DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAP and Sorbs1

DIOPT Version :9

Sequence 1:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster
Sequence 2:	XP_011245474.1	Gene:	Sorbs1 / 20411	MGIID:	700014	Length:	2033	Species:	Mus musculus

Alignment Length:	2420	Identity:	479/2420 - (19%)
Similarity:	751/2420 - (31%)	Gaps:	929/2420 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   655 QAAALAERALVDLDT--DASRLIARPDDEMSSTSTTTADRSETEAETETETEREGEQSRESTPVN 717
            :|.:::...::.:.|  ..|.|:..||  |..|...|...:.|   ....:...|..|  |:||:
Mouse    31 RARSISAVKIIPVKTVKSPSGLVLPPD--MDPTKICTGKGTVT---LRASSSYRGTPS--SSPVS 88

  Fly   718 ANPTLASSQSSLLSAATPTPTPTPTPADREQLAKDTNVSGGSTVSFGAASPLAATREEFVR---N 779
            ...:......|.|....|:       ||..:|:...:.:|.:     ..|||||.....|.   :
Mouse    89 PQESPKHESKSGLEPEDPS-------ADEWKLSSSADTNGNA-----QPSPLAAKGYRSVHPSLS 141

  Fly   780 MDKVRELIEMTRREQEQGELPRSPSPPPVPPPPASVPPYSPESSSFHLASLQLKRQESNDSHCSD 844
            .||                 |:..|||.:|.|                       ||...:..|.
Mouse   142 ADK-----------------PQVLSPPCLPFP-----------------------QEDRFAWQSP 166

  Fly   845 STTHSQCTAINLASPPPPPTAQPPTPPLRQKPAPPPVPQPVSPP-----AP-------------- 890
            :...:...::.::||.|   ..||:.|.:|.|:   :|.|.|.|     ||
Mouse   167 TIHRNYKDSLYMSSPKP---YIPPSTPSQQNPS---LPTPTSVPLGARLAPRNASCPRSLLLGSM 225

  Fly   891 --PTPQSEPELSVADSVA---NANADVDADADTDTEAIKKLRLLCTEQLASMPYGEQVLEELASV 950
              ..|....:..||..:.   |.:::...:| |..:.:..|.:.|                   :
Mouse   226 GLEVPSQPQQYYVASRLVYSKNVSSNTRCEA-TGNKQVSSLYVPC-------------------L 270

  Fly   951 AQNISDQSQNKMPYPMPQLPHIKELQLNANESKSSSAWLGLPTQSDPKLLVCLSPGQRDLVNNQT 1015
            :.||...|....|      |..::   :|.::.|.:|....|..       ||.||...:...:.
Mouse   271 SNNICRASSENYP------PVARD---SAPDTPSEAAGTQAPAP-------CLVPGTATVGTGKP 319

  Fly  1016 QPDDLLDAHQKFVERRGYHELSKAQVLEQDHQQQQSEMLKTAAMMRELRKSLSPP--APPVPPPP 1078
            .|....|..:.|.:.|           :.|..:.::..|.|.|...:   ::.||  .|.|...|
Mouse   320 PPAPPPDPPKLFFDNR-----------KDDGNRGENHTLGTWASFPD---AVRPPRLGPQVTSDP 370

  Fly  1079 VPVKSAET--------AAKATAHENAKRDDASEQKQKIAACESSSLENKPRRAADLGAQQSAEQR 1135
            ...|:.||        |..||:..:|..:........:........|...|..|.||.....
Mouse   371 ENQKNKETYLLQPCYPAKGATSSSSAPSEVIVVPLYLVNTDRGQGQEGTARTPASLGPLGCV--- 432

  Fly  1136 QSSSTTTSSHKATTETMSSDTAKFPTLDSMESELARMFPQHKGDIFEEQRKRFSNIEFPSH-QPV 1199
                     |.....|.::....|||||.       ..|.|.      ||:       |.| ||.
Mouse   433 ---------HTVPATTPAASPLTFPTLDD-------FIPPHL------QRR-------PHHSQPA 468

  Fly  1200 SQTKRYSNIETSSYESKKRMENGQVVYDVSTSSHEKKEQGDPPKDQPVPPVPPPPIMSATKLNGN 1264
            |.....|                                   |..|..||.||||::.....:.:
Mouse   469 SACGSLS-----------------------------------PASQTSPPSPPPPLVPPVPEDLH 498

  Fly  1265 TFIDGDVAPKNSQPSRESGSGSGNGTYEEFRQRAKAAADAFGEQREQQNGLDQDRVFKDFDRLSQ 1329
            ..::.|:      |...|.:||                ....|........|.    :||...|:
Mouse   499 RGLEPDL------PGAVSSTGS----------------PLLNEVSSSHIETDS----QDFPPTSR 537

  Fly  1330 QMHAE------------LQSTREKREKSASMYDLSGFTRPASGHPRLDELQQRRHAHMQELEREI 1382
            ...|.            ||..||::::.:|:.|      |||.....::......|.:....|..
Mouse   538 PSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSD------PASERRAGEQDPVPTPAELTSPGRAS 596

