Protein Alignment CAP and Sh3d19

DIOPT Version :10

• Sequence 1: NP_001369075.1
• Gene: CAP / 36084
• FlyBaseID: FBgn0033504
• Length: 2568
• Species: Drosophila melanogaster
• Sequence 2: XP_011238437.1
• Gene: Sh3d19 / 27059
• MGIID: 1350923
• Length: 1071
• Species: Mus musculus
• Alignment Length: 1225
• Identity: 259/1225 - (21%)
• Similarity: 420/1225 - (34%)
• Gaps: 379/1225 - (30%)

  Fly  1550 STTSRRGV---SPAPPPVATPQQQQVPPPAYDRQQR-----RSSLPRELHEQQLKYILSKEEELK 1606
            |::||..:   |||.|.:.|..|:......:||.:|     |||....|  ..::.::.:.....
Mouse    13 SSSSRETLSRYSPAQPFLVTDPQKATKVCLFDRNERHKPEHRSSSQGPL--SSIRAVIKRSSRTC 75

  Fly  1607 FEVERLQQERRRLMEEMQRAPVLPAPQRRESYRPAAKLPTLSEDEVFRQQMAEEWM-NKV--AER 1668
            .:.| |.::|||    .:...|...|.|..|:.|.|..|.|.....   ..|..|. |.:  ||.
Mouse    76 IQSE-LHRDRRR----PEITIVAAEPLRPASWFPGAPPPGLGFPST---PGAGPWRPNDLVPAEL 132

  Fly  1669 EERRQHKIIRISKIE----DEHDHSAVDKATISDEFLDRVKERRHKLSMPADSDWESGAESQPQP 1729
            ....:..|..|::::    :.::.:|..::||:.               ...:|:....:|.|.|
Mouse   133 PPSYEQVIKEINQVQVNATNNNNAAATPRSTITS---------------ATQTDFPEDIDSDPPP 182

  Fly  1730 AAQSQPESDVEAPPVRILEGQAEANLRQLPRHLREFAKFSTSEQ--LPDGAQMERHEEQERREEA 1792
            ..|:         |::.|:....|:...||..:.....|...|:  .|:.....|......|.::
Mouse   183 TLQA---------PLKPLQPSPAASAGNLPPGVAPLIVFDICEEQTCPENPSATRCPVPRPRSKS 238

  Fly  1793 TDNAHSSATKKTSIVKTYKVSRLPPSVQGEFPGQFSGGNRGRLYRERSQTARLVSHNIPLELTSN 1857
              |....|....|..|..:.|.:.|  :.::|                      .|.: |:.|.|
Mouse   239 --NLRPVARDANSKEKNSQKSPVTP--REDWP----------------------PHCL-LDSTCN 276

  Fly  1858 HSS-------SPDSDFNPGCGSSPAPGSSTQSSIPSLVQSPTPAP---PP--------PIEPLNP 1904
            ..|       :.:...|.......|....|.:.||.|.:.|...|   ||        |:....|
Mouse   277 LDSQAMMNIMNTEQSQNTIVSRIKAFEGQTNTEIPGLPKKPEIIPRTIPPKPAVSSGKPLVAPKP 341

  Fly  1905 SSSTAGGILGTALLLGLSLLTAWNKFIYKVKHEYMSEPETGSDRPRKMAQLGRRQYDGIGPVTND 1969
            :::.|.|...|           |.:...||...   |..|....|         |..||.|||..
Mouse   342 AANRASGEWDT-----------WAENRLKVTSR---EGLTPYSSP---------QEAGITPVTKP 383

  Fly  1970 GMPIILRSEVKEPHQHEWYKRLYQTIHKQKNG-------DDFVIRYKCPRARPSYKSNGYVSEPE 2027
            .:|       |:|     ...|.::::.:.:|       .|...:...|..||........::..
Mouse   384 ELP-------KKP-----TPGLTRSVNHETSGGRPMAESPDTGKKIPTPAPRPLLPKKSASTDAP 436

  Fly  2028 PNYDSDYSTVRYR-TQNPHRVQSVSSAVNVRNLNQDEKLYGTMPNPIKSAQNSYKNQPGRIENYT 2091
            |     |.::..: ...|.|:...|.|...|:|.:     |...||...|..|  ...|.|:..:
Mouse   437 P-----YPSIPPKLVSAPPRLSVASQAKAFRSLGE-----GLPSNPPVPAPQS--KALGDIDLIS 489

