Protein Alignment CAP and SH3D19

DIOPT Version :10

• Sequence 1: NP_001369075.1
• Gene: CAP / 36084
• FlyBaseID: FBgn0033504
• Length: 2568
• Species: Drosophila melanogaster
• Sequence 2: NP_001365050.1
• Gene: SH3D19 / 152503
• HGNCID: 30418
• Length: 1070
• Species: Homo sapiens
• Alignment Length: 1354
• Identity: 266/1354 - (19%)
• Similarity: 432/1354 - (31%)
• Gaps: 419/1354 - (30%)

  Fly  1334 ELQSTREKREKSASMYDLSGFT----RPASGHPRLDELQQRRHAHMQELEREIERSAKSRQERMS 1394
            |.:..||:||       |.|..    |..|||...|..::.:..|         ||  |.|..:|
Human    10 EEEELRERRE-------LGGQRRARGRALSGHSAADRNERNKPEH---------RS--SSQGPLS 56

  Fly  1395 SVPRQMEATPPRTHEIPIELEPRSRRAESLCNLNEP-------PPRPHTTVGHYNHPVVQDDWSR 1452
            |: |.:.....|| .|..||....||.|......||       |..|...:|   .|......|.
Human    57 SI-RAVIKRSSRT-SIQSELHRDRRRPEITIVAAEPLRPASWFPGTPPPGLG---FPTSSAAGSW 116

  Fly  1453 YANDL-------GYSENIARPFAREVEICYQRQNQRTP-HCIRAPRLSASTNDLSSSSQYSYDTF 1509
            ..|:|       .|.:.|......:|..........|| |.|    .||:..|.|....
Human   117 RPNELVPAELPPSYEQVIKEINQVQVNTTNNNNAAATPRHTI----TSATQTDFSEEID------ 171

  Fly  1510 NAYGGRRTHAPMLNQAQ-QQQRPHYGSCYSMIERDPNPRYISTTSRRGVSPAPPPVATPQQQQVP 1573
                   ...|...||. :..:|     :|.:.....|..::......:|..|.....|...:.|
Human   172 -------NDLPQTLQAPLKPLQP-----FSAVSSGNLPTNVAPLIVFDISEEPNCPENPSATRCP 224

  Fly  1574 PPAYDRQQRRSSLPRELHEQQLKYILSKEEELKFEVERLQQERRRLMEEMQRAPVLPAPQRRESY 1638
            .|....:.....:||:.|                            ::|..:..:.||....||.
Human   225 VPKPRSKSNLRPIPRDSH----------------------------IKEQSQQKISPAAVGEESS 261

  Fly  1639 --RPAAKLPTLSEDEVFRQQMAEEWMNKVAEREERRQHKII-RISKIEDEHD------------- 1687
              ||.:.|...|..:   .|.....||     .|:.|:.|: ||...|.:.:
Human   262 PGRPQSLLDNASTSD---SQAVMNIMN-----TEQSQNSIVSRIKVFEGQTNIETSGLPKKPEIT 318

  Fly  1688 -HSAVDKATISDEFLDRVKERRHKLSMPADSDWESGAESQPQPAAQSQPESDVEAPPVRILEGQA 1751
             .|...|.|:|.   .:........:..|..:|:||.|::.:..::   |.....||::
Human   319 PRSLPPKPTVSS---GKPSVAPKPAANRASGEWDSGTENRLKVTSK---EGLTPYPPLQ------ 371

  Fly  1752 EANLRQLPRHLREFAKFSTSEQLPDGAQMERHEEQERREEATDNAHSSATKKTSIVKTYKVSRLP 1816
            ||.  .:|         .|..:||                          ||.:       ..|.
Human   372 EAG--SIP---------VTKPELP--------------------------KKPN-------PGLI 392

  Fly  1817 PSVQGEFPGQFSGGNRGRLYRERSQTARLVSHNIPLELTSNHSSSPDSDFNPGCGSSPA------ 1875
            .||..|.||      ||.| .|.|.:.:.|....|..|....|.|.::...|.....|.
Human   393 RSVNPEIPG------RGPL-AESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRL 450

  Fly  1876 PGSSTQSSIPSLVQSPTPAPPPPI---EPL--------------NPSSSTAGGILGTALLLGLSL 1923
            .|:|...:..||.:.|...||.|:   :||              .||.:.|...:|:.::|
Human   451 AGASQAKAYKSLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVL---- 511

