DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAP and SH3RF3

DIOPT Version :9

Sequence 1:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster
Sequence 2:	NP_001092759.1	Gene:	SH3RF3 / 344558	HGNCID:	24699	Length:	882	Species:	Homo sapiens

Alignment Length:	364	Identity:	105/364 - (28%)
Similarity:	151/364 - (41%)	Gaps:	105/364 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2281 TDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQID 2345
            |....|:.|:|..|                   ...:||::::|:...:|.|.|||.|.:||::|
Human   183 TSRTAPAAKNPCLL-------------------PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVD 228

  Fly  2346 ANWYEGEHNAMIGLLPASYVEIVSRDGARTPSKRPSEGQARAKYNFQAQSGIE----LSLNKGEL 2406
            ..||.||.:...|.|||||::.:.    ..|...|   |.:|.|:|:.:...:    |:..|.|:
Human   229 EQWYHGELHGTQGFLPASYIQCIQ----PLPHAPP---QGKALYDFEMKDKDQDKDCLTFTKDEI 286

  Fly  2407 VTLTRRVDGNWFEGKIANRKGIFPCSYVE-------------------------VLTDIGAEDIA 2446
            :|:.||||.||.||.:.::.||||..|||                         :.:|.||....
Human   287 LTVLRRVDENWAEGMLGDKIGIFPLLYVELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASV 351

  Fly  2447 ARTTTVITSQSTTNLRPNLDVLR-TNINNEFNTL--TQNGAQPPN-------------------- 2488
            |.:.|:.:|.:.:..:..:|..: |...:.|..|  |...:|..:
Human   352 APSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRA 416

  Fly  2489 ----GILKETRTLHKTDALHVDTSSEPLA-----------------------YRALYKYRPQNSD 2526
                |.|........|..:.....|.|.|                       |.|||.|:||.||
Human   417 AARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSD 481

  Fly  2527 ELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYV 2565
            ||||.:|::..|||||.||||.|.|.|||..|.||||||
Human   482 ELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404
		SH3_Sorbs_1	2315..2367	CDD:212715	22/51 (43%)
		SH3_Sorbs_2	2384..2436	CDD:212716	23/80 (29%)
		SH3_Sorbs_3	2514..2567	CDD:212714	35/52 (67%)
SH3RF3	NP_001092759.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..42
		RING	56..98	CDD:238093
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..159
		SH3_SH3RF3_1	197..250	CDD:212861	22/52 (42%)
		SH3_SH3RF3_2	260..314	CDD:212864	20/53 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..399		6/30 (20%)
		Interaction with RAC1. /evidence=ECO:0000269\|PubMed:20696164	369..439		9/69 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..458		3/24 (13%)
		SH3_SH3RF3_3	467..523	CDD:212858	35/54 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..664
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..747
		SH3_SH3RF_C	827..881	CDD:212719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910