Protein Alignment CAP and Sorbs2

DIOPT Version :10

• Sequence 1: NP_001369075.1
• Gene: CAP / 36084
• FlyBaseID: FBgn0033504
• Length: 2568
• Species: Drosophila melanogaster
• Sequence 2: XP_011240500.1
• Gene: Sorbs2 / 234214
• MGIID: 1924574
• Length: 1501
• Species: Mus musculus
• Alignment Length: 1837
• Identity: 407/1837 - (22%)
• Similarity: 616/1837 - (33%)
• Gaps: 625/1837 - (34%)

  Fly   994 QSDPKLLVC----LSPGQRDLVNNQTQPDDLL-DAHQKFVERRGYHELSKAQVLEQDHQQQQSEM 1053
            ||.|.||..    .||.......|...|:.|. ||....:..:|:
Mouse    26 QSSPNLLAAGRESQSPDSAWRSYNDRNPETLNGDATYSSLAAKGF-------------------- 70

  Fly  1054 LKTAAMMRELRKSLSPPAPPVPPPPVPVKSAETAAKATAHENAKRDDASEQKQKI--AACESSSL 1116
                   |.:|.:|.....|...||.|.:.....:::..:..:|.|..:.....|  .:|.....
Mouse    71 -------RSVRPNLQDKRSPTQAPPPPARKESFDSQSLINNQSKGDILNSLVTNIQTPSCTEDFT 128

  Fly  1117 ENKPRRAADLGAQQSAE--------QRQSSSTTTSSHKATTE----------------------- 1150
            ..||..    |...|:|        ..:||:|.:.:.|.|..
Mouse   129 NLKPLH----GTMHSSEDSKQTVVYSEESSTTVSYTQKITNPLPAASSSSPAQLGDINTPFLQED 189

  Fly  1151 -TMSSDTAKFPTLD-SMESELARMFPQHKGDIFEEQRKRFSNIEFP-----------SHQPVSQT 1202
             |..|.|.:..||. :...:|...||             |:..:||           |..|:...
Mouse   190 YTQDSQTRRISTLKLTPNQDLGSSFP-------------FNTPQFPQPTDVPSFLKRSCSPIPNP 241

  Fly  1203 KRYS---NIETSSYESKKRMENGQVVYDVSTSSHEKKEQGDPPKDQPVPPVPPPPIMSATKLNGN 1264
            ..::   :|:....||.|:..      :|...|.|...|.|............|  .|...:|||
Mouse   242 DTHTASLSIQIHDLESHKQFP------EVPPESAEMPLQQDRQTSSDATTCQSP--ASQITINGN 298

  Fly  1265 TFIDGDVAP-----KNSQPSRESGSGSGNGTYEEFRQRAKAAADAFGEQREQQNGLDQDRVFKDF 1324
            :  .|.|:|     :...||..|...|.|.:......|:..:|:.:.:..:..:|
Mouse   299 S--GGAVSPVSYYQRPFSPSAYSLPASLNSSIIMQHGRSLDSAETYSQHAQSLDG---------- 351

  Fly  1325 DRLSQQMHAELQSTREKREK--SASMY------DLSGF--------TRPASGHPRLDELQQRRHA 1373
             .:...:.....|..|||..  .|..|      |.||.        .||...:..:  .:|....
Mouse   352 -TMGSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTM--FKQIHMV 413

  Fly  1374 HMQELEREIERSAKSRQERMSSVPRQMEATP---PRTHEIPIELEPRSRRAESLCNLNEPPPRPH 1435
            |..:.:.::..:..:....:.:.|...::.|   .:|:. |:.........::...:..|.|.||
Mouse   414 HKPDEDTDMYNTPYTYNAGLYNSPYSAQSHPAAKTQTYR-PLSKSHSDNGTDAFKEVPSPVPPPH 477

  Fly  1436 ---------TTVGHYNHPVVQDDWSRYANDLGYSENIARPFAREVEICYQRQNQRTPHCIRAPRL 1491
                     :|:.|        ||.              |..|:|:   .|:.:..|..|
Mouse   478 VPPRPRDQSSTLKH--------DWD--------------PPDRKVD---TRKFRSEPRSI----- 512