  Fly  1924 LTAWNKFIYKVKHEYMSEPETGSDRPRKMAQLGRRQYDGIGPVTNDGMPIILRSEVKEPHQHEWY 1988
                :.|....|.|.:.|........||                    |.::|...|..
Human   512 ----DPFQLPAKTEPIKERAVQPAPTRK--------------------PTVIRIPAKPG------ 546

  Fly  1989 KRLYQTIHKQKNGDDFVIRYKCPRARPSYKSNGYVSEPEPNYDSDYSTVRYRTQNPHRVQSVSSA 2053
                :.:|:..         :.|...|:.|..|          :.:|||..:..|..|.:::.|
Human   547 ----KCLHEDP---------QSPPPLPAEKPIG----------NTFSTVSGKLSNVERTRNLES- 587

  Fly  2054 VNVRNLNQDEKLYGTMPNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKEWWDEVMDIFNGNLE 2118
                                        |.||:...:......:..:.           .||...
Human   588 ----------------------------NHPGQTGGFVRVPPRLPPRP-----------VNGKTI 613

  Fly  2119 QSKLSPLYTEGNLSRALAKESGYTSDSNLVFRKKEVPVSSPLSPVEQKQAYKSLQAGGEPPLLGF 2183
            .::..|  |:....|....:...|..||     |::|.:...|.::.::...:|..       |.
Human   614 PTQQPP--TKVPPERPPPPKLSATRRSN-----KKLPFNRSSSDMDLQKKQSNLAT-------GL 664

  Fly  2184 RKPAPEKPRDLDPNAPPIP-PQPPVKGLSSYDFPYSTDTVDGSDVNIHFKTPIRHEQRQNLSEEE 2247
            .|...:..::.||..||.| |..|:........|:.                |.:|...:.:..|
Human   665 SKAKSQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHG----------------IANEDIVSQNPGE 713

  Fly  2248 LAIRQAEHMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGP 2312
            |:.::.:.:..|...|......|:.:| ..|.|.     ||...|.       |.|..|:|....
Human   714 LSCKRGDVLVMLKQTENNYLECQKGED-TGRVHL-----SQMKIIT-------PLDEHLRSRPND 765

  Fly  2313 KTVAR-----------ALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGEHNAMIGLLPASYVE 2366
            .:.|:           .|.:|..:...:|:...|:.:|:..:||.:||.|.....||:.||:||:
Human   766 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVK 830

  Fly  2367 IV-----SRDGAR--TPSKRPSEGQARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKIAN 2424
            ::     ..:|.|  ..|......:..|::.:..:...|||.::||::.|...|:..|..|::..
Human   831 VIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 895

  Fly  2425 RKGIFPCSYVEVLTDI---GAEDIAARTTTVITSQSTTNLRPNLDVLRTNINNEFNTLTQNGAQP 2486
            |.||||.::||.:.|.   ||..::.:.......:.:.:            |::.|:|.....:.
Human   896 RTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGS------------NSQVNSLPAEWCEA 948

  Fly  2487 PNGILKET------------RTLHKTDA------LHVDTSSEPLAY------------------- 2514
            .:....||            :.|.:.|:      |.......|..:
Human   949 LHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGR 1013

  Fly  2515 --RALYKYRPQNSDELELLEGDVVHVLEKCDDGWFVGTSQRTGCFGTFPGNYVE 2566
              :|||.:|.:|.|||....||::..||..||.|..|  :..|..|.||.||::
Human  1014 KAKALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQ 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAP	NP_001369075.1	Sorb	1959..2003	CDD:470634	4/43 (9%)
		SH3_Sorbs_1	2315..2367	CDD:212715	17/62 (27%)
		SH3_Sorbs_2	2384..2436	CDD:212716	16/51 (31%)
		SH3_Sorbs_3	2514..2567	CDD:212714	22/74 (30%)
SH3D19	NP_001365050.1	PHA03247	<168..649	CDD:223021	118/701 (17%)
		SH3_Eve1_1	699..748	CDD:212748	10/70 (14%)
		SH3_Eve1_2	779..830	CDD:212749	15/50 (30%)
		SH3_Eve1_3	855..905	CDD:212750	15/49 (31%)
		SH3_Eve1_4	945..994	CDD:212751	6/48 (13%)
		SH3_Eve1_5	1014..1063	CDD:212752	20/50 (40%)