:     .||.||.|...|..|.     .|.::|
  Fly   399 --AGSETP------PSPPMPK-----GPPPPPPPASSGGISL-----LDVING------------ 433

  Fly  2237 HEQRQNLSEEELAIRQAEHMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDFP 2301
                   ..:.||:...           .:.|::|                :..|.|:
  Fly   434 -------KVDALALSNG-----------CQGYMEE----------------EVVPYAV------- 457

  Fly  2302 TDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGE-HNAMIGLLPASYV 2365
                            ||::|.|....:||||:|:.||:.......|..|. .:...|:.|.:||
  Fly   458 ----------------ALYDFDGIEPGDLSFREGEKIYLLDHPTPEWLRGRTRSGCEGIFPINYV 506

  Fly  2366 EI------------VSRDGARTPSKRPSEGQ---ARAKYNFQAQSGIELSLNKGELVTLTRRVDG 2415
            :|            .....|..||..||:.|   |...|:|..:...:|:|.:.||||:..|::.
  Fly   507 DIKVPLGATGGAAAAPTASAAAPSPSPSQQQLPTALCLYHFPGEVEGDLALQENELVTVLYRINE 571

  Fly  2416 NWFEGKIANRKGIFPCSYVE 2435
            :|..|::|.|:|.||.::::
  Fly   572 DWLYGEVAGRQGQFPANFLD 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404	8/60 (13%)
		SH3_Sorbs_1	2315..2367	CDD:212715	17/52 (33%)
		SH3_Sorbs_2	2384..2436	CDD:212716	18/54 (33%)
		SH3_Sorbs_3	2514..2567	CDD:212714
l(3)05822	NP_001262702.1	SH3	452..506	CDD:214620	17/76 (22%)
l(3)05822	NP_001262702.1	SH3	540..591	CDD:302595	17/50 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46655
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.000