Protein Alignment CAP and DNMBP

DIOPT Version :9

• Sequence 1: NP_001369075.1
• Gene: CAP / 36084
• FlyBaseID: FBgn0033504
• Length: 2568
• Species: Drosophila melanogaster
• Sequence 2: NP_056036.1
• Gene: DNMBP / 23268
• HGNCID: 30373
• Length: 1577
• Species: Homo sapiens
• Alignment Length: 1532
• Identity: 283/1532 - (18%)
• Similarity: 499/1532 - (32%)
• Gaps: 491/1532 - (32%)

  Fly   470 LNSDFSSGEFNSLQSPLVCEVDSESEGSVVLGPERSPS-DQQVPSSSRVEQHEQVRQKRAQYRNA 533
            |.|::.: :.||.|       |.::.|    ||.|||. :.::|.::     :.......:..|.
Human   364 LTSEYDT-DRNSYQ-------DEDTAG----GPPRSPGVEWEMPLAT-----DSPTSDPTEVVNG 411

  Fly   534 LESH----FMPQLLNPRYLDSILEENEWRNSTASSGGSDQTGIRTPKLNETFPRSQLDFSRRHKR 594
            :.|.    |.|.|...:|..::             |||                        |..
Human   412 ISSQPQVPFHPNLQKSQYYSTV-------------GGS------------------------HPH 439

  Fly   595 REEAPSPLKLETKLLEESTDLESCTRLQSALSPQSEDAELVYLSSSA-----SSSVSDLMELELE 654
            .|:.|..|.||.:           ||..::|.|:...::|..|....     .||||
Human   440 SEQYPDLLPLEAR-----------TRDYASLPPKRMYSQLKTLQKPVLPLYRGSSVS-------- 485

  Fly   655 QAAALAERALVDLDTDASRLI----ARPDDEMSSTSTTTADRSETEAETETETEREGEQSRESTP 715
                            |||::    :.|.....::.|.....|...:.:|....:.|.|
Human   486 ----------------ASRVVKPRQSSPQLHNLASYTKKHHTSSVYSISERLEMKPGPQ------ 528

  Fly   716 VNANPTLASSQSSLLSAATPTPTPTPTPAD---REQLAK-DTNVSGGSTVSFGAASPLAATREEF 776
                     :|..::.|||.:.....|..|   .:||.: :.:::|..|      .|....|...
Human   529 ---------AQGLVMEAATHSQGDGSTDLDSKLTQQLIEFEKSLAGPGT------EPDKILRHFS 578

  Fly   777 VRNMDKVRELIEMTRREQEQGELPRSPSPPPVPPPPASVPPYSPESSSFHLASLQLKRQESNDSH 841
            :.:.:..::::..:.:...:.|||....... ||||.   |.:|.|:|.||...|
Human   579 IMDFNSEKDIVRGSSKLITEQELPERRKALR-PPPPR---PCTPVSTSPHLLVDQ---------- 629

  Fly   842 CSDSTTHSQCTAINLASPPPPPTAQPPTPPLRQKPAPPPVPQ---PVSP-------PAPPTPQSE 896
                         || .|.||...:|..|    .|.||...|   .|||       |...|.:.|
Human   630 -------------NL-KPAPPLVVRPSRP----APLPPSAQQRTNAVSPKLLSRHRPTCETLEKE 676

  Fly   897 ---------PELSVADSVANANADVDADADTDTEAIKKLRLLCTEQLASMPYGEQVLEELASVAQ 952
                     .:.|....|.....:::.|.|..:.|.::|.|:..|:.......| .||:|.....
Human   677 GPGHMGRSLDQTSPCPLVLVRIEEMERDLDMYSRAQEELNLMLEEKQDESSRAE-TLEDLKFCES 740

  Fly   953 NISDQSQNKMPYPMPQLPHIKELQLNANESKSSSAWLGLPTQSDPKLLVCLSPGQRDLVNNQTQP 1017
            ||  :|.|.      :|..::|:.|.:::|.|..|..|..:..:|:
Human   741 NI--ESLNM------ELQQLREMTLLSSQSSSLVAPSGSVSAENPE------------------- 778

  Fly  1018 DDLLDAHQKFVERRGYHELSKAQVLEQDHQQQQSEMLKTAA-MMRELRKSLSPPAPPVPPPPVP- 1080
                   |:.:|:|       |:|:|        |:|:|.. .:|:|...:.....|:....||
Human   779 -------QRMLEKR-------AKVIE--------ELLQTERDYIRDLEMCIERIMVPMQQAQVPN 821

  Fly  1081 ------VKSAETAAKATAHENAKRDDASEQKQKIAACESSSLENKPRRAADLGAQQSAEQRQSSS 1139
                  ..:.:...|.:             ||.:||.|.|....    ...||.:...|
Human   822 IDFEGLFGNMQMVIKVS-------------KQLLAALEISDAVG----PVFLGHRDELE------ 863

  Fly  1140 TTTSSHKATTETMSSDTAKFPTLDSMESELARMFPQHKGDIFEEQRKRFSN------IEFPSH-- 1196
               .::|...:......|.....:..|.     ..:|..|...:.:..::.      |...|.
Human   864 ---GTYKIYCQNHDEAIALLEIYEKDEK-----IQKHLQDSLADLKSLYNEWGCTNYINLGSFLI 920