  Fly  1492 SASTNDLSSSSQYSYDTFNAYGGRRTHAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSRRG 1556
                        :.|:            |..:...|.:||           .|.|
Mouse   513 ------------FEYE------------PGKSSILQHERP-----------PPLP---------- 532

  Fly  1557 VSPAPPPVATPQQQQVPP----PAYDRQQRRSSLPRELHEQQLKYILSKEEELKFEVERLQQERR 1617
              |.|.||  |::....|    |:.|..:..|..||.
Mouse   533 --PTPTPV--PREPSRKPLSVSPSTDGLRSPSPPPRS---------------------------- 565

  Fly  1618 RLMEEMQRAPVLPAPQRRESYRPAAKLPTLSEDEVFRQQMA------EEWMNKVAEREERRQHKI 1676
                      .:|||      ||:|  |.||.....|...|      |.|....:|.|.......
Mouse   566 ----------CVPAP------RPSA--PDLSPTRTGRINPADIDLENEPWYKFFSELEFGHPPPK 612

  Fly  1677 IRISKIEDEHDHSAVDKATISDEFLDRVKERRHKLSMPADS-----DWESGAESQPQ--PAAQSQ 1734
            ..:..::| |.....::.:|....:||..||      |:.|     |:....:|:|.  |.....
Mouse   613 KALDYVQD-HSSGVSNEVSIYQSSIDRSLER------PSSSASMAGDFRKRRKSEPAVGPLRGLG 670

  Fly  1735 PESDVEAPPVRILEGQAEANLRQLPRHLREFAK--FSTSEQLPDGAQMERHEEQERREEATDNAH 1797
            .:|.....|     |:|:     ||.....|.|  .|:|...|..||                 .
Mouse   671 DQSSSRTSP-----GRAD-----LPGSSSTFTKSFISSSPSSPSRAQ-----------------G 708

  Fly  1798 SSATKKTSIVKTYKVSRLPPS--------------VQGEFPGQFSGGNRGRLYRER----SQTAR 1844
            ...:|....:.:|......||              |.|:.....:..|..::.|:.    |.|..
Mouse   709 GDDSKMCPPLCSYSGLNGTPSGELECCNAYRQHLDVPGDSQRAITFKNGWQMARQNAEIWSSTEE 773

  Fly  1845 LVSHNIPLELTSNHSSSPDSDFNPGCGSSPAPGSSTQSSIPSLVQS------PTPAPPPPIEPL- 1902
            .||..|       .|.|.|...|..|.|.|.|.:.::|....|.:.      |.....|.|:.:
Mouse   774 TVSPKI-------KSRSCDDLLNDDCDSFPDPKTKSESMGSLLCEEDSKESCPMTWASPYIQEVC 831

  Fly  1903 --------NPSSSTAGGILGTALLLGLSLLTAWNKFIYKVKH-----EYMSEPETGSDRPRKMAQ 1954
                    :.|:..|.|.|.                :||..|     :.|:.....|.:.|.:..
Mouse   832 GNSRSRLKHRSAHNAPGFLK----------------MYKKMHRINRKDLMNSEVICSVKSRILQY 880

  Fly  1955 LGRRQYDGI---------GPVTNDGMPIILRSEVKEPHQHEWYKRLYQTIHKQKN-GDDFVIRYK 2009
            ...:|:.|:         ..|..|.:|    :.:.|      :::|.|......| ||:.:....
Mouse   881 EKEQQHRGLLHGWSQSSTEEVPRDVVP----TRISE------FEKLIQKSKSMPNLGDEMLSPIT 935

  Fly  2010 --------CPRARPSYKSNGYVSEPEPNYDSDYSTVRYRTQNPHRVQSVSSAVNVR-NLNQDEKL 2065
                    ||:.|.|.:|   :.|.|       :.||:.:|.....:| ::.|.:. .:..||:
Mouse   936 LEPPQNGLCPKRRFSIES---LLEEE-------TQVRHPSQGQRSCKS-NTLVPIHIEVTSDEQ- 988