  Fly  1383 ERSAKSRQERMSSVPRQMEATPPRTHEIPIELEPRSRRAESLCNLNEPPPRPHTTVGHYNHPVVQ 1447
            ||.||....|:  |....:.:...|.|:.|.|....|..:.           :.|:....|.:.:
Mouse   597 ERRAKDASRRV--VRSTQDLSDVSTDEVGIPLRNTERSKDW-----------YKTMFKQIHKLNR 648

  Fly  1448 DDWS-----RYANDLGYSENIARPFA---REVEICYQRQNQRTPHCIRAPRLSASTNDLSSSSQY 1504
            ||.|     ||:    :|::...|.:   .:.|:.|....:........| |.|.::.|.||.:
Mouse   649 DDDSDVHSPRYS----FSDDTKSPLSVPRSKSEMNYIEGEKVVKRSATLP-LPARSSSLKSSPE- 707

  Fly  1505 SYDTFNAYGGRRTHAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSR--RGVSP-------- 1559
                      |....|  ...:...|.:.....|:.|..|....:.|..:  |.:||
Mouse   708 ----------RNDWEP--PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNE 760

  Fly  1560 ------------APPPVA----TPQQQQVPPPAYDRQQRRSSLPRELHEQQLKYILSKEEELKFE 1608
                        .|||..    ||....:.|    |:.|:::|.::|...|        .||:.:
Mouse   761 PWYKFFSELEFGRPPPKKIWDYTPGDCSILP----REDRKTNLEKDLSFCQ--------AELEAD 813

  Fly  1609 VERLQQ-ERRRLMEEMQRAPVLPAPQ-----------------RRESYRPAAKLPTL-SEDEVFR 1654
            :|:::. .:.......|.:.|.|.|.                 :|||......|.:| :|.::::
Mouse   814 LEKVETVNKSPSANSPQSSAVSPTPDITSEPPGYIYSSNFHAVKRESDGTPGGLASLENERQIYK 878

  Fly  1655 ----------------QQMAEEWMNKVAEREERRQHKIIRISKIEDEHDHS-------------- 1689
                            ::.:.....|| :|:....| :|..|.:.....|:
Mouse   879 SVLEGGDIPLQGLSGLKRPSSSASTKV-DRKGGNAH-MISSSSVHSRTFHTSNALGPGCKHKKPL 941

  Fly  1690 AVDKATISDEFLDRVKERRHKLSMPADSDWESGAESQPQPAAQS------QPESDVEAPPVRILE 1748
            :..||.||:....:.|.|   ||.|:....|..:...|...|||      .........|:|:
Mouse   942 SAAKACISEILPSKFKPR---LSAPSALLQEQKSVLLPSEKAQSCENLCVSLNDSKRGLPLRV-- 1001

  Fly  1749 GQAEANLRQLPRHLREF----------AKFSTSEQLP---------DGAQMERHEEQERREEATD 1794
            |.:..||  |.|..|::          .::.||.:.|         ..:...|...|..|...:.
Mouse  1002 GGSIENL--LMRSRRDYDSKSSSTMSLQEYGTSSRRPCPLSRKAGLHFSMFYRDMHQINRAGLSL 1064

  Fly  1795 NAHSSATKKTSIVKTYKVSRLPPSVQGEFPGQFSGGNRGRLYRERSQTARLVSHNIPLELTS--- 1856
            .:.||::.: .:...::.|||..:             ||.|...:..:..:..|.:...:|:
Mouse  1065 GSISSSSVR-DLASHFERSRLTLA-------------RGELGASQEGSEHIPKHTVSSRITAFEQ 1115

  Fly  1857 ---NHSSSPDSDFNPGCGSSPAP-----GSSTQSSIPSLVQSPTPAPPPPIEPLNPSSSTAGGIL 1913
               ...|.|..||:.....||.|     |.::..|..||::|
Mouse  1116 LIQRSRSMPSLDFSGRLSKSPTPVLSRSGLTSARSAESLLES----------------------- 1157

  Fly  1914 GTALLLGLSLLTAWNKFIYKVKHEYMSEPETGSDRPRKMAQLGRRQYDGIGPVTNDGMPIILRSE 1978
             |.|                              |||:|                |||
Mouse  1158 -TKL------------------------------RPREM----------------DGM------- 1168

  Fly  1979 VKEPHQHEWYKRLYQTIHKQKNGDDFVIRYKCPRARPSYKSNGYVSEPEPNYDSDYSTVRYRTQN 2043
                                                   .|.|..:.|..:..:|:: :.:|:..
Mouse  1169 ---------------------------------------DSGGVYASPTCSNMADHA-LSFRSLV 1193

  Fly  2044 PHRVQSVSS-----AVNVRNLNQD---EKLYGTMPNPIKSAQNSYKNQ-PGRIENYTT--GHSSV 2097
            |....|:.|     ..||.|.:::   ..::|..|   |...|..|.. |.....:||  .|...
Mouse  1194 PSEPLSICSDELDHCSNVSNDSREGSGGSVHGDFP---KHRLNKCKGTCPASYTRFTTIRKHEQQ 1255