  Fly  2092 TGH----SSVSEKEKKEWWDEVMDIFNGNLEQSKLSPLYTEGNLSRALAKESGYTSDSNLVFR-- 2150
            ...    :|.|..|:....:.|:|.|.        .|..||....||:...   .:....|.|
Mouse   490 FDDDVLPTSGSPAEEPTGSETVLDPFQ--------LPTKTEATKERAVQPA---PTRKPTVIRIP 543

  Fly  2151 ------KKEVPVSSPLSPVEQ---------------------KQAYKSLQAGG---EPPLLGFR- 2184
                  ..|.|.|.|..|.|:                     .:..::.::||   .||.|..|
Mouse   544 AKPGKCLHEEPQSPPPLPAEKPVGNTHSAVSGRPSHSDRTRNPELEQASESGGLVQGPPRLPPRP 608

  Fly  2185 ---------KPAPEKPRDLDPNAPPIPPQPPVKGLSSYDFPYSTDTVDGSDVNI-----HFKTPI 2235
                     :|.|:..    |..|| ||:.|....|:.:.|::..:   ||:::     ||.:.:
Mouse   609 VHGKVIPVWRPPPKGA----PERPP-PPKLPASKSSNKNLPFNRSS---SDMDLQKKQSHFVSGL 665

  Fly  2236 RHEQRQNLSEEELAI-RQAEHMQKLYHEERRRKYLQEL------QDMNSRRHTD----------- 2282
            ...:.|....::..: .:.:....||     |||:..:      :|:.||..|:
Mouse   666 SKAKSQIFKNQDPVLPPRPKPGHPLY-----RKYMLSVPHGIANEDIVSRNPTELSCKRGDVLVI 725

  Fly  2283 ------NFT------------PSQK---SPIALNRYDDFPTDVTLKSLVGPKTV------ARALF 2320
                  |:.            |||.   :|:     |:.|......|....|.|      |.||.
Mouse   726 LKQAENNYLECQRGEGTGRVHPSQMKIVTPL-----DERPRGRPNDSGHSQKPVDSGAPHAVALH 785

  Fly  2321 NFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIV-----SRDGARTP-SKR 2379
            :|..:.:.:||...|:.:|:..:|||.||.|:.....|:.||:||:::     .|.|.|.. |..
Mouse   786 DFPAEQADDLSLTSGEIVYLLEKIDAEWYRGKCRNQTGVFPANYVKVIVDIPEGRSGKRESFSSH 850

  Fly  2380 PSEG-QARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKIANRKGIFPCSYVEVLTD---I 2440
            .::| :..|::.:......|||.::||::.||..|:..|..|:|.:|.||||.::||::.|   .
Mouse   851 CAKGPRCVARFEYIGDQKDELSFSEGEVIILTEYVNEEWGRGEIRDRSGIFPLNFVELVGDHPTS 915

  Fly  2441 GAEDIAARTTTVITSQSTTNLRPNLDVLRTNI----NNEFNTLTQNGAQPPNGILKETRTLHKTD 2501
            ||                       ::|.|.:    .||........:.||....|
Mouse   916 GA-----------------------NILSTKVPPKTKNEDPGSNSQDSSPPGEWCK--------- 948

  Fly  2502 ALHVDT--SSEPLAY-------------------------------------------------- 2514
            |||..|  :||.|.:
Mouse   949 ALHSFTAETSEDLPFKRGDRILILERLDSDWYRGRLHDREGIFPAVFVQPCPAEAKGVASAIPKG 1013

  Fly  2515 ---RALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYVE 2566
               :|||.:..:|.|||....|||:..||..||.|..|  :..|..|.||.|||:
Mouse  1014 RKVKALYDFLGENEDELSFKAGDVITELEPIDDAWMRG--ELMGRAGMFPKNYVQ 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	Sorb	1959..2003	CDD:470634	11/50 (22%)
		SH3_Sorbs_1	2315..2367	CDD:212715	20/57 (35%)
		SH3_Sorbs_2	2384..2436	CDD:212716	18/51 (35%)
		SH3_Sorbs_3	2514..2567	CDD:212714	23/106 (22%)
Sh3d19	XP_011238437.1	PHA03247	<103..624	CDD:223021	119/632 (19%)
		SH3_Eve1_1	700..749	CDD:212748	6/48 (13%)
		SH3	780..831	CDD:473055	18/50 (36%)
		SH3_Eve1_3	856..906	CDD:212750	17/49 (35%)
		SH3	946..995	CDD:473055	8/57 (14%)
		SH3	1015..1064	CDD:473055	20/50 (40%)