  Fly  2066 YGTMPNPIKSAQNSYKNQPGRIENYT-----TGHSSVSEKEKKEWWDEVMDIFNGNLE------- 2118
                  |....:.|..:|.|.:.:::     .|.|..||.:...:.....:.|.|:..
Mouse   989 ------PRTHMEFSDSDQDGVVSDHSDYVHVEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHH 1047

  Fly  2119 ---------QSKLSPLYT------------EGNLSRALAKE--SGYTSDSNLV----FRKKEVPV 2156
                     :.:....||            ..|:.|...:|  .|.:..:.||    ||:|::
Mouse  1048 HHRHLISSCKGRCPASYTRFTTMLKHERAKHENMDRPRRQEMDPGLSKLAFLVSPVPFRRKKI-- 1110

  Fly  2157 SSPLSPVEQKQAYKS------------------------LQAGGEPP------LLGFRKP-APEK 2190
               |:|  |||..|:                        .:.|..|.      |:....| .||:
Mouse  1111 ---LTP--QKQTEKAKCKASVVEALDSALKDICDQIKAEKRRGSLPDNSILHRLISELLPQIPER 1170

  Fly  2191 PRDL-----DPNAPPIPPQPPVKGLS--------------SYDFPYSTDTVDGSDVNIHFKTPIR 2236
            ...|     .|...|..|.|| .|.|              |..|| ..||..    |.|
Mouse  1171 NSSLHALKRSPMHQPFHPLPP-DGASHCPLYQNDCGRMPHSASFP-DVDTTS----NYH------ 1223

  Fly  2237 HEQRQNLSEEELAIRQAEHMQKLYHEERRRKYLQELQDM-NSRRHTDNFTPSQKSPIALNRYDDF 2300
                  ..:...|:...:|       |..|.|...|.|: .|.......||.::
Mouse  1224 ------AQDYGSALSLQDH-------ESPRSYSSTLTDLGRSASRERRGTPEKE----------- 1264

  Fly  2301 PTDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYV 2365
                       .|..|:|:::|:.||||||||:||||:||.|:||.|||||||:..:|:.|.|||
Mouse  1265 -----------VKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYV 1318

  Fly  2366 EIVSRDGARTPSK-----RPSE-GQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKI-- 2422
            |.::......|::     :|.| |:|.|||||.|.:.:||||.||:.:.|.:|||.||:||||
Mouse  1319 EKLTPPEKAQPARPPPPVQPGEIGEAIAKYNFNADTNVELSLRKGDRIILLKRVDQNWYEGKIPG 1383

  Fly  2423 ANRKGIFPCSYVEVL--TDIGAEDIAARTTTVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQ 2485
            .||:||||.|||||:  ...||||.                 |:..:..:..::...||:.|..|
Mouse  1384 TNRQGIFPVSYVEVVKRNAKGAEDY-----------------PDPPLPHSYSSDRIYTLSSNKPQ 1431

  Fly  2486 PPNGILKETRTLHKTDALHVDTSSEPLAYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGT 2550
            .| |...|          ::....||  ::|||.|.|:|.|||||.|.|||.|:|||||||||||
Mouse  1432 RP-GFSHE----------NIQGGGEP--FQALYNYTPRNEDELELRESDVVDVMEKCDDGWFVGT 1483

  Fly  2551 SQRTGCFGTFPGNYVER 2567
            |:||..|||||||||:|
Mouse  1484 SRRTKFFGTFPGNYVKR 1500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	Sorb	1959..2003	CDD:470634	10/53 (19%)
		SH3_Sorbs_1	2315..2367	CDD:212715	32/51 (63%)
		SH3_Sorbs_2	2384..2436	CDD:212716	32/53 (60%)
		SH3_Sorbs_3	2514..2567	CDD:212714	39/52 (75%)
Sorbs2	XP_011240500.1	Sorb	375..419	CDD:460492	8/45 (18%)
		SH3_Sorbs2_1	1267..1321	CDD:212853	33/53 (62%)
		SH3_Sorbs2_2	1342..1398	CDD:212856	34/55 (62%)
		SH3_Sorbs2_3	1441..1501	CDD:212850	42/62 (68%)