  Fly  2098 SEKEKKEWWDEVMDIFNGNLEQSKL-SPLYTEGNLSRALAKESGY--TSDS--NLVFRKKEVP-- 2155
            |.:: .:|..:.....|..|....| |||  ...|.:.|.:....  .|||  :...:|.::|
Mouse  1256 SSRQ-SDWRSDSRGDKNSLLRNIHLMSPL--PFRLKKPLQQHPRQPPPSDSSESPAGQKADLPCH 1317

  Fly  2156 --------VSSPLSP--VEQKQAYKSLQAGGEPPLLGFRKPAPEKPRDLDPNAPPIPPQPPVKGL 2210
                    ...||.|  :..:.....|....||||        ::|..|:.....|....||
Mouse  1318 DPQDQPHSAGKPLVPARLSSRHTMARLSHNLEPPL--------DRPAGLEDCTRAINNGNPV--- 1371

  Fly  2211 SSYDFPYSTDTVDGSDVNIHFKTPIRHEQRQN----------LSEEELAIRQAEHMQKLYHEERR 2265
                 |||...:|.:: |...:....|...::          .|.||...|:.:..:||..::||
Mouse  1372 -----PYSDHGLDRNN-NPQSELAAAHGDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 1430

  Fly  2266 RKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDD-FPTDVTLKSLVG-PKTVARALFNFQGQTSK 2328
            .|..||..|:.:|||| ...|:....|...|:.| ...|.|.|...| ....|||.|:|:.||.|
Mouse  1431 LKREQEEADIAARRHT-GVIPTHHQFITNERFGDLLNIDDTAKRKSGLEMRPARAKFDFKAQTLK 1494

  Fly  2329 ELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVEIVSRDGARTPSK-RPSE----GQARAK 2388
            ||..:|||.:||.||||.|||||||:..:|:.|.:|:|::.......|.| .|.:    |:|.||
Mouse  1495 ELPLQKGDVVYIYRQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPRKLAPVQVLEYGEAIAK 1559

  Fly  2389 YNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKI--ANRKGIFPCSYVEVL-----------TDI 2440
            :||...:.:|:|..|||.:||.|:||.||:||:|  .:|:||||.:||:||           .|:
Mouse  1560 FNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVLKRPLVKTPVDYIDL 1624

  Fly  2441 GAEDIAARTTTV-------------------------------ITSQ------------------ 2456
            ......:|:.||                               |||:
Mouse  1625 PYSSSPSRSATVSPQYTSHSKLIMPAPSSLPHPRRALSPEMHAITSEWISLTVGVPGRRSLAMTP 1689

  Fly  2457 -----------------STTNLRPNL--------------------------------------- 2465
                             .:...||:|
Mouse  1690 PLPPLPEASVYDMDRLALSARARPSLPLSLPYSSWSDHSTLRPVVSPMALPPPHKAYSLAPSVQA 1754

  Fly  2466 ----------------------------------------------------------------- 2465

Mouse  1755 PLHVNGDGGIHIRQDGFSQPPPGNSDRVISELSDAFSSQSKRQPWREDGPYDRKAESEAGERYPG 1819

  Fly  2466 -------------DVLRTNIN----NEFNT---------------------------------LT 2480
                         ||:|...:    :||:|                                 ..
Mouse  1820 GPKISKKSCLKPSDVVRCLSSEQRLSEFHTPEDSQSCKPLGGPFPAWETGPPELHRAVEADRKAA 1884

  Fly  2481 QNGAQPPN-------------------GILKETRTLHKTDALHVDTSSEPL-------------- 2512
            |:|...|:                   .:..|...:.:....:..|.|.||
Mouse  1885 QSGVSQPSHHSLSAGPDLTESEKNYVEAVCNEIINIAEKSVHYCSTVSHPLDFHHKVPPSDNKSS 1949

  Fly  2513 --------------------------AYRALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTS 2551
                                      :|:|||.|.|||.|||||.:||:|.|:||||||||||||
Mouse  1950 LIISQQPQAQQRRVTPDRSQPSLDLCSYQALYSYVPQNDDELELRDGDIVDVMEKCDDGWFVGTS 2014

  Fly  2552 QRTGCFGTFPGNYVE 2566
            :||..|||||||||:
Mouse  2015 RRTRQFGTFPGNYVK 2029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404	3/43 (7%)
		SH3_Sorbs_1	2315..2367	CDD:212715	29/51 (57%)
		SH3_Sorbs_2	2384..2436	CDD:212716	27/53 (51%)
		SH3_Sorbs_3	2514..2567	CDD:212714	40/53 (75%)
Sorbs1	XP_011245474.1	Sorb	608..654	CDD:128735	11/56 (20%)
		SH3_Sorbs1_1	1480..1534	CDD:212852	30/53 (57%)
		SH3_Sorbs1_2	1554..1611	CDD:212855	29/56 (52%)
		SH3_Sorbs1_3	1974..2032	CDD:212849	40/56 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I7826
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	291	1.000	Inparanoid score	I2770
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004115
OrthoInspector	1	1.000	-	-		otm42853
orthoMCL	1	0.900	-	-		OOG6_106599
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3387
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860