  Fly  1197 QPVSQTKRYS-------NIETSSYESKKRMENGQV-VYDVSTSSHEKKEQGD-------PPKDQP 1246
            :||.:..||.       |....|:..|..:.|..: |.:::.:.:|.|.:.|       ..:|..
Human   921 KPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKDLVLKYRKGDEDSL 985

  Fly  1247 VPPVPPPPIMSATKLNGNTFIDGDVAPKNSQPSRESGSGSGNGTYEEFRQRAKAAADAFGEQREQ 1311
            :..:        :|||.::.|     .|:::.|......:|      |..:.|   |...|:.|
Human   986 MEKI--------SKLNIHSII-----KKSNRVSSHLKHLTG------FAPQIK---DEVFEETE- 1027

  Fly  1312 QNGLDQDRVFKDFDRLSQQMHAELQSTRE----KREKSASMYDLSGFTRPASGHPRLDELQQRRH 1372
            :|...|:|:.|.|.|   .:...||..||    |...:.||:|:.    ...||..|::. :|.|
Human  1028 KNFRMQERLIKSFIR---DLSLYLQHIRESACVKVVAAVSMWDVC----MERGHRDLEQF-ERVH 1084

  Fly  1373 AHMQELEREIERSAKSRQERMSSVPRQMEATPPRTHEIPIELEPRSRRAESLCNLNEPPPRPHTT 1437
            .::.:   ::..:.|.|.||:...|                       ...|.::...|
Human  1085 RYISD---QLFTNFKERTERLVISP-----------------------LNQLLSMFTGP------ 1117

  Fly  1438 VGHYNHPVVQDDWSRYANDLGYSENIARPFAREVEICYQRQNQRTPH-CIRAPRLSASTNDLSSS 1501
                 |.:||..:.:..:....:|...:  .::.:...:.|:.|..: .:.|..|    ::|...
Human  1118 -----HKLVQKRFDKLLDFYNCTERAEK--LKDKKTLEELQSARNNYEALNAQLL----DELPKF 1171

  Fly  1502 SQYSYDTFN--AYGGRRTHAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSRRGVSPAPPPV 1564
            .||:...|.  .:|....|...::||.:|.:|                .:|.....|
Human  1172 HQYAQGLFTNCVHGYAEAHCDFVHQALEQLKP----------------LLSLLKVAG-------- 1212

  Fly  1565 ATPQQQQVPPPAYDRQQRRSSLPRELHEQQLKYILSKEEELKFEVERLQQ-----ERRRLMEEMQ 1624
                             |..:|....||:..: :|.:.:...|..|.|..     ||:.:..:..
Human  1213 -----------------REGNLIAIFHEEHSR-VLQQLQVFTFFPESLPATKKPFERKTIDRQSA 1259

  Fly  1625 RAPVLPAPQ---RRESYRPAAKLPTLSEDEVFRQQMAEEWMNKVAERE-ERRQHKIIRISKIEDE 1685
            |.|:|..|.   :.|..| |:.|.....:::|:   ||...|...:.: ...:..::.:.|.:|.
Human  1260 RKPLLGLPSYMLQSEELR-ASLLARYPPEKLFQ---AERNFNAAQDLDVSLLEGDLVGVIKKKDP 1320

  Fly  1686 HD-------HSAVDKATISDEFLDRVKERR----------------HKLSMPADSDWESGAESQP 1727
            ..       .:.|.|..:...||.....||                |..|.|......||:....
Human  1321 MGSQNRWLIDNGVTKGFVYSSFLKPYNPRRSHSDASVGSHSSTESEHGSSSPRFPRQNSGSTLTF 1385

  Fly  1728 QPAA----------QSQPESDVEAPPVRILEGQAEANLRQLPRHLREFAKFSTSEQLPDGAQMER 1782
            .|::          |.||: |...||....:|...|:|..           |.||..|.....:.
Human  1386 NPSSMAVSFTSGSCQKQPQ-DASPPPKECDQGTLSASLNP-----------SNSESSPSRCPSDP 1438

  Fly  1783 HEEQERREEATDNAHSSATKKTSIVKTYKVSRLPPSVQGEFPGQFSGGNRGRLYRERSQTARLVS 1847
            ....:.|...:.:......:.|:..::|:..|.|..|....||:  .|....|.:..::||
Human  1439 DSTSQPRSGDSADVARDVKQPTATPRSYRNFRHPEIVGYSVPGR--NGQSQDLVKGCARTA---- 1497

  Fly  1848 HNIPLELTSNHSSSPDSDFNPGCGSSPAPGSSTQSSI 1884
                 :...:.|:.||        .|.|.|:....::
Human  1498 -----QAPEDRSTEPD--------GSEAEGNQVYFAV 1521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404
		SH3_Sorbs_1	2315..2367	CDD:212715
		SH3_Sorbs_2	2384..2436	CDD:212716
		SH3_Sorbs_3	2514..2567	CDD:212714
DNMBP	NP_056036.1	SH3_DNMBP_N1	6..56	CDD:212728
		SH3_DNMBP_N2	70..123	CDD:212729
		SH3_DNMBP_N3	149..199	CDD:212730
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..244
		SH3_DNMBP_N4	247..296	CDD:212731
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..395		12/42 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	591..624		11/36 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..659		6/23 (26%)
		RhoGEF	788..966	CDD:279015	36/216 (17%)
		BAR_DNMBP	1017..1208	CDD:153273	49/261 (19%)
		SH3_DNMBP_C1	1289..1345	CDD:212732	10/58 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1348..1487		30/152 (20%)
		SH3_DNMBP_C2	1517..1573	CDD:213017	0/5